STRINGSTRING
ENSUAMP00000004728 ENSUAMP00000004728 MECP2 MECP2 SCAP SCAP ENSUAMP00000025740 ENSUAMP00000025740 WDR83 WDR83 RORA RORA ENSUAMP00000024458 ENSUAMP00000024458 NDRG1 NDRG1 NF1 NF1 PIN1 PIN1 CRYAB CRYAB HIF1AN HIF1AN CITED2 CITED2 UCP2 UCP2 ADA ADA PTGIS PTGIS SMAD3 SMAD3 PLOD2 PLOD2 EGLN3 EGLN3 ANGPT4 ANGPT4 EDN1 EDN1 ENSUAMP00000030519 ENSUAMP00000030519 ENSUAMP00000030549 ENSUAMP00000030549 VEGFD VEGFD ASCL2 ASCL2 ENSUAMP00000021600 ENSUAMP00000021600 BMP2 BMP2 P4HB P4HB EGR1 EGR1 NARF NARF MYOCD MYOCD ATF2 ATF2 AJUBA AJUBA ENSUAMP00000000439 ENSUAMP00000000439 TP53 TP53 ADO ADO ENSUAMP00000001189 ENSUAMP00000001189 LIMD1 LIMD1 ENSUAMP00000002924 ENSUAMP00000002924 ENSUAMP00000002943 ENSUAMP00000002943 SUV39H2 SUV39H2 ENSUAMP00000021701 ENSUAMP00000021701 ENSUAMP00000003645 ENSUAMP00000003645 HP1BP3 HP1BP3 EPAS1 EPAS1 BACH1 BACH1 SFRP1 SFRP1 NR4A2 NR4A2 STOX1 STOX1 PINK1 PINK1 P2RX3 P2RX3 VEGFC VEGFC MGARP MGARP SIRT2 SIRT2 ZFP36L1 ZFP36L1 ALKBH5 ALKBH5 SOD3 SOD3 PLOD1 PLOD1 ARNT ARNT ENSUAMP00000012276 ENSUAMP00000012276 OPRD1 OPRD1 ENSUAMP00000011731 ENSUAMP00000011731 BNIP3 BNIP3 ENSUAMP00000011462 ENSUAMP00000011462 DDIT4 DDIT4 SIRT1 SIRT1 CAV1 CAV1 ENSUAMP00000008835 ENSUAMP00000008835 LOXL2 LOXL2 ENSUAMP00000009578 ENSUAMP00000009578 ENSUAMP00000009775 ENSUAMP00000009775 ENSUAMP00000021352 ENSUAMP00000021352 TBL2 TBL2 ENSUAMP00000035193 ENSUAMP00000035193 ENSUAMP00000035681 ENSUAMP00000035681 PMAIP1 PMAIP1 PLEKHN1 PLEKHN1 HYOU1 HYOU1 ENSUAMP00000037224 ENSUAMP00000037224 NOP53 NOP53 TGFB2 TGFB2 AGER AGER VEGFA VEGFA NOL3 NOL3 SRF SRF HMOX1 HMOX1 MTOR MTOR VEGFB VEGFB PDK1 PDK1 CXCR4 CXCR4 EP300 EP300 LONP1 LONP1 BAD BAD PLAU PLAU SMAD4 SMAD4 PPARD PPARD RYR1 RYR1 ARNT2 ARNT2 PLAT PLAT CHRNA4 CHRNA4 ENSUAMP00000032923 ENSUAMP00000032923 PML PML NPEPPS NPEPPS USF1 USF1 CBFA2T3 CBFA2T3 AQP3 AQP3 ENSUAMP00000034116 ENSUAMP00000034116 FAM167A FAM167A NOTCH1 NOTCH1 NOS1 NOS1 ENSUAMP00000017404 ENSUAMP00000017404 LMNA LMNA ENSUAMP00000017340 ENSUAMP00000017340 PGF PGF TGFB3 TGFB3 ENSUAMP00000035192 ENSUAMP00000035192 ENSUAMP00000035027 ENSUAMP00000035027 KCND1 KCND1 ENSUAMP00000034830 ENSUAMP00000034830 HIF1A HIF1A NDNF NDNF SLC11A2 SLC11A2 CIAO3 CIAO3 NFE2L2 NFE2L2 TIGAR TIGAR KCNMA1 KCNMA1 VASN VASN HMOX2 HMOX2 ENSUAMP00000005541 ENSUAMP00000005541 ALAS2 ALAS2 ENSUAMP00000004918 ENSUAMP00000004918 ENSUAMP00000004725 ENSUAMP00000004725 ENSUAMP00000004592 ENSUAMP00000004592 HIF3A HIF3A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000004728G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
MECP2Methyl-CpG binding protein 2. (440 aa)
SCAPSREBF chaperone. (1229 aa)
ENSUAMP00000025740Uncharacterized protein. (466 aa)
WDR83WD repeat domain 83. (315 aa)
RORARAR related orphan receptor A. (522 aa)
ENSUAMP00000024458Uncharacterized protein. (155 aa)
NDRG1N-myc downstream regulated 1. (364 aa)
NF1Neurofibromin 1. (2845 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
CRYABCrystallin alpha B; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (175 aa)
HIF1ANHypoxia inducible factor 1 subunit alpha inhibitor. (349 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
UCP2Uncoupling protein 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (309 aa)
ADAAdenosine deaminase. (385 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (499 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PLOD2Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2. (728 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
ANGPT4Angiopoietin 4. (446 aa)
EDN1Endothelin 1. (202 aa)
ENSUAMP00000030519Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (214 aa)
ENSUAMP00000030549Transmembrane 9 superfamily member; Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family. (85 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (329 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (194 aa)
ENSUAMP00000021600Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (203 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
P4HBProtein disulfide-isomerase. (510 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
NARFNuclear prelamin A recognition factor; Belongs to the NARF family. (456 aa)
MYOCDMyocardin. (870 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
AJUBAAjuba LIM protein. (548 aa)
ENSUAMP00000000439Uncharacterized protein. (456 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ADO2-aminoethanethiol dioxygenase. (270 aa)
ENSUAMP00000001189SHSP domain-containing protein; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. (179 aa)
LIMD1LIM domains containing 1. (672 aa)
ENSUAMP00000002924Uncharacterized protein. (335 aa)
ENSUAMP00000002943RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (169 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (483 aa)
ENSUAMP00000021701Fe2OG dioxygenase domain-containing protein. (233 aa)
ENSUAMP00000003645Uncharacterized protein. (122 aa)
