STRINGSTRING
ENSUAMP00000000623 ENSUAMP00000000623 LSM4 LSM4 LSM7 LSM7 ENSUAMP00000000999 ENSUAMP00000000999 ENSUAMP00000001028 ENSUAMP00000001028 EFTUD2 EFTUD2 ENSUAMP00000001138 ENSUAMP00000001138 PRPF6 PRPF6 ENSUAMP00000003208 ENSUAMP00000003208 C19orf54 C19orf54 ENSUAMP00000003273 ENSUAMP00000003273 ENSUAMP00000003643 ENSUAMP00000003643 ENSUAMP00000003688 ENSUAMP00000003688 TXNL4A TXNL4A LSM1 LSM1 ENSUAMP00000005079 ENSUAMP00000005079 PRPF31 PRPF31 ENSUAMP00000005947 ENSUAMP00000005947 SNRPB SNRPB ENSUAMP00000006861 ENSUAMP00000006861 SF3A3 SF3A3 SF3A1 SF3A1 SF3B3 SF3B3 LSM8 LSM8 LSM8-2 LSM8-2 SNRPF SNRPF SNRPD2 SNRPD2 ENSUAMP00000010072 ENSUAMP00000010072 ENSUAMP00000010166 ENSUAMP00000010166 ENSUAMP00000010169 ENSUAMP00000010169 PRPF3 PRPF3 SNRPA1 SNRPA1 LSM5 LSM5 SNRPE SNRPE SNRPD3 SNRPD3 ENSUAMP00000014318 ENSUAMP00000014318 ENSUAMP00000016259 ENSUAMP00000016259 SNRPD1 SNRPD1 SNRPC SNRPC LSM6 LSM6 ENSUAMP00000019788 ENSUAMP00000019788 SNRNP70 SNRNP70 SNRPN SNRPN ENSUAMP00000020708 ENSUAMP00000020708 LSM3 LSM3 ENSUAMP00000022401 ENSUAMP00000022401 SNRNP40 SNRNP40 SNRPB2 SNRPB2 PRPF4 PRPF4 SF3B1 SF3B1 ENSUAMP00000026187 ENSUAMP00000026187 TXNL4B TXNL4B SF3B2 SF3B2 SART1 SART1 ENSUAMP00000028028 ENSUAMP00000028028 SNRPD2-2 SNRPD2-2 SF3B4 SF3B4 PHF5A PHF5A SNRPD2-3 SNRPD2-3 ENSUAMP00000033911 ENSUAMP00000033911 DDX23 DDX23 SF3B5 SF3B5 CD2BP2 CD2BP2 ENSUAMP00000037248 ENSUAMP00000037248
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000000623Uncharacterized protein. (86 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (139 aa)
LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (120 aa)
ENSUAMP00000000999RRM domain-containing protein. (126 aa)
ENSUAMP00000001028SF3A2 domain-containing protein. (192 aa)
EFTUD2Elongation factor Tu GTP binding domain containing 2. (970 aa)
ENSUAMP00000001138Sm domain-containing protein. (85 aa)
PRPF6Pre-mRNA processing factor 6. (758 aa)
ENSUAMP00000003208Uncharacterized protein. (57 aa)
C19orf54Chromosome 19 open reading frame 54. (346 aa)
ENSUAMP00000003273RRM domain-containing protein. (92 aa)
ENSUAMP00000003643Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (72 aa)
ENSUAMP00000003688Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (78 aa)
TXNL4AThioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (188 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
ENSUAMP00000005079Uncharacterized protein. (78 aa)
PRPF31Pre-mRNA processing factor 31. (499 aa)
ENSUAMP00000005947annotation not available (78 aa)
SNRPBSmall nuclear ribonucleoprotein-associated protein. (214 aa)
ENSUAMP00000006861Sm domain-containing protein. (52 aa)
SF3A3Splicing factor 3a subunit 3. (501 aa)
SF3A1Splicing factor 3a subunit 1. (795 aa)
SF3B3Splicing factor 3b subunit 3. (1217 aa)
LSM8U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (92 aa)
LSM8-2U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa)
SNRPFSm domain-containing protein. (86 aa)
SNRPD2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (53 aa)
ENSUAMP00000010072Sm domain-containing protein. (105 aa)
ENSUAMP00000010166SEC63 domain-containing protein. (329 aa)
ENSUAMP00000010169Uncharacterized protein. (1045 aa)
PRPF3Pre-mRNA processing factor 3. (548 aa)
SNRPA1Small nuclear ribonucleoprotein polypeptide A. (257 aa)
LSM5LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated. (77 aa)
SNRPESmall nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (88 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
ENSUAMP00000014318RRM domain-containing protein. (88 aa)
ENSUAMP00000016259Uncharacterized protein. (194 aa)
SNRPD1Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (117 aa)
SNRPCU1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (148 aa)
LSM6LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (122 aa)
ENSUAMP00000019788Uncharacterized protein. (1338 aa)
SNRNP70Small nuclear ribonucleoprotein U1 subunit 70. (438 aa)
SNRPNSmall nuclear ribonucleoprotein polypeptide N. (287 aa)
ENSUAMP00000020708Sm domain-containing protein. (74 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (114 aa)
ENSUAMP00000022401Uncharacterized protein. (471 aa)
SNRNP40Small nuclear ribonucleoprotein U5 subunit 40. (358 aa)
SNRPB2Small nuclear ribonucleoprotein polypeptide B2. (224 aa)
PRPF4Pre-mRNA processing factor 4. (369 aa)
SF3B1Splicing factor 3b subunit 1. (1122 aa)
ENSUAMP00000026187Sm domain-containing protein. (72 aa)
TXNL4BThioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (149 aa)
SF3B2Splicing factor 3b subunit 2. (910 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (765 aa)
ENSUAMP00000028028Sm domain-containing protein. (48 aa)
SNRPD2-2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (123 aa)
SF3B4Splicing factor 3b subunit 4. (424 aa)
PHF5APHD finger protein 5A. (85 aa)
SNRPD2-3Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
ENSUAMP00000033911Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
DDX23DEAD-box helicase 23. (820 aa)
SF3B5Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
CD2BP2CD2 cytoplasmic tail binding protein 2. (363 aa)
ENSUAMP00000037248MPN domain-containing protein. (979 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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