STRINGSTRING
ENSUAMP00000002089 ENSUAMP00000002089 ENSUAMP00000002099 ENSUAMP00000002099 SFR1 SFR1 RAD51AP1 RAD51AP1 ENSUAMP00000003100 ENSUAMP00000003100 RECQL5 RECQL5 RECQL RECQL RAD52 RAD52 RAD51AP2 RAD51AP2 ENSUAMP00000004964 ENSUAMP00000004964 ENSUAMP00000005292 ENSUAMP00000005292 ENSUAMP00000007143 ENSUAMP00000007143 TONSL TONSL ENSUAMP00000007930 ENSUAMP00000007930 ENSUAMP00000007940 ENSUAMP00000007940 DMC1 DMC1 FBH1 FBH1 ENSUAMP00000008823 ENSUAMP00000008823 SAMHD1 SAMHD1 EPC1 EPC1 ENSUAMP00000010535 ENSUAMP00000010535 CDC7 CDC7 MCM7 MCM7 GINS2 GINS2 AP5Z1 AP5Z1 ENSUAMP00000011876 ENSUAMP00000011876 RAD51C RAD51C ENSUAMP00000012460 ENSUAMP00000012460 ENSUAMP00000012508 ENSUAMP00000012508 ENSUAMP00000012580 ENSUAMP00000012580 XRCC1 XRCC1 TOP3A TOP3A ENSUAMP00000013669 ENSUAMP00000013669 ANKLE1 ANKLE1 RAD54L RAD54L XRCC3 XRCC3 ENSUAMP00000015206 ENSUAMP00000015206 HELQ HELQ ENSUAMP00000016504 ENSUAMP00000016504 ENSUAMP00000016897 ENSUAMP00000016897 ENSUAMP00000017193 ENSUAMP00000017193 BRCA2 BRCA2 ENSUAMP00000018410 ENSUAMP00000018410 NIPBL NIPBL HUS1 HUS1 ENSUAMP00000019286 ENSUAMP00000019286 MCM5 MCM5 ENSUAMP00000020471 ENSUAMP00000020471 REV3L REV3L RPA1 RPA1 ENSUAMP00000021101 ENSUAMP00000021101 PALB2 PALB2 MCM6 MCM6 ENSUAMP00000021642 ENSUAMP00000021642 ENSUAMP00000021647 ENSUAMP00000021647 MRE11 MRE11 GINS4 GINS4 ENSUAMP00000022926 ENSUAMP00000022926 MCM4 MCM4 RMI2 RMI2 NBN NBN NSMCE2 NSMCE2 MCM3 MCM3 NSMCE1 NSMCE1 ZSWIM7 ZSWIM7 INTS3 INTS3 RAD51B RAD51B ZFYVE26 ZFYVE26 ENSUAMP00000025732 ENSUAMP00000025732 WDR48 WDR48 ENSUAMP00000026056 ENSUAMP00000026056 ENSUAMP00000026129 ENSUAMP00000026129 MUS81 MUS81 KAT5 KAT5 WRN WRN MCM2 MCM2 ENSUAMP00000028972 ENSUAMP00000028972 ENSUAMP00000029109 ENSUAMP00000029109 ENSUAMP00000029591 ENSUAMP00000029591 NUCKS1 NUCKS1 ENSUAMP00000030053 ENSUAMP00000030053 MCMDC2 MCMDC2 REC8 REC8 POLL POLL PPP4C PPP4C ENSUAMP00000031944 ENSUAMP00000031944 MBTD1 MBTD1 AUNIP AUNIP ENSUAMP00000034422 ENSUAMP00000034422 SFPQ SFPQ AP5S1 AP5S1 XRCC2 XRCC2 SWSAP1 SWSAP1 RMI1 RMI1 ENSUAMP00000037532 ENSUAMP00000037532 ENSUAMP00000037175 ENSUAMP00000037175 RBBP8 RBBP8 NABP2 NABP2 INIP INIP ENSUAMP00000000852 ENSUAMP00000000852 NABP1 NABP1 ENSUAMP00000001912 ENSUAMP00000001912 ENSUAMP00000002092 ENSUAMP00000002092
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000002089XPGI domain-containing protein. (335 aa)
ENSUAMP00000002099AAA_23 domain-containing protein. (1035 aa)
SFR1SWI5 dependent homologous recombination repair protein 1. (198 aa)
RAD51AP1RAD51 associated protein 1. (336 aa)
ENSUAMP00000003100Uncharacterized protein. (106 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (986 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (641 aa)
RAD52RAD52 homolog, DNA repair protein. (415 aa)
RAD51AP2RAD51 associated protein 2. (1154 aa)
ENSUAMP00000004964Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1696 aa)
ENSUAMP00000005292DUF4502 domain-containing protein. (195 aa)
ENSUAMP00000007143Uncharacterized protein. (61 aa)
TONSLTonsoku like, DNA repair protein. (1345 aa)
ENSUAMP00000007930Uncharacterized protein. (115 aa)
ENSUAMP00000007940Uncharacterized protein. (557 aa)
DMC1Meiotic recombination protein; May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks; Belongs to the RecA family. DMC1 subfamily. (328 aa)
FBH1F-box DNA helicase 1. (1046 aa)
ENSUAMP00000008823TAN domain-containing protein. (111 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (597 aa)
EPC1Enhancer of polycomb homolog 1. (751 aa)
ENSUAMP00000010535Uncharacterized protein. (406 aa)
CDC7Cell division cycle 7. (575 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (719 aa)
GINS2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa)
AP5Z1Adaptor related protein complex 5 subunit zeta 1. (808 aa)
ENSUAMP00000011876ERCC4 domain-containing protein. (277 aa)
RAD51CRAD51 paralog C. (362 aa)
ENSUAMP00000012460MCM domain-containing protein; Belongs to the MCM family. (378 aa)
ENSUAMP00000012508SMC_N domain-containing protein. (1106 aa)