HP1BP3Heterochromatin protein 1 binding protein 3. (515 aa)
EPAS1Endothelial PAS domain protein 1. (863 aa)
BACH1BTB domain and CNC homolog 1. (748 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (598 aa)
STOX1Storkhead box 1. (1069 aa)
PINK1PTEN induced kinase 1. (602 aa)
P2RX3P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (366 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (391 aa)
MGARPMitochondria localized glutamic acid rich protein. (243 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (426 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
ALKBH5AlkB homolog 5, RNA demethylase. (394 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (247 aa)
PLOD1Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1. (727 aa)
ARNTAryl hydrocarbon receptor nuclear translocator. (481 aa)
ENSUAMP00000012276B30.2/SPRY domain-containing protein. (334 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
ENSUAMP00000011731Ion_trans domain-containing protein. (408 aa)
BNIP3BCL2 interacting protein 3. (263 aa)
ENSUAMP00000011462Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
DDIT4DNA damage inducible transcript 4. (231 aa)
SIRT1Sirtuin 1. (618 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ENSUAMP00000008835Uncharacterized protein. (71 aa)
LOXL2Lysyl oxidase like 2. (779 aa)
ENSUAMP00000009578RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (169 aa)
ENSUAMP00000009775C2 domain-containing protein. (151 aa)
ENSUAMP00000021352Uncharacterized protein. (141 aa)
TBL2Transducin beta like 2. (446 aa)
ENSUAMP00000035193Uncharacterized protein. (279 aa)
ENSUAMP00000035681Protein kinase domain-containing protein. (217 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
PLEKHN1Pleckstrin homology domain containing N1. (656 aa)
HYOU1Hypoxia up-regulated 1. (996 aa)
ENSUAMP00000037224Fe2OG dioxygenase domain-containing protein. (126 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (469 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
AGERAdvanced glycosylation end-product specific receptor. (410 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (516 aa)
NOL3Nucleolar protein 3. (222 aa)
SRFSerum response factor. (507 aa)
HMOX1Heme oxygenase 1. (288 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (191 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
CXCR4C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (353 aa)
EP300E1A binding protein p300. (2399 aa)
LONP1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand- specific manner. May regulate mi [...] (961 aa)
BADBCL2 associated agonist of cell death. (168 aa)
PLAUPlasminogen activator, urokinase; Belongs to the peptidase S1 family. (432 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
RYR1Ryanodine receptor 1. (3775 aa)
ARNT2Aryl hydrocarbon receptor nuclear translocator 2. (706 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (563 aa)
CHRNA4Cholinergic receptor nicotinic alpha 4 subunit. (624 aa)
ENSUAMP00000032923Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
PMLPromyelocytic leukemia. (877 aa)
NPEPPSAminopeptidase. (921 aa)
USF1Upstream transcription factor 1. (373 aa)
CBFA2T3CBFA2/RUNX1 partner transcriptional co-repressor 3. (748 aa)
AQP3Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
ENSUAMP00000034116Uncharacterized protein. (571 aa)
FAM167AFamily with sequence similarity 167 member A. (210 aa)
NOTCH1Notch receptor 1. (2547 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1095 aa)
ENSUAMP00000017404Fe2OG dioxygenase domain-containing protein. (125 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (671 aa)
ENSUAMP00000017340Uncharacterized protein. (131 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSUAMP00000035192Uncharacterized protein. (82 aa)
ENSUAMP00000035027Uncharacterized protein. (146 aa)
KCND1Potassium voltage-gated channel subfamily D member 1; Belongs to the potassium channel family. (647 aa)
ENSUAMP00000034830Uncharacterized protein. (1872 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
NDNFNeuron derived neurotrophic factor. (568 aa)
SLC11A2Solute carrier family 11 member 2. (533 aa)
CIAO3Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (546 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (269 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1143 aa)
VASNVasorin. (676 aa)
HMOX2Heme oxygenase 2. (316 aa)
ENSUAMP00000005541P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (437 aa)
ALAS25-aminolevulinate synthase. (587 aa)
ENSUAMP00000004918Homeobox domain-containing protein. (230 aa)
ENSUAMP00000004725G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ENSUAMP00000004592MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (478 aa)
HIF3AHypoxia inducible factor 3 subunit alpha. (645 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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