STRINGSTRING
ENSUAMP00000000094 ENSUAMP00000000094 ENSUAMP00000000387 ENSUAMP00000000387 LSM4 LSM4 LSM7 LSM7 EXOSC8 EXOSC8 ENSUAMP00000001657 ENSUAMP00000001657 PELO PELO ENSUAMP00000003041 ENSUAMP00000003041 SMG9 SMG9 ENSUAMP00000003534 ENSUAMP00000003534 LSM1 LSM1 EXOSC7 EXOSC7 SMG8 SMG8 ENSUAMP00000004964 ENSUAMP00000004964 CNOT6 CNOT6 EXOSC3 EXOSC3 CNOT3 CNOT3 NCBP1 NCBP1 DCPS DCPS XRN1 XRN1 TTC37 TTC37 ENSUAMP00000007828 ENSUAMP00000007828 NCBP2L NCBP2L ENSUAMP00000008247 ENSUAMP00000008247 UPF1 UPF1 CTIF CTIF DCP1A DCP1A ENSUAMP00000008823 ENSUAMP00000008823 PARN PARN ENSUAMP00000010057 ENSUAMP00000010057 ENSUAMP00000010123 ENSUAMP00000010123 CNOT1 CNOT1 EXOSC2 EXOSC2 MAGOH MAGOH PATL1 PATL1 ZFP36 ZFP36 SAMD4B SAMD4B EXOSC5 EXOSC5 ZFP36L1 ZFP36L1 EXOSC9 EXOSC9 MTPAP MTPAP PNRC2 PNRC2 NOCT NOCT CNOT7 CNOT7 SMG5 SMG5 ZC3H12A ZC3H12A EXOSC10 EXOSC10 PYM1 PYM1 SMG1 SMG1 ENSUAMP00000018593 ENSUAMP00000018593 ENSUAMP00000018950 ENSUAMP00000018950 ENSUAMP00000018955 ENSUAMP00000018955 CASC3 CASC3 NBDY NBDY RC3H2 RC3H2 THRAP3 THRAP3 PNLDC1 PNLDC1 ENSUAMP00000020844 ENSUAMP00000020844 ENSUAMP00000021295 ENSUAMP00000021295 CNOT2 CNOT2 SMG7 SMG7 ENSUAMP00000022295 ENSUAMP00000022295 ENSUAMP00000022308 ENSUAMP00000022308 PATL2 PATL2 CNOT8 CNOT8 RC3H1 RC3H1 EXOSC4 EXOSC4 DHX34 DHX34 TENT2 TENT2 DIS3L2 DIS3L2 ENSUAMP00000026673 ENSUAMP00000026673 EDC4 EDC4 SWT1 SWT1 ENSUAMP00000027230 ENSUAMP00000027230 ENSUAMP00000027231 ENSUAMP00000027231 ENSUAMP00000028178 ENSUAMP00000028178 ENSUAMP00000028179 ENSUAMP00000028179 RBM8A RBM8A ENSUAMP00000029070 ENSUAMP00000029070 ENSUAMP00000030296 ENSUAMP00000030296 DDX5 DDX5 UPF2 UPF2 ZFP36L2 ZFP36L2 ENSUAMP00000031719 ENSUAMP00000031719 DXO DXO SKIV2L SKIV2L PABPC1 PABPC1 UPF3B UPF3B XRN2 XRN2 SMG6 SMG6 ENSUAMP00000033087 ENSUAMP00000033087 ENSUAMP00000033090 ENSUAMP00000033090 ENSUAMP00000033259 ENSUAMP00000033259 POLR2G POLR2G MRTO4 MRTO4 ENSUAMP00000035166 ENSUAMP00000035166 PAN2 PAN2 CNOT6L CNOT6L EIF4A3 EIF4A3 SSB SSB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000000094DCP2 domain-containing protein. (74 aa)
ENSUAMP00000000387eRF1_1 domain-containing protein. (91 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (139 aa)
LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (120 aa)
EXOSC8Exosome component 8. (290 aa)
ENSUAMP00000001657Uncharacterized protein. (70 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
ENSUAMP00000003041LSM14 domain-containing protein. (55 aa)
SMG9SMG9 nonsense mediated mRNA decay factor. (520 aa)
ENSUAMP00000003534Uncharacterized protein. (105 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
EXOSC7Exosome component 7. (291 aa)
SMG8SMG8 nonsense mediated mRNA decay factor. (991 aa)
ENSUAMP00000004964Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1696 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (498 aa)
EXOSC3Exosome component 3. (275 aa)
CNOT3CCR4-NOT transcription complex subunit 3. (749 aa)
NCBP1Nuclear cap binding protein subunit 1. (790 aa)
DCPSDecapping enzyme, scavenger. (303 aa)
XRN15'-3' exoribonuclease 1. (1717 aa)
TTC37Tetratricopeptide repeat domain 37. (1470 aa)
ENSUAMP00000007828Uncharacterized protein. (203 aa)
NCBP2LNuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (162 aa)
ENSUAMP00000008247RNase_PH domain-containing protein. (82 aa)
UPF1UPF1 RNA helicase and ATPase. (1119 aa)
CTIFCap binding complex dependent translation initiation factor. (596 aa)
DCP1ADecapping mRNA 1A. (580 aa)
ENSUAMP00000008823TAN domain-containing protein. (111 aa)
PARNPoly(A)-specific ribonuclease. (459 aa)
ENSUAMP00000010057Uncharacterized protein. (89 aa)
ENSUAMP00000010123Endo/exonuclease/phosphatase domain-containing protein. (440 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2376 aa)