ENSUAMP00000012580GIY-YIG domain-containing protein. (212 aa)
XRCC1X-ray repair cross complementing 1. (630 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (992 aa)
ENSUAMP00000013669Uncharacterized protein. (607 aa)
ANKLE1Ankyrin repeat and LEM domain containing 1. (632 aa)
RAD54LRAD54 like. (745 aa)
XRCC3X-ray repair cross complementing 3. (448 aa)
ENSUAMP00000015206Uncharacterized protein. (392 aa)
HELQHelicase, POLQ like. (1096 aa)
ENSUAMP00000016504BRCT domain-containing protein. (101 aa)
ENSUAMP00000016897Uncharacterized protein. (67 aa)
ENSUAMP00000017193Uncharacterized protein. (91 aa)
BRCA2BRCA2 DNA repair associated. (3458 aa)
ENSUAMP00000018410Checkpoint protein; Belongs to the HUS1 family. (281 aa)
NIPBLNipped-B protein. (1833 aa)
HUS1HUS1 checkpoint clamp component. (336 aa)
ENSUAMP00000019286DUF4502 domain-containing protein. (132 aa)
MCM5DNA helicase; Belongs to the MCM family. (734 aa)
ENSUAMP00000020471Uncharacterized protein. (1157 aa)
REV3LREV3 like, DNA directed polymerase zeta catalytic subunit. (2648 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (685 aa)
ENSUAMP00000021101Uncharacterized protein. (350 aa)
PALB2Partner and localizer of BRCA2. (1177 aa)
MCM6Minichromosome maintenance complex component 6; Belongs to the MCM family. (451 aa)
ENSUAMP00000021642Rad21_Rec8 domain-containing protein. (69 aa)
ENSUAMP00000021647Rad21_Rec8_N domain-containing protein. (566 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (233 aa)
ENSUAMP00000022926Uncharacterized protein. (131 aa)
MCM4DNA helicase; Belongs to the MCM family. (863 aa)
RMI2RecQ mediated genome instability 2. (145 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
NSMCE2NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase. (157 aa)
MCM3DNA helicase; Belongs to the MCM family. (808 aa)
NSMCE1NSE1 homolog, SMC5-SMC6 complex component. (283 aa)
ZSWIM7Zinc finger SWIM-type containing 7. (145 aa)
INTS3Integrator complex subunit 3. (1040 aa)
RAD51BRAD51 paralog B. (271 aa)
ZFYVE26Zinc finger FYVE-type containing 26. (2526 aa)
ENSUAMP00000025732MMS22L_N domain-containing protein. (203 aa)
WDR48WD repeat domain 48. (626 aa)
ENSUAMP00000026056MitMem_reg domain-containing protein. (95 aa)
ENSUAMP00000026129Uncharacterized protein. (146 aa)
MUS81MUS81 structure-specific endonuclease subunit. (552 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
WRNWRN RecQ like helicase. (1363 aa)
MCM2DNA helicase; Belongs to the MCM family. (903 aa)
ENSUAMP00000028972Uncharacterized protein. (262 aa)
ENSUAMP00000029109RECA_2 domain-containing protein. (300 aa)
ENSUAMP00000029591Uncharacterized protein. (70 aa)
NUCKS1Nuclear casein kinase and cyclin dependent kinase substrate 1. (243 aa)
ENSUAMP00000030053Uncharacterized protein. (322 aa)
MCMDC2Minichromosome maintenance domain containing 2. (681 aa)
REC8REC8 meiotic recombination protein. (482 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
PPP4CSerine/threonine-protein phosphatase. (311 aa)
ENSUAMP00000031944Uncharacterized protein. (79 aa)
MBTD1Mbt domain containing 1. (609 aa)
AUNIPAurora kinase A and ninein interacting protein. (356 aa)
ENSUAMP00000034422Uncharacterized protein. (251 aa)
SFPQSplicing factor proline and glutamine rich. (406 aa)
AP5S1Adaptor related protein complex 5 subunit sigma 1. (200 aa)
XRCC2X-ray repair cross complementing 2. (281 aa)
SWSAP1SWIM-type zinc finger 7 associated protein 1. (252 aa)
RMI1RecQ mediated genome instability 1. (627 aa)
ENSUAMP00000037532Uncharacterized protein. (209 aa)
ENSUAMP00000037175MPN domain-containing protein. (156 aa)
RBBP8RB binding protein 8, endonuclease. (873 aa)
NABP2Nucleic acid binding protein 2. (211 aa)
INIPINTS3 and NABP interacting protein. (99 aa)
ENSUAMP00000000852Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (440 aa)
NABP1Nucleic acid binding protein 1. (199 aa)
ENSUAMP00000001912Uncharacterized protein. (168 aa)
ENSUAMP00000002092Uncharacterized protein. (63 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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