(50 nodes) Mixed, incl. Preribosome, large subunit precursor, and ATP-dependent RNA helicase DEAD-box, conserved site network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPF1	Ribosome production factor 1 homolog. (349 aa)
	ENSUAMP00000003282	Uncharacterized protein. (120 aa)
	ENSUAMP00000003903	Uncharacterized protein. (260 aa)
	RSL1D1	Ribosomal L1 domain containing 1. (491 aa)
	CEBPZ	CCAAT enhancer binding protein zeta. (954 aa)
	PES1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome; Belongs to the pescadillo family. (589 aa)
	ENSUAMP00000008368	Uncharacterized protein. (430 aa)
	RBM28	RNA binding motif protein 28. (755 aa)
	ZNF593	Zinc finger protein 593. (134 aa)
	FTSJ3	FtsJ RNA 2'-O-methyltransferase 3. (683 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
	RRS1	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (365 aa)
	WDR12	Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (423 aa)
	NOC3L	Nucleolar complex protein 3 homolog. (799 aa)
	GNL3L	G protein nucleolar 3 like. (530 aa)
	RSL24D1	Ribosomal L24 domain containing 1. (168 aa)
	PA2G4	Proliferation-associated 2G4. (394 aa)
	NLE1	Notchless homolog 1. (477 aa)
	GNL3	G protein nucleolar 3. (550 aa)
	DDX55	RNA helicase. (600 aa)
	RPF2	Ribosome production factor 2 homolog. (306 aa)
	GNL2	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (731 aa)
	ENSUAMP00000017877	Uncharacterized protein. (329 aa)
	DDX56	DEAD-box helicase 56. (545 aa)
	GTPBP4	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (645 aa)
	ENSUAMP00000018826	Uncharacterized protein. (112 aa)
	GRWD1	Glutamate rich WD repeat containing 1. (504 aa)
	KCTD19	Potassium channel tetramerization domain containing 19. (918 aa)
	ENSUAMP00000020461	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (824 aa)
	DDX18	RNA helicase. (660 aa)
	WDR74	WD repeat domain 74. (382 aa)
	PUM3	Pumilio RNA binding family member 3. (432 aa)
	NIFK	Nucleolar protein interacting with the FHA domain of MKI67. (297 aa)
	BRIX1	Biogenesis of ribosomes BRX1. (339 aa)
	NIP7	Nucleolar pre-rRNA processing protein NIP7. (183 aa)
	PWP1	PWP1 homolog, endonuclein. (500 aa)
	ENSUAMP00000031478	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (221 aa)
	EBNA1BP2	EBNA1 binding protein 2. (385 aa)
	ENSUAMP00000031956	Uncharacterized protein. (109 aa)
	DDX24	DEAD-box helicase 24; Belongs to the DEAD box helicase family. (582 aa)
	DDX31	RNA helicase. (755 aa)
	ENSUAMP00000032602	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (72 aa)
	DDX27	DEAD-box helicase 27; Belongs to the DEAD box helicase family. (738 aa)
	RRP8	Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (457 aa)
	MRTO4	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (250 aa)
	ENSUAMP00000035250	Uncharacterized protein. (157 aa)
	MAK16	Protein MAK16 homolog; Belongs to the MAK16 family. (297 aa)
	NOC2L	NOC2 like nucleolar associated transcriptional repressor. (553 aa)
	NOP53	Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (469 aa)
	DDX54	ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (924 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRIX1	CEBPZ	ENSUAMP00000029158	ENSUAMP00000007529	Biogenesis of ribosomes BRX1.	CCAAT enhancer binding protein zeta.	0.935
BRIX1	DDX18	ENSUAMP00000029158	ENSUAMP00000021143	Biogenesis of ribosomes BRX1.	RNA helicase.	0.990
BRIX1	DDX24	ENSUAMP00000029158	ENSUAMP00000032261	Biogenesis of ribosomes BRX1.	DEAD-box helicase 24; Belongs to the DEAD box helicase family.	0.751
BRIX1	DDX27	ENSUAMP00000029158	ENSUAMP00000033493	Biogenesis of ribosomes BRX1.	DEAD-box helicase 27; Belongs to the DEAD box helicase family.	0.699
BRIX1	DDX31	ENSUAMP00000029158	ENSUAMP00000032478	Biogenesis of ribosomes BRX1.	RNA helicase.	0.557
BRIX1	DDX54	ENSUAMP00000029158	ENSUAMP00000037501	Biogenesis of ribosomes BRX1.	ATP-dependent RNA helicase DDX54; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	0.695
BRIX1	DDX55	ENSUAMP00000029158	ENSUAMP00000015736	Biogenesis of ribosomes BRX1.	RNA helicase.	0.940
BRIX1	DDX56	ENSUAMP00000029158	ENSUAMP00000017881	Biogenesis of ribosomes BRX1.	DEAD-box helicase 56.	0.922
BRIX1	EBNA1BP2	ENSUAMP00000029158	ENSUAMP00000031526	Biogenesis of ribosomes BRX1.	EBNA1 binding protein 2.	0.996
BRIX1	EIF6	ENSUAMP00000029158	ENSUAMP00000009586	Biogenesis of ribosomes BRX1.	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...]	0.930
BRIX1	ENSUAMP00000003282	ENSUAMP00000029158	ENSUAMP00000003282	Biogenesis of ribosomes BRX1.	Uncharacterized protein.	0.751
BRIX1	ENSUAMP00000003903	ENSUAMP00000029158	ENSUAMP00000003903	Biogenesis of ribosomes BRX1.	Uncharacterized protein.	0.942
BRIX1	ENSUAMP00000008368	ENSUAMP00000029158	ENSUAMP00000008368	Biogenesis of ribosomes BRX1.	Uncharacterized protein.	0.971
BRIX1	ENSUAMP00000017877	ENSUAMP00000029158	ENSUAMP00000017877	Biogenesis of ribosomes BRX1.	Uncharacterized protein.	0.975
BRIX1	ENSUAMP00000018826	ENSUAMP00000029158	ENSUAMP00000018826	Biogenesis of ribosomes BRX1.	Uncharacterized protein.	0.974
BRIX1	ENSUAMP00000020461	ENSUAMP00000029158	ENSUAMP00000020461	Biogenesis of ribosomes BRX1.	SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.974
BRIX1	ENSUAMP00000031478	ENSUAMP00000029158	ENSUAMP00000031478	Biogenesis of ribosomes BRX1.	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.	0.750
BRIX1	ENSUAMP00000031956	ENSUAMP00000029158	ENSUAMP00000031956	Biogenesis of ribosomes BRX1.	Uncharacterized protein.	0.942
BRIX1	ENSUAMP00000032602	ENSUAMP00000029158	ENSUAMP00000032602	Biogenesis of ribosomes BRX1.	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family.	0.750
BRIX1	ENSUAMP00000035250	ENSUAMP00000029158	ENSUAMP00000035250	Biogenesis of ribosomes BRX1.	Uncharacterized protein.	0.975