STRINGSTRING
CCNT2 CCNT2 MED6 MED6 ENSUAMP00000000316 ENSUAMP00000000316 ENSUAMP00000000397 ENSUAMP00000000397 ENSUAMP00000003531 ENSUAMP00000003531 ENSUAMP00000004460 ENSUAMP00000004460 MED25 MED25 PER1 PER1 ESR1 ESR1 ENSUAMP00000007257 ENSUAMP00000007257 VGLL4 VGLL4 ENSUAMP00000007908 ENSUAMP00000007908 THAP7 THAP7 TEAD2 TEAD2 EPAS1 EPAS1 ZNF644 ZNF644 ENSUAMP00000011014 ENSUAMP00000011014 GATA1 GATA1 ENSUAMP00000011802 ENSUAMP00000011802 ENSUAMP00000011833 ENSUAMP00000011833 ENSUAMP00000011840 ENSUAMP00000011840 ENSUAMP00000012266 ENSUAMP00000012266 ZBTB16 ZBTB16 AR AR HDAC6 HDAC6 ENSUAMP00000013565 ENSUAMP00000013565 SP1 SP1 ENSUAMP00000014408 ENSUAMP00000014408 BCL6 BCL6 ZNF618 ZNF618 PER2 PER2 ENSUAMP00000015886 ENSUAMP00000015886 ENSUAMP00000015887 ENSUAMP00000015887 ENSUAMP00000016793 ENSUAMP00000016793 HDGF HDGF PPARD PPARD SUZ12 SUZ12 SMAD4 SMAD4 ETS1 ETS1 NR1D1 NR1D1 HMGA1 HMGA1 ENSUAMP00000020051 ENSUAMP00000020051 ENSUAMP00000020121 ENSUAMP00000020121 ENSUAMP00000020133 ENSUAMP00000020133 ENSUAMP00000021070 ENSUAMP00000021070 CNOT2 CNOT2 ZBTB8A ZBTB8A ENSUAMP00000023419 ENSUAMP00000023419 ENSUAMP00000023422 ENSUAMP00000023422 RORA RORA HAND1 HAND1 ENSUAMP00000025690 ENSUAMP00000025690 SMAD3 SMAD3 RXRA RXRA RELA RELA ENSUAMP00000027415 ENSUAMP00000027415 ENSUAMP00000027422 ENSUAMP00000027422 CTBP1 CTBP1 THRB THRB EZH2 EZH2 GATA3 GATA3 ZBTB7A ZBTB7A MTF2 MTF2 SMARCD3 SMARCD3 ENSUAMP00000029725 ENSUAMP00000029725 CDK9 CDK9 CREBBP CREBBP CHD6 CHD6 EP300 EP300 EHMT2 EHMT2 NR5A1 NR5A1 NEK6 NEK6 MED1 MED1 EED EED HIF1A HIF1A CREB3 CREB3 PHF1 PHF1 ENSUAMP00000035777 ENSUAMP00000035777 NR1H4 NR1H4 HDAC3 HDAC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCNT2Cyclin T2; Belongs to the cyclin family. (733 aa)
MED6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (257 aa)
ENSUAMP00000000316Homeobox domain-containing protein. (280 aa)
ENSUAMP00000000397Paired domain-containing protein. (216 aa)
ENSUAMP00000003531BTB domain-containing protein. (67 aa)
ENSUAMP00000004460Runt domain-containing protein. (278 aa)
MED25Mediator complex subunit 25. (795 aa)
PER1Period circadian regulator 1. (1293 aa)
ESR1Estrogen receptor 1. (490 aa)
ENSUAMP00000007257Hist_deacetyl domain-containing protein. (252 aa)
VGLL4Vestigial like family member 4. (291 aa)
ENSUAMP00000007908Uncharacterized protein. (851 aa)
THAP7THAP domain containing 7. (313 aa)
TEAD2TEA domain transcription factor 2. (447 aa)
EPAS1Endothelial PAS domain protein 1. (863 aa)
ZNF644Zinc finger protein 644. (1327 aa)
ENSUAMP00000011014Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (474 aa)
GATA1GATA binding protein 1. (413 aa)
ENSUAMP00000011802Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1116 aa)
ENSUAMP00000011833C2H2-type domain-containing protein. (81 aa)
ENSUAMP00000011840BTB domain-containing protein. (208 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
ZBTB16Zinc finger and BTB domain containing 16. (423 aa)
ARAndrogen receptor. (905 aa)
HDAC6Histone deacetylase 6. (1136 aa)
ENSUAMP00000013565Uncharacterized protein. (86 aa)
SP1Sp1 transcription factor. (780 aa)
ENSUAMP00000014408RunxI domain-containing protein. (143 aa)
BCL6BCL6 transcription repressor. (706 aa)
ZNF618Zinc finger protein 618. (944 aa)
PER2Period circadian regulator 2. (1267 aa)
ENSUAMP00000015886C2H2-type domain-containing protein. (363 aa)
ENSUAMP00000015887Uncharacterized protein. (247 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
HDGFHeparin binding growth factor. (239 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
SUZ12SUZ12 polycomb repressive complex 2 subunit. (900 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ETS1ETS proto-oncogene 1, transcription factor. (531 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (600 aa)
HMGA1High mobility group AT-hook 1. (107 aa)
ENSUAMP00000020051Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (445 aa)
ENSUAMP00000020121PHD-type domain-containing protein. (129 aa)
ENSUAMP00000020133Uncharacterized protein. (293 aa)
ENSUAMP00000021070Uncharacterized protein. (833 aa)
CNOT2CCR4-NOT transcription complex subunit 2. (520 aa)
ZBTB8AZinc finger and BTB domain containing 8A. (441 aa)
ENSUAMP00000023419SET domain-containing protein. (162 aa)
ENSUAMP00000023422ANK_REP_REGION domain-containing protein. (975 aa)
RORARAR related orphan receptor A. (522 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
ENSUAMP00000025690Runt domain-containing protein. (196 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
RXRARetinoid X receptor alpha. (469 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
ENSUAMP00000027415Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (145 aa)
ENSUAMP00000027422Uncharacterized protein. (536 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (421 aa)
THRBThyroid hormone receptor beta. (467 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
GATA3GATA binding protein 3. (444 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (529 aa)
MTF2Metal response element binding transcription factor 2. (597 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
ENSUAMP00000029725Uncharacterized protein. (1947 aa)
CDK9Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
CREBBPCREB binding protein. (2333 aa)
CHD6Chromodomain helicase DNA binding protein 6. (2724 aa)
EP300E1A binding protein p300. (2399 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1294 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
NEK6NIMA related kinase 6; Belongs to the protein kinase superfamily. (291 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
EEDEmbryonic ectoderm development. (441 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
PHF1PHD finger protein 1. (567 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (482 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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