STRINGSTRING
ORC1 ORC1 ENSUAMP00000001303 ENSUAMP00000001303 ENSUAMP00000001912 ENSUAMP00000001912 ENSUAMP00000001945 ENSUAMP00000001945 DBF4 DBF4 DDX11 DDX11 POLE2 POLE2 ENSUAMP00000004684 ENSUAMP00000004684 TIPIN TIPIN POLD2 POLD2 CTC1 CTC1 ENSUAMP00000006705 ENSUAMP00000006705 ENSUAMP00000006773 ENSUAMP00000006773 ENSUAMP00000007405 ENSUAMP00000007405 ENSUAMP00000007930 ENSUAMP00000007930 ENSUAMP00000007940 ENSUAMP00000007940 POLK POLK CDC7 CDC7 MCM7 MCM7 GINS2 GINS2 ENSUAMP00000011011 ENSUAMP00000011011 ORC6 ORC6 ENSUAMP00000011715 ENSUAMP00000011715 ENSUAMP00000011742 ENSUAMP00000011742 ENSUAMP00000011763 ENSUAMP00000011763 ENSUAMP00000012460 ENSUAMP00000012460 ENSUAMP00000013559 ENSUAMP00000013559 ORC2 ORC2 ORC4 ORC4 PCNA PCNA CHTF18 CHTF18 ENSUAMP00000016019 ENSUAMP00000016019 ENSUAMP00000017619 ENSUAMP00000017619 MCM10 MCM10 ENSUAMP00000018638 ENSUAMP00000018638 POLD1 POLD1 CDC6 CDC6 POLI POLI ENSUAMP00000019496 ENSUAMP00000019496 MCM5 MCM5 RFC4 RFC4 REV3L REV3L GINS3 GINS3 MCM6 MCM6 ENSUAMP00000022046 ENSUAMP00000022046 GINS4 GINS4 MCM4 MCM4 POLE3 POLE3 FEN1 FEN1 MCM3 MCM3 MAD2L2 MAD2L2 ORC5 ORC5 RFC3 RFC3 WRN WRN MCM2 MCM2 ENSUAMP00000028130 ENSUAMP00000028130 MCMDC2 MCMDC2 ENSUAMP00000031071 ENSUAMP00000031071 POLE4 POLE4 ENSUAMP00000031776 ENSUAMP00000031776 RFC2 RFC2 MCMBP MCMBP ENSUAMP00000033289 ENSUAMP00000033289 ENSUAMP00000033611 ENSUAMP00000033611 ENSUAMP00000033824 ENSUAMP00000033824 ENSUAMP00000033991 ENSUAMP00000033991 TIMELESS TIMELESS RFC5 RFC5 STN1 STN1 DSCC1 DSCC1 ORC3 ORC3 ENSUAMP00000037532 ENSUAMP00000037532
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
ENSUAMP00000001303DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (578 aa)
ENSUAMP00000001912Uncharacterized protein. (168 aa)
ENSUAMP00000001945Uncharacterized protein. (163 aa)
DBF4DBF4 zinc finger. (673 aa)
DDX11DEAD/H-box helicase 11. (871 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (507 aa)
ENSUAMP00000004684Uncharacterized protein. (191 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
POLD2DNA polymerase delta 2, accessory subunit. (469 aa)
CTC1CST telomere replication complex component 1. (1227 aa)
ENSUAMP00000006705Uncharacterized protein. (266 aa)
ENSUAMP00000006773Uncharacterized protein. (114 aa)
ENSUAMP00000007405Uncharacterized protein. (485 aa)
ENSUAMP00000007930Uncharacterized protein. (115 aa)
ENSUAMP00000007940Uncharacterized protein. (557 aa)
POLKDNA polymerase kappa. (542 aa)
CDC7Cell division cycle 7. (575 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
ENSUAMP00000011011Uncharacterized protein. (465 aa)
ORC6Origin recognition complex subunit 6. (203 aa)
ENSUAMP00000011715DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (404 aa)
ENSUAMP00000011742DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (667 aa)
ENSUAMP00000011763DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (295 aa)
ENSUAMP00000012460MCM domain-containing protein; Belongs to the MCM family. (378 aa)
ENSUAMP00000013559Uncharacterized protein. (126 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CHTF18Chromosome transmission fidelity factor 18. (985 aa)
ENSUAMP00000016019Uncharacterized protein. (711 aa)
ENSUAMP00000017619UmuC domain-containing protein. (558 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (885 aa)
ENSUAMP00000018638Uncharacterized protein. (269 aa)
POLD1DNA polymerase. (1109 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
POLIDNA polymerase iota. (718 aa)
ENSUAMP00000019496WD_REPEATS_REGION domain-containing protein. (720 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
RFC4Replication factor C subunit 4. (363 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (2648 aa)
GINS3GINS complex subunit 3. (216 aa)
MCM6Minichromosome maintenance complex component 6; Belongs to the MCM family. (451 aa)
ENSUAMP00000022046RFC1 domain-containing protein. (138 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (233 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (211 aa)
ORC5Origin recognition complex subunit 5. (424 aa)
RFC3Replication factor C subunit 3. (185 aa)
WRNWRN RecQ like helicase. (1363 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
ENSUAMP00000028130DNA primase; Belongs to the eukaryotic-type primase small subunit family. (419 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
ENSUAMP00000031071Replication factor C subunit 1. (1147 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (115 aa)
ENSUAMP00000031776Uncharacterized protein. (122 aa)
RFC2Replication factor C subunit 2. (368 aa)
MCMBPMinichromosome maintenance complex binding protein. (649 aa)
ENSUAMP00000033289HMG box domain-containing protein. (189 aa)
ENSUAMP00000033611UmuC domain-containing protein. (188 aa)
ENSUAMP00000033824CDT1 domain-containing protein. (780 aa)
ENSUAMP00000033991Uncharacterized protein. (114 aa)
TIMELESSTimeless circadian regulator. (1207 aa)
RFC5Replication factor C subunit 5. (255 aa)
STN1STN1 subunit of CST complex. (285 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (392 aa)
ORC3Origin recognition complex subunit 3. (526 aa)
ENSUAMP00000037532Uncharacterized protein. (209 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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