30 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AR	Androgen receptor. (905 aa)
	CCNT2	Cyclin T2; Belongs to the cyclin family. (733 aa)
	MED6	Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (257 aa)
	ENSUAMP00000003531	BTB domain-containing protein. (67 aa)
	MED25	Mediator complex subunit 25. (795 aa)
	ESR1	Estrogen receptor 1. (490 aa)
	VGLL4	Vestigial like family member 4. (291 aa)
	ENSUAMP00000007908	Uncharacterized protein. (851 aa)
	TEAD2	TEA domain transcription factor 2. (447 aa)
	EPAS1	Endothelial PAS domain protein 1. (863 aa)
	ENSUAMP00000011014	Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (474 aa)
	GATA1	GATA binding protein 1. (413 aa)
	ENSUAMP00000011833	C2H2-type domain-containing protein. (81 aa)
	ENSUAMP00000011840	BTB domain-containing protein. (208 aa)
	ENSUAMP00000015886	C2H2-type domain-containing protein. (363 aa)
	ENSUAMP00000015887	Uncharacterized protein. (247 aa)
	PPARD	Peroxisome proliferator activated receptor delta. (441 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	ENSUAMP00000021070	Uncharacterized protein. (833 aa)
	ZBTB8A	Zinc finger and BTB domain containing 8A. (441 aa)
	RORA	RAR related orphan receptor A. (522 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (508 aa)
	THRB	Thyroid hormone receptor beta. (467 aa)
	GATA3	GATA binding protein 3. (444 aa)
	CDK9	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
	CREBBP	CREB binding protein. (2333 aa)
	EP300	E1A binding protein p300. (2399 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (823 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	CREBBP	ENSUAMP00000013075	ENSUAMP00000030777	Androgen receptor.	CREB binding protein.	0.735
AR	EP300	ENSUAMP00000013075	ENSUAMP00000031856	Androgen receptor.	E1A binding protein p300.	0.778
AR	ESR1	ENSUAMP00000013075	ENSUAMP00000006270	Androgen receptor.	Estrogen receptor 1.	0.587
AR	HIF1A	ENSUAMP00000013075	ENSUAMP00000034536	Androgen receptor.	Hypoxia inducible factor 1 subunit alpha.	0.522
AR	MED1	ENSUAMP00000013075	ENSUAMP00000034047	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.613
AR	RELA	ENSUAMP00000013075	ENSUAMP00000026886	Androgen receptor.	RELA proto-oncogene, NF-kB subunit.	0.479
AR	SMAD3	ENSUAMP00000013075	ENSUAMP00000026563	Androgen receptor.	Mothers against decapentaplegic homolog.	0.598
AR	SMAD4	ENSUAMP00000013075	ENSUAMP00000018392	Androgen receptor.	Mothers against decapentaplegic homolog.	0.493
CCNT2	CDK9	ENSUAMP00000000217	ENSUAMP00000029754	Cyclin T2; Belongs to the cyclin family.	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	0.999
CCNT2	ESR1	ENSUAMP00000000217	ENSUAMP00000006270	Cyclin T2; Belongs to the cyclin family.	Estrogen receptor 1.	0.435
CCNT2	SMAD4	ENSUAMP00000000217	ENSUAMP00000018392	Cyclin T2; Belongs to the cyclin family.	Mothers against decapentaplegic homolog.	0.484
CDK9	CCNT2	ENSUAMP00000029754	ENSUAMP00000000217	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	Cyclin T2; Belongs to the cyclin family.	0.999
CDK9	ESR1	ENSUAMP00000029754	ENSUAMP00000006270	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	Estrogen receptor 1.	0.651
CDK9	MED1	ENSUAMP00000029754	ENSUAMP00000034047	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.923
CDK9	RELA	ENSUAMP00000029754	ENSUAMP00000026886	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	RELA proto-oncogene, NF-kB subunit.	0.503
CDK9	SMAD4	ENSUAMP00000029754	ENSUAMP00000018392	Cyclin dependent kinase 9; Belongs to the protein kinase superfamily.	Mothers against decapentaplegic homolog.	0.601
CREBBP	AR	ENSUAMP00000030777	ENSUAMP00000013075	CREB binding protein.	Androgen receptor.	0.735
CREBBP	ENSUAMP00000011014	ENSUAMP00000030777	ENSUAMP00000011014	CREB binding protein.	Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters.	0.734
CREBBP	EP300	ENSUAMP00000030777	ENSUAMP00000031856	CREB binding protein.	E1A binding protein p300.	0.997
CREBBP	EPAS1	ENSUAMP00000030777	ENSUAMP00000010476	CREB binding protein.	Endothelial PAS domain protein 1.	0.986