EXOSC2Exosome component 2. (281 aa)
MAGOHMago homolog, exon junction complex subunit. (146 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (430 aa)
ZFP36ZFP36 ring finger protein. (325 aa)
SAMD4BSterile alpha motif domain containing 4B. (695 aa)
EXOSC5Exosome component 5. (197 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
EXOSC9Exosome component 9. (356 aa)
MTPAPMitochondrial poly(A) polymerase. (584 aa)
PNRC2Proline rich nuclear receptor coactivator 2. (139 aa)
NOCTNocturnin. (432 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
SMG5SMG5 nonsense mediated mRNA decay factor. (1011 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (598 aa)
EXOSC10Exosome component 10. (867 aa)
PYM1PYM homolog 1, exon junction complex associated factor. (203 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3522 aa)
ENSUAMP00000018593eIF3_N domain-containing protein; Belongs to the eIF-3 subunit E family. (75 aa)
ENSUAMP00000018950Smg4_UPF3 domain-containing protein. (105 aa)
ENSUAMP00000018955Uncharacterized protein. (268 aa)
CASC3CASC3 exon junction complex subunit. (704 aa)
NBDYNegative regulator of P-body association. (68 aa)
RC3H2Ring finger and CCCH-type domains 2. (1189 aa)
THRAP3Thyroid hormone receptor associated protein 3. (958 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (529 aa)
ENSUAMP00000020844Uncharacterized protein. (68 aa)
ENSUAMP00000021295Uncharacterized protein. (103 aa)
CNOT2CCR4-NOT transcription complex subunit 2. (520 aa)
SMG7SMG7 nonsense mediated mRNA decay factor. (1048 aa)
ENSUAMP00000022295Uncharacterized protein. (119 aa)
ENSUAMP00000022308Uncharacterized protein. (413 aa)
PATL2PAT1 homolog 2. (547 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (292 aa)
RC3H1Ring finger and CCCH-type domains 1. (1125 aa)
EXOSC4Exosome component 4. (245 aa)
DHX34DExH-box helicase 34. (1138 aa)
TENT2Terminal nucleotidyltransferase 2. (484 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (877 aa)
ENSUAMP00000026673Endo/exonuclease/phosphatase domain-containing protein. (609 aa)
EDC4Enhancer of mRNA decapping 4. (1469 aa)
SWT1SWT1 RNA endoribonuclease homolog. (897 aa)
ENSUAMP00000027230Uncharacterized protein. (325 aa)
ENSUAMP00000027231Uncharacterized protein. (113 aa)
ENSUAMP00000028178Uncharacterized protein. (311 aa)
ENSUAMP00000028179CSD domain-containing protein. (89 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa)
ENSUAMP00000029070Uncharacterized protein. (211 aa)
ENSUAMP00000030296Pan3_PK domain-containing protein. (397 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
UPF2UPF2 regulator of nonsense mediated mRNA decay. (1205 aa)
ZFP36L2ZFP36 ring finger protein like 2. (496 aa)
ENSUAMP00000031719Uncharacterized protein. (627 aa)
DXODecapping exoribonuclease. (385 aa)
SKIV2LSki2 like RNA helicase. (1246 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
UPF3BUPF3B regulator of nonsense mediated mRNA decay. (467 aa)
XRN25'-3' exoribonuclease; Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. (952 aa)
SMG6SMG6 nonsense mediated mRNA decay factor. (1414 aa)
ENSUAMP00000033087AAA_12 domain-containing protein. (213 aa)
ENSUAMP00000033090Uncharacterized protein. (2587 aa)
ENSUAMP00000033259Uncharacterized protein. (327 aa)
POLR2GRNA polymerase II subunit G. (241 aa)
MRTO4Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (250 aa)
ENSUAMP00000035166Uncharacterized protein. (508 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1203 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (550 aa)
EIF4A3Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (411 aa)
SSBSmall RNA binding exonuclease protection factor La. (380 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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