STRINGSTRING
PRDM14 PRDM14 EMG1 EMG1 SOX17 SOX17 BYSL BYSL RBBP8 RBBP8 TAF8 TAF8 ENSUAMP00000000033 ENSUAMP00000000033 ENSUAMP00000000062 ENSUAMP00000000062 SMIM14 SMIM14 ENSUAMP00000000589 ENSUAMP00000000589 SBDS SBDS LATS2 LATS2 PSMC4 PSMC4 MED21 MED21 PELO PELO AKAP3 AKAP3 NPM2 NPM2 ENSUAMP00000003678 ENSUAMP00000003678 SUPT6H SUPT6H SLC25A34 SLC25A34 CNOT3 CNOT3 NCAPG2 NCAPG2 ENSUAMP00000006869 ENSUAMP00000006869 LATS1 LATS1 GABPA GABPA CHEK1 CHEK1 ENSUAMP00000008125 ENSUAMP00000008125 NEK2 NEK2 KPNA7 KPNA7 NODAL NODAL NASP NASP CNOT1 CNOT1 STMN3 STMN3 ENSUAMP00000012019 ENSUAMP00000012019 SALL4 SALL4 HORMAD1 HORMAD1 MFN2 MFN2 SMARCB1 SMARCB1 ENSUAMP00000013728 ENSUAMP00000013728 NLE1 NLE1 ENSUAMP00000014099 ENSUAMP00000014099 CUL3 CUL3 ZNF830 ZNF830 TGFBR1 TGFBR1 BRCA2 BRCA2 ENSUAMP00000018609 ENSUAMP00000018609 SKIL SKIL ARHGDIG ARHGDIG PNLDC1 PNLDC1 SRF SRF SPIC SPIC CNOT2 CNOT2 TM4SF1 TM4SF1 WDR74 WDR74 GINS4 GINS4 ADA ADA ACVR1C ACVR1C CITED2 CITED2 NBN NBN INTS1 INTS1 ENSUAMP00000024228 ENSUAMP00000024228 ZFP14 ZFP14 SP3 SP3 XAB2 XAB2 HAND1 HAND1 ENSUAMP00000025159 ENSUAMP00000025159 RTN4 RTN4 ENSUAMP00000025215 ENSUAMP00000025215 ENSUAMP00000025477 ENSUAMP00000025477 RAD51B RAD51B ZPR1 ZPR1 ASF1B ASF1B ELF3 ELF3 MFNG MFNG ENSUAMP00000026772 ENSUAMP00000026772 ENSUAMP00000026773 ENSUAMP00000026773 TEAD4 TEAD4 CTR9 CTR9 ENSUAMP00000027802 ENSUAMP00000027802 ENSUAMP00000028147 ENSUAMP00000028147 ENSUAMP00000028149 ENSUAMP00000028149 HNF1A HNF1A NDEL1 NDEL1 RTF1 RTF1 SLC35E2B SLC35E2B ENSUAMP00000031291 ENSUAMP00000031291 PLPP4 PLPP4 PHF6 PHF6 ENSUAMP00000034405 ENSUAMP00000034405 RRP7A RRP7A CCDC24 CCDC24 RBM46 RBM46
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRDM14PR/SET domain 14. (566 aa)
EMG1EMG1 N1-specific pseudouridine methyltransferase. (244 aa)
SOX17SRY-box transcription factor 17. (406 aa)
BYSLBystin like. (437 aa)
RBBP8RB binding protein 8, endonuclease. (873 aa)
TAF8TATA-box binding protein associated factor 8. (300 aa)
ENSUAMP00000000033Matrin-type domain-containing protein. (169 aa)
ENSUAMP00000000062Uncharacterized protein. (740 aa)
SMIM14Small integral membrane protein 14. (94 aa)
ENSUAMP00000000589Uncharacterized protein. (270 aa)
SBDSSBDS ribosome maturation factor. (250 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (400 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (144 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
AKAP3A-kinase anchoring protein 3. (510 aa)
NPM2Nucleophosmin/nucleoplasmin 2. (261 aa)
ENSUAMP00000003678Uncharacterized protein. (542 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
SLC25A34Solute carrier family 25 member 34; Belongs to the mitochondrial carrier (TC 2.A.29) family. (318 aa)
CNOT3CCR4-NOT transcription complex subunit 3. (749 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (867 aa)
ENSUAMP00000006869Uncharacterized protein. (392 aa)
LATS1Uncharacterized protein. (1012 aa)
GABPAGA binding protein transcription factor subunit alpha. (454 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
ENSUAMP00000008125ANK_REP_REGION domain-containing protein. (292 aa)
NEK2NIMA related kinase 2. (444 aa)
KPNA7Importin subunit alpha; Functions in nuclear protein import. (523 aa)
NODALNodal growth differentiation factor. (348 aa)
