(13 nodes) Mixed, incl. RecQ family helicase-topoisomerase III complex, and Replication factor A protein 3 network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RECQL5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (986 aa)
	RAD52	RAD52 homolog, DNA repair protein. (415 aa)
	FBH1	F-box DNA helicase 1. (1046 aa)
	ENSUAMP00000011985	UBA domain-containing protein. (480 aa)
	TOP3A	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (992 aa)
	TOP3B	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (685 aa)
	RMI2	RecQ mediated genome instability 2. (145 aa)
	B2M	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
	ENSUAMP00000028972	Uncharacterized protein. (262 aa)
	ENSUAMP00000029985	ERCC4 domain-containing protein. (391 aa)
	ENSUAMP00000031944	Uncharacterized protein. (79 aa)
	RMI1	RecQ mediated genome instability 1. (627 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B2M	ENSUAMP00000011985	ENSUAMP00000023655	ENSUAMP00000011985	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	UBA domain-containing protein.	0.517
B2M	ENSUAMP00000028972	ENSUAMP00000023655	ENSUAMP00000028972	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein.	0.991
B2M	ENSUAMP00000029985	ENSUAMP00000023655	ENSUAMP00000029985	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	ERCC4 domain-containing protein.	0.969
B2M	ENSUAMP00000031944	ENSUAMP00000023655	ENSUAMP00000031944	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Uncharacterized protein.	0.991
B2M	RAD52	ENSUAMP00000023655	ENSUAMP00000003831	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	RAD52 homolog, DNA repair protein.	0.972
B2M	RECQL5	ENSUAMP00000023655	ENSUAMP00000003523	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.714
B2M	RMI1	ENSUAMP00000023655	ENSUAMP00000035829	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	RecQ mediated genome instability 1.	0.983
B2M	RMI2	ENSUAMP00000023655	ENSUAMP00000023077	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	RecQ mediated genome instability 2.	0.909
B2M	RPA1	ENSUAMP00000023655	ENSUAMP00000021083	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.998
B2M	TOP3A	ENSUAMP00000023655	ENSUAMP00000013366	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.985
B2M	TOP3B	ENSUAMP00000023655	ENSUAMP00000013492	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.940
ENSUAMP00000011985	B2M	ENSUAMP00000011985	ENSUAMP00000023655	UBA domain-containing protein.	Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.	0.517
ENSUAMP00000011985	ENSUAMP00000028972	ENSUAMP00000011985	ENSUAMP00000028972	UBA domain-containing protein.	Uncharacterized protein.	0.695
ENSUAMP00000011985	ENSUAMP00000029985	ENSUAMP00000011985	ENSUAMP00000029985	UBA domain-containing protein.	ERCC4 domain-containing protein.	0.990
ENSUAMP00000011985	ENSUAMP00000031944	ENSUAMP00000011985	ENSUAMP00000031944	UBA domain-containing protein.	Uncharacterized protein.	0.695
ENSUAMP00000011985	FBH1	ENSUAMP00000011985	ENSUAMP00000008664	UBA domain-containing protein.	F-box DNA helicase 1.	0.444
ENSUAMP00000011985	RAD52	ENSUAMP00000011985	ENSUAMP00000003831	UBA domain-containing protein.	RAD52 homolog, DNA repair protein.	0.647
ENSUAMP00000011985	RECQL5	ENSUAMP00000011985	ENSUAMP00000003523	UBA domain-containing protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.839
ENSUAMP00000011985	RMI2	ENSUAMP00000011985	ENSUAMP00000023077	UBA domain-containing protein.	RecQ mediated genome instability 2.	0.885
ENSUAMP00000011985	RPA1	ENSUAMP00000011985	ENSUAMP00000021083	UBA domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.787