(5 nodes) Wee1-like protein kinase, and M-phase inducer phosphatase network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHEK1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
	WEE1	Wee1-like protein kinase. (645 aa)
	CHEK2	Checkpoint kinase 2. (530 aa)
	WEE2	Wee1-like protein kinase. (530 aa)
	CDC25A	Cell division cycle 25A. (498 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC25A	CHEK1	ENSUAMP00000030676	ENSUAMP00000007243	Cell division cycle 25A.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.995
CDC25A	CHEK2	ENSUAMP00000030676	ENSUAMP00000014002	Cell division cycle 25A.	Checkpoint kinase 2.	0.989
CDC25A	WEE1	ENSUAMP00000030676	ENSUAMP00000008468	Cell division cycle 25A.	Wee1-like protein kinase.	0.860
CDC25A	WEE2	ENSUAMP00000030676	ENSUAMP00000017855	Cell division cycle 25A.	Wee1-like protein kinase.	0.780
CHEK1	CDC25A	ENSUAMP00000007243	ENSUAMP00000030676	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	Cell division cycle 25A.	0.995
CHEK1	CHEK2	ENSUAMP00000007243	ENSUAMP00000014002	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	Checkpoint kinase 2.	0.995
CHEK1	WEE1	ENSUAMP00000007243	ENSUAMP00000008468	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	Wee1-like protein kinase.	0.978
CHEK1	WEE2	ENSUAMP00000007243	ENSUAMP00000017855	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	Wee1-like protein kinase.	0.974
CHEK2	CDC25A	ENSUAMP00000014002	ENSUAMP00000030676	Checkpoint kinase 2.	Cell division cycle 25A.	0.989
CHEK2	CHEK1	ENSUAMP00000014002	ENSUAMP00000007243	Checkpoint kinase 2.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.995
CHEK2	WEE1	ENSUAMP00000014002	ENSUAMP00000008468	Checkpoint kinase 2.	Wee1-like protein kinase.	0.833
CHEK2	WEE2	ENSUAMP00000014002	ENSUAMP00000017855	Checkpoint kinase 2.	Wee1-like protein kinase.	0.833
WEE1	CDC25A	ENSUAMP00000008468	ENSUAMP00000030676	Wee1-like protein kinase.	Cell division cycle 25A.	0.860
WEE1	CHEK1	ENSUAMP00000008468	ENSUAMP00000007243	Wee1-like protein kinase.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.978
WEE1	CHEK2	ENSUAMP00000008468	ENSUAMP00000014002	Wee1-like protein kinase.	Checkpoint kinase 2.	0.833
WEE1	WEE2	ENSUAMP00000008468	ENSUAMP00000017855	Wee1-like protein kinase.	Wee1-like protein kinase.	0.945
WEE2	CDC25A	ENSUAMP00000017855	ENSUAMP00000030676	Wee1-like protein kinase.	Cell division cycle 25A.	0.780
WEE2	CHEK1	ENSUAMP00000017855	ENSUAMP00000007243	Wee1-like protein kinase.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.974
WEE2	CHEK2	ENSUAMP00000017855	ENSUAMP00000014002	Wee1-like protein kinase.	Checkpoint kinase 2.	0.833
WEE2	WEE1	ENSUAMP00000017855	ENSUAMP00000008468	Wee1-like protein kinase.	Wee1-like protein kinase.	0.945