STRINGSTRING
ORC1 ORC1 ENSUAMP00000001912 ENSUAMP00000001912 ENSUAMP00000001945 ENSUAMP00000001945 DBF4 DBF4 TIPIN TIPIN ENSUAMP00000007930 ENSUAMP00000007930 ENSUAMP00000007940 ENSUAMP00000007940 CDC7 CDC7 MCM7 MCM7 GINS2 GINS2 ORC6 ORC6 ENSUAMP00000012460 ENSUAMP00000012460 ORC2 ORC2 ORC4 ORC4 ENSUAMP00000016019 ENSUAMP00000016019 MCM10 MCM10 ENSUAMP00000018638 ENSUAMP00000018638 CDC6 CDC6 ENSUAMP00000019496 ENSUAMP00000019496 MCM5 MCM5 GINS3 GINS3 MCM6 MCM6 GINS4 GINS4 MCM4 MCM4 MCM3 MCM3 ORC5 ORC5 MCM2 MCM2 MCMDC2 MCMDC2 MCMBP MCMBP ENSUAMP00000033289 ENSUAMP00000033289 ENSUAMP00000033824 ENSUAMP00000033824 TIMELESS TIMELESS ORC3 ORC3 ENSUAMP00000037532 ENSUAMP00000037532
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ORC1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (858 aa)
ENSUAMP00000001912Uncharacterized protein. (168 aa)
ENSUAMP00000001945Uncharacterized protein. (163 aa)
DBF4DBF4 zinc finger. (673 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
ENSUAMP00000007930Uncharacterized protein. (115 aa)
ENSUAMP00000007940Uncharacterized protein. (557 aa)
CDC7Cell division cycle 7. (575 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
ORC6Origin recognition complex subunit 6. (203 aa)
ENSUAMP00000012460MCM domain-containing protein; Belongs to the MCM family. (378 aa)
ORC2Origin recognition complex subunit 2. (577 aa)
ORC4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa)
ENSUAMP00000016019Uncharacterized protein. (711 aa)
MCM10Minichromosome maintenance 10 replication initiation factor. (885 aa)
ENSUAMP00000018638Uncharacterized protein. (269 aa)
CDC6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa)
ENSUAMP00000019496WD_REPEATS_REGION domain-containing protein. (720 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
GINS3GINS complex subunit 3. (216 aa)
MCM6Minichromosome maintenance complex component 6; Belongs to the MCM family. (451 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (233 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
ORC5Origin recognition complex subunit 5. (424 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
MCMBPMinichromosome maintenance complex binding protein. (649 aa)
ENSUAMP00000033289HMG box domain-containing protein. (189 aa)
ENSUAMP00000033824CDT1 domain-containing protein. (780 aa)
TIMELESSTimeless circadian regulator. (1207 aa)
ORC3Origin recognition complex subunit 3. (526 aa)
ENSUAMP00000037532Uncharacterized protein. (209 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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