STRINGSTRING
POLE2 POLE2 ENSUAMP00000007405 ENSUAMP00000007405 ENSUAMP00000011715 ENSUAMP00000011715 ENSUAMP00000011742 ENSUAMP00000011742 ENSUAMP00000011763 ENSUAMP00000011763 PCNA PCNA RFC4 RFC4 ENSUAMP00000022046 ENSUAMP00000022046 POLE3 POLE3 FEN1 FEN1 RFC3 RFC3 WRN WRN ENSUAMP00000031071 ENSUAMP00000031071 POLE4 POLE4 ENSUAMP00000031776 ENSUAMP00000031776 RFC2 RFC2 RFC5 RFC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (507 aa)
ENSUAMP00000007405Uncharacterized protein. (485 aa)
ENSUAMP00000011715DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (404 aa)
ENSUAMP00000011742DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (667 aa)
ENSUAMP00000011763DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (295 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RFC4Replication factor C subunit 4. (363 aa)
ENSUAMP00000022046RFC1 domain-containing protein. (138 aa)
POLE3DNA polymerase epsilon 3, accessory subunit. (147 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
RFC3Replication factor C subunit 3. (185 aa)
WRNWRN RecQ like helicase. (1363 aa)
ENSUAMP00000031071Replication factor C subunit 1. (1147 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (115 aa)
ENSUAMP00000031776Uncharacterized protein. (122 aa)
RFC2Replication factor C subunit 2. (368 aa)
RFC5Replication factor C subunit 5. (255 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.