30 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SYNJ2BP	Synaptojanin 2 binding protein. (142 aa)
	PDCD10	Programmed cell death 10. (212 aa)
	APOH	Apolipoprotein H. (345 aa)
	THBS1	Thrombospondin 1. (1170 aa)
	ATP5F1A	ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. (578 aa)
	NGFR	Nerve growth factor receptor. (388 aa)
	NF1	Neurofibromin 1. (2845 aa)
	ALOX5	Arachidonate 5-lipoxygenase. (674 aa)
	CNMD	Chondromodulin. (340 aa)
	SULF1	Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (940 aa)
	ENSUAMP00000027914	Uncharacterized protein. (75 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	FLT1	Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1265 aa)
	APOE	Apolipoprotein E. (323 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
	AIMP1	Aminoacyl tRNA synthetase complex interacting multifunctional protein 1. (320 aa)
	GHRL	Ghrelin and obestatin prepropeptide. (134 aa)
	ENSUAMP00000033583	Uncharacterized protein. (659 aa)
	STAT1	Signal transducer and activator of transcription. (824 aa)
	GDF2	Growth differentiation factor 2. (429 aa)
	ENSUAMP00000001068	Ig-like domain-containing protein. (174 aa)
	TNMD	Tenomodulin. (310 aa)
	CAV2	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	VASH1	Vasohibin 1. (289 aa)
	ATOH8	Atonal bHLH transcription factor 8. (322 aa)
	TBC1D31	TBC1 domain family member 31. (923 aa)
	TNF	Tumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	GDF2	ENSUAMP00000017504	ENSUAMP00000000160	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Growth differentiation factor 2.	0.995
ACVRL1	TGFBR1	ENSUAMP00000017504	ENSUAMP00000016865	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.525
APOE	APOH	ENSUAMP00000030573	ENSUAMP00000021985	Apolipoprotein E.	Apolipoprotein H.	0.703
APOE	CAV1	ENSUAMP00000030573	ENSUAMP00000008607	Apolipoprotein E.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.631
APOE	STAT1	ENSUAMP00000030573	ENSUAMP00000034383	Apolipoprotein E.	Signal transducer and activator of transcription.	0.454
APOE	TNF	ENSUAMP00000030573	ENSUAMP00000015695	Apolipoprotein E.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.591
APOH	APOE	ENSUAMP00000021985	ENSUAMP00000030573	Apolipoprotein H.	Apolipoprotein E.	0.703
CAV1	APOE	ENSUAMP00000008607	ENSUAMP00000030573	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Apolipoprotein E.	0.631
CAV1	CAV2	ENSUAMP00000008607	ENSUAMP00000008605	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.999
CAV1	STAT1	ENSUAMP00000008607	ENSUAMP00000034383	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Signal transducer and activator of transcription.	0.420
CAV1	TGFBR1	ENSUAMP00000008607	ENSUAMP00000016865	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.513
CAV1	TNF	ENSUAMP00000008607	ENSUAMP00000015695	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Tumor necrosis factor; Belongs to the tumor necrosis factor family.	0.449
CAV2	CAV1	ENSUAMP00000008605	ENSUAMP00000008607	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.999
ENSUAMP00000027914	TBC1D31	ENSUAMP00000027914	ENSUAMP00000015678	Uncharacterized protein.	TBC1 domain family member 31.	0.865
ENSUAMP00000033583	PDCD10	ENSUAMP00000033583	ENSUAMP00000021850	Uncharacterized protein.	Programmed cell death 10.	0.847
GDF2	ACVRL1	ENSUAMP00000000160	ENSUAMP00000017504	Growth differentiation factor 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.995
GDF2	PDCD10	ENSUAMP00000000160	ENSUAMP00000021850	Growth differentiation factor 2.	Programmed cell death 10.	0.402
GDF2	TGFBR1	ENSUAMP00000000160	ENSUAMP00000016865	Growth differentiation factor 2.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.656
PDCD10	ENSUAMP00000033583	ENSUAMP00000021850	ENSUAMP00000033583	Programmed cell death 10.	Uncharacterized protein.	0.847
PDCD10	GDF2	ENSUAMP00000021850	ENSUAMP00000000160	Programmed cell death 10.	Growth differentiation factor 2.	0.402