75 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PKD2	Polycystin 2, transient receptor potential cation channel. (897 aa)
	ELK1	ETS transcription factor ELK1. (435 aa)
	CEBPB	CCAAT/enhancer-binding protein. (346 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (508 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	SOX9	SRY-box transcription factor 9. (484 aa)
	JARID2	Jumonji and AT-rich interaction domain containing 2. (1160 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	SULF2	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
	FRZB	Frizzled related protein. (298 aa)
	GLI1	GLI family zinc finger 1. (1105 aa)
	SP3	Sp3 transcription factor. (780 aa)
	ENSUAMP00000022564	HNF-1B_C domain-containing protein. (134 aa)
	ADA	Adenosine deaminase. (385 aa)
	SEC63	SEC63 homolog, protein translocation regulator. (686 aa)
	CDK5RAP3	CDK5 regulatory subunit associated protein 3. (504 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (474 aa)
	RB1CC1	RB1 inducible coiled-coil 1. (1273 aa)
	ENSUAMP00000020604	Uncharacterized protein. (334 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	ENSUAMP00000017162	Uncharacterized protein. (137 aa)
	ENSUAMP00000017043	HNF-1_N domain-containing protein. (138 aa)
	RPGRIP1L	RPGRIP1 like. (1207 aa)
	ENSUAMP00000015788	BZIP domain-containing protein. (359 aa)
	RHBDD3	Rhomboid domain containing 3. (386 aa)
	ACADM	Acyl-CoA dehydrogenase medium chain. (421 aa)
	ARF6	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
	CUL3	Cullin 3; Belongs to the cullin family. (766 aa)
	FGL1	Fibrinogen like 1. (312 aa)
	SMARCB1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
	COBL	Cordon-bleu WH2 repeat protein. (1250 aa)
	ENSUAMP00000011008	Uncharacterized protein. (538 aa)
	ENSUAMP00000010997	TPR_REGION domain-containing protein. (150 aa)
	CADM1	Cell adhesion molecule 1. (339 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	HES1	Hes family bHLH transcription factor 1. (259 aa)
	MET	MET proto-oncogene, receptor tyrosine kinase. (1399 aa)
	CEBPG	CCAAT enhancer binding protein gamma. (147 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	PTCD2	Pentatricopeptide repeat domain 2. (427 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
	ENSUAMP00000008067	BAAT_C domain-containing protein. (197 aa)
	E2F8	E2F transcription factor 8. (863 aa)
	MAN2A1	Alpha-mannosidase. (1096 aa)
	ENSUAMP00000006610	CUT domain-containing protein. (259 aa)
	ENSUAMP00000006083	Dynein assembly factor 1, axonemal. (316 aa)
	ANXA1	Annexin. (345 aa)
	LSR	Lipolysis stimulated lipoprotein receptor. (595 aa)
	ENSUAMP00000003258	Uncharacterized protein. (246 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	ENSUAMP00000001020	Uncharacterized protein. (147 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	HNF1A	HNF1 homeobox A. (631 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
	NF1	Neurofibromin 1. (2845 aa)
	ENSUAMP00000023691	Uncharacterized protein. (268 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	ENSUAMP00000036960	Uncharacterized protein. (136 aa)
	ENSUAMP00000036959	Uncharacterized protein. (563 aa)
	ENSUAMP00000036515	Uncharacterized protein. (78 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	ENSUAMP00000036217	Uncharacterized protein. (186 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
	HLX	H2.0 like homeobox. (454 aa)
	NOTCH2	Notch receptor 2. (2374 aa)
	TAF10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (199 aa)
	C6orf58	Chromosome 6 open reading frame 58. (314 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (640 aa)
	IL6	Interleukin 6. (212 aa)
	UPF2	UPF2 regulator of nonsense mediated mRNA decay. (1205 aa)
	PDX1	Pancreatic and duodenal homeobox 1. (282 aa)
	ZIC3	Uncharacterized protein. (466 aa)
	GFER	Sulfhydryl oxidase. (206 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA1	IL6	ENSUAMP00000005904	ENSUAMP00000030975	Annexin.	Interleukin 6.	0.469
ARF6	ENSUAMP00000023691	ENSUAMP00000015520	ENSUAMP00000023691	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein.	0.594
ARF6	MET	ENSUAMP00000015520	ENSUAMP00000009382	ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family.	MET proto-oncogene, receptor tyrosine kinase.	0.855
ATF2	CEBPG	ENSUAMP00000010037	ENSUAMP00000009126	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	CCAAT enhancer binding protein gamma.	0.464
ATF2	JUN	ENSUAMP00000010037	ENSUAMP00000009019	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.994
CEBPB	CEBPG	ENSUAMP00000027268	ENSUAMP00000009126	CCAAT/enhancer-binding protein.	CCAAT enhancer binding protein gamma.	0.956
CEBPB	ENSUAMP00000015788	ENSUAMP00000027268	ENSUAMP00000015788	CCAAT/enhancer-binding protein.	BZIP domain-containing protein.	0.586
CEBPB	IL6	ENSUAMP00000027268	ENSUAMP00000030975	CCAAT/enhancer-binding protein.	Interleukin 6.	0.610
CEBPB	JUN	ENSUAMP00000027268	ENSUAMP00000009019	CCAAT/enhancer-binding protein.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.691
CEBPB	RELA	ENSUAMP00000027268	ENSUAMP00000026886	CCAAT/enhancer-binding protein.	RELA proto-oncogene, NF-kB subunit.	0.811
CEBPB	SMAD3	ENSUAMP00000027268	ENSUAMP00000026563	CCAAT/enhancer-binding protein.	Mothers against decapentaplegic homolog.	0.444
CEBPG	ATF2	ENSUAMP00000009126	ENSUAMP00000010037	CCAAT enhancer binding protein gamma.	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	0.464
CEBPG	CEBPB	ENSUAMP00000009126	ENSUAMP00000027268	CCAAT enhancer binding protein gamma.	CCAAT/enhancer-binding protein.	0.956
CEBPG	ENSUAMP00000015788	ENSUAMP00000009126	ENSUAMP00000015788	CCAAT enhancer binding protein gamma.	BZIP domain-containing protein.	0.429
CEBPG	JUN	ENSUAMP00000009126	ENSUAMP00000009019	CCAAT enhancer binding protein gamma.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.400
CUL3	GLI1	ENSUAMP00000015245	ENSUAMP00000024684	Cullin 3; Belongs to the cullin family.	GLI family zinc finger 1.	0.953
CUL3	NF1	ENSUAMP00000015245	ENSUAMP00000024136	Cullin 3; Belongs to the cullin family.	Neurofibromin 1.	0.465
E2F8	ENSUAMP00000036959	ENSUAMP00000007370	ENSUAMP00000036959	E2F transcription factor 8.	Uncharacterized protein.	0.926
E2F8	ENSUAMP00000036960	ENSUAMP00000007370	ENSUAMP00000036960	E2F transcription factor 8.	Uncharacterized protein.	0.926
ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	Uncharacterized protein.	Uncharacterized protein.	0.671