(30 nodes) G1 Phase network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000001524	Uncharacterized protein. (75 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (447 aa)
	E2F2	E2F transcription factor 2. (431 aa)
	ENSUAMP00000006884	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
	TFDP1	Transcription factor Dp-1. (477 aa)
	CDKN1B	Cyclin dependent kinase inhibitor 1B. (200 aa)
	SKP1	S-phase kinase associated protein 1; Belongs to the SKP1 family. (150 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	CCNE1	Cyclin E1; Belongs to the cyclin family. (370 aa)
	ENSUAMP00000010431	Uncharacterized protein. (415 aa)
	RB1	RB transcriptional corepressor 1. (870 aa)
	ENSUAMP00000015907	Uncharacterized protein. (738 aa)
	CDK4	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily. (340 aa)
	ENSUAMP00000018470	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
	E2F4	E2F transcription factor 4. (406 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (74 aa)
	RBL1	RB transcriptional corepressor like 1. (1068 aa)
	CDKN2D	Cyclin dependent kinase inhibitor 2D. (166 aa)
	TFDP2	Transcription factor. (360 aa)
	E2F5	E2F transcription factor 5. (350 aa)
	CDKN2C	Cyclin dependent kinase inhibitor 2C. (168 aa)
	SKP2	S-phase kinase associated protein 2. (436 aa)
	ENSUAMP00000027679	Uncharacterized protein. (51 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	ENSUAMP00000029459	DUF3452 domain-containing protein. (385 aa)
	ENSUAMP00000031131	Protein kinase domain-containing protein. (264 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (294 aa)
	E2F1	E2F transcription factor 1. (400 aa)
	E2F3	E2F transcription factor 3. (469 aa)
	CCND3	Cyclin D3; Belongs to the cyclin family. (292 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCNA1	CCND1	ENSUAMP00000002841	ENSUAMP00000032516	Cyclin A1; Belongs to the cyclin family.	Cyclin D1; Belongs to the cyclin family.	0.491
CCNA1	CCNE1	ENSUAMP00000002841	ENSUAMP00000008795	Cyclin A1; Belongs to the cyclin family.	Cyclin E1; Belongs to the cyclin family.	0.953
CCNA1	CDK4	ENSUAMP00000002841	ENSUAMP00000016521	Cyclin A1; Belongs to the cyclin family.	Cyclin dependent kinase 4; Belongs to the protein kinase superfamily.	0.947
CCNA1	CDK6	ENSUAMP00000002841	ENSUAMP00000008521	Cyclin A1; Belongs to the cyclin family.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.947
CCNA1	CDKN1A	ENSUAMP00000002841	ENSUAMP00000028410	Cyclin A1; Belongs to the cyclin family.	Cyclin dependent kinase inhibitor 1A.	0.934
CCNA1	CDKN1B	ENSUAMP00000002841	ENSUAMP00000007606	Cyclin A1; Belongs to the cyclin family.	Cyclin dependent kinase inhibitor 1B.	0.964
CCNA1	CDKN2D	ENSUAMP00000002841	ENSUAMP00000023785	Cyclin A1; Belongs to the cyclin family.	Cyclin dependent kinase inhibitor 2D.	0.462
CCNA1	CKS2	ENSUAMP00000002841	ENSUAMP00000020627	Cyclin A1; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.838
CCNA1	E2F1	ENSUAMP00000002841	ENSUAMP00000034622	Cyclin A1; Belongs to the cyclin family.	E2F transcription factor 1.	0.991
CCNA1	E2F2	ENSUAMP00000002841	ENSUAMP00000004521	Cyclin A1; Belongs to the cyclin family.	E2F transcription factor 2.	0.970
CCNA1	E2F3	ENSUAMP00000002841	ENSUAMP00000034631	Cyclin A1; Belongs to the cyclin family.	E2F transcription factor 3.	0.970
CCNA1	E2F4	ENSUAMP00000002841	ENSUAMP00000020119	Cyclin A1; Belongs to the cyclin family.	E2F transcription factor 4.	0.756
CCNA1	E2F5	ENSUAMP00000002841	ENSUAMP00000024210	Cyclin A1; Belongs to the cyclin family.	E2F transcription factor 5.	0.692
CCNA1	ENSUAMP00000001524	ENSUAMP00000002841	ENSUAMP00000001524	Cyclin A1; Belongs to the cyclin family.	Uncharacterized protein.	0.947
CCNA1	ENSUAMP00000010431	ENSUAMP00000002841	ENSUAMP00000010431	Cyclin A1; Belongs to the cyclin family.	Uncharacterized protein.	0.962
CCNA1	ENSUAMP00000015907	ENSUAMP00000002841	ENSUAMP00000015907	Cyclin A1; Belongs to the cyclin family.	Uncharacterized protein.	0.655
CCNA1	ENSUAMP00000018470	ENSUAMP00000002841	ENSUAMP00000018470	Cyclin A1; Belongs to the cyclin family.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.995
CCNA1	ENSUAMP00000027679	ENSUAMP00000002841	ENSUAMP00000027679	Cyclin A1; Belongs to the cyclin family.	Uncharacterized protein.	0.793
CCNA1	ENSUAMP00000029459	ENSUAMP00000002841	ENSUAMP00000029459	Cyclin A1; Belongs to the cyclin family.	DUF3452 domain-containing protein.	0.655
CCNA1	ENSUAMP00000031131	ENSUAMP00000002841	ENSUAMP00000031131	Cyclin A1; Belongs to the cyclin family.	Protein kinase domain-containing protein.	0.994