NASPNuclear autoantigenic sperm protein. (669 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2376 aa)
STMN3Stathmin; Belongs to the stathmin family. (179 aa)
ENSUAMP00000012019Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (104 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
HORMAD1HORMA domain containing 1. (390 aa)
MFN2Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (757 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
ENSUAMP00000013728RING-type domain-containing protein. (102 aa)
NLE1Notchless homolog 1. (477 aa)
ENSUAMP00000014099ZP domain-containing protein. (417 aa)
CUL3Cullin 3; Belongs to the cullin family. (766 aa)
ZNF830Zinc finger protein 830. (370 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
BRCA2BRCA2 DNA repair associated. (3458 aa)
ENSUAMP00000018609ZP domain-containing protein. (160 aa)
SKILSKI like proto-oncogene. (684 aa)
ARHGDIGRho GDP dissociation inhibitor gamma. (220 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (529 aa)
SRFSerum response factor. (507 aa)
SPICSpi-C transcription factor. (230 aa)
CNOT2CCR4-NOT transcription complex subunit 2. (520 aa)
TM4SF1Transmembrane 4 L six family member 1. (223 aa)
WDR74WD repeat domain 74. (382 aa)
GINS4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (233 aa)
ADAAdenosine deaminase. (385 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (494 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
INTS1Integrator complex subunit 1. (2188 aa)
ENSUAMP00000024228MARVEL domain-containing protein. (96 aa)
ZFP14ZFP14 zinc finger protein. (532 aa)
SP3Sp3 transcription factor. (780 aa)
XAB2XPA binding protein 2. (855 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
ENSUAMP00000025159BZIP domain-containing protein. (314 aa)
RTN4Reticulon. (951 aa)
ENSUAMP00000025215BZIP domain-containing protein. (347 aa)
ENSUAMP00000025477Uncharacterized protein. (185 aa)
RAD51BRAD51 paralog B. (271 aa)
ZPR1ZPR1 zinc finger. (460 aa)
ASF1BAnti-silencing function 1B histone chaperone. (202 aa)
ELF3E74 like ETS transcription factor 3. (369 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase. (321 aa)
ENSUAMP00000026772ETS domain-containing protein. (163 aa)
ENSUAMP00000026773Uncharacterized protein. (179 aa)
TEAD4TEA domain transcription factor 4. (353 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
ENSUAMP00000027802Uncharacterized protein; Belongs to the peptidase C2 family. (706 aa)
ENSUAMP00000028147Uncharacterized protein. (74 aa)
ENSUAMP00000028149Calpain catalytic domain-containing protein; Belongs to the peptidase C2 family. (67 aa)
HNF1AHNF1 homeobox A. (631 aa)
NDEL1NudE neurodevelopment protein 1 like 1. (345 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (424 aa)
SLC35E2BSolute carrier family 35 member E2B. (405 aa)
ENSUAMP00000031291Protein kinase domain-containing protein. (725 aa)
PLPP4Phospholipid phosphatase 4. (267 aa)
PHF6PHD finger protein 6. (365 aa)
ENSUAMP00000034405Uncharacterized protein. (207 aa)
RRP7ARibosomal RNA processing 7 homolog A. (280 aa)
CCDC24Coiled-coil domain containing 24. (315 aa)
RBM46RNA binding motif protein 46. (533 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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