STRINGSTRING
AKT3 AKT3 AKT1 AKT1 PRKCA PRKCA VASH2 VASH2 PRKD1 PRKD1 ENSUAMP00000009578 ENSUAMP00000009578 JUN JUN STAT3 STAT3 FGF10 FGF10 CDH13 CDH13 ENSUAMP00000006607 ENSUAMP00000006607 FLT4 FLT4 PDGFB PDGFB SCG2 SCG2 ENSUAMP00000003693 ENSUAMP00000003693 VIP VIP FGFBP1 FGFBP1 ENSUAMP00000002943 ENSUAMP00000002943 PROX1 PROX1 CCL24 CCL24 JCAD JCAD IL10 IL10 GDF2 GDF2 HTR2B HTR2B PDCD6 PDCD6 BMP4 BMP4 ENSUAMP00000029322 ENSUAMP00000029322 THBS4 THBS4 EGR3 EGR3 MYDGF MYDGF ENSUAMP00000034912 ENSUAMP00000034912 PROK1 PROK1 ENSUAMP00000036324 ENSUAMP00000036324 BMPR2 BMPR2 ENSUAMP00000037141 ENSUAMP00000037141 AKT2 AKT2 F3 F3 NRARP NRARP ENSUAMP00000026993 ENSUAMP00000026993 ZNF580 ZNF580 ENSUAMP00000025300 ENSUAMP00000025300 ENSUAMP00000025050 ENSUAMP00000025050 SIRT6 SIRT6 LRG1 LRG1 NF1 NF1 KDR KDR CCL26 CCL26 BMP2 BMP2 PRKD2 PRKD2 SIRT1 SIRT1 VEGFA VEGFA HMOX1 HMOX1 PIK3CD PIK3CD VEGFB VEGFB ENSUAMP00000019227 ENSUAMP00000019227 ECM1 ECM1 EMC10 EMC10 ACVRL1 ACVRL1 PGF PGF TGFBR1 TGFBR1 ENSUAMP00000016646 ENSUAMP00000016646 PDPK1 PDPK1 ENSUAMP00000016192 ENSUAMP00000016192 ENSUAMP00000015993 ENSUAMP00000015993 FGF7 FGF7 APLNR APLNR VEGFC VEGFC STAT5A STAT5A SP1 SP1 PDCL3 PDCL3 ENSUAMP00000012642 ENSUAMP00000012642
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
VASH2Vasohibin 2. (392 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (848 aa)
ENSUAMP00000009578RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (169 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
CDH13Cadherin 13. (495 aa)
ENSUAMP00000006607Uncharacterized protein. (215 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1363 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
SCG2Secretogranin II. (618 aa)
ENSUAMP00000003693Uncharacterized protein. (166 aa)
VIPVasoactive intestinal peptide. (170 aa)
FGFBP1Fibroblast growth factor binding protein 1. (255 aa)
ENSUAMP00000002943RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (169 aa)
PROX1Prospero homeobox 1. (737 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
JCADJunctional cadherin 5 associated. (1372 aa)
IL10Interleukin 10. (178 aa)
GDF2Growth differentiation factor 2. (429 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
PDCD6Programmed cell death 6. (189 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
THBS4Thrombospondin 4. (944 aa)
EGR3Early growth response 3. (387 aa)
MYDGFMyeloid derived growth factor. (173 aa)
ENSUAMP00000034912Uncharacterized protein. (714 aa)
PROK1Prokineticin 1. (105 aa)
ENSUAMP00000036324Uncharacterized protein. (189 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
ENSUAMP00000037141Uncharacterized protein. (54 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (288 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
ENSUAMP00000026993Uncharacterized protein. (118 aa)
ZNF580Zinc finger protein 580. (199 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
ENSUAMP00000025050Uncharacterized protein. (456 aa)
SIRT6Sirtuin 6. (338 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (354 aa)
NF1Neurofibromin 1. (2845 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1282 aa)
CCL26C-C motif chemokine. (92 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (840 aa)
SIRT1Sirtuin 1. (618 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (516 aa)
HMOX1Heme oxygenase 1. (288 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (191 aa)
ENSUAMP00000019227Uncharacterized protein. (61 aa)
ECM1Extracellular matrix protein 1. (422 aa)
EMC10ER membrane protein complex subunit 10. (254 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
ENSUAMP00000016646Uncharacterized protein. (167 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
ENSUAMP00000016192Integrin beta; Belongs to the integrin beta chain family. (786 aa)
ENSUAMP00000015993Uncharacterized protein. (98 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (391 aa)
STAT5ASignal transducer and activator of transcription. (797 aa)
SP1Sp1 transcription factor. (780 aa)
PDCL3Phosducin like 3. (222 aa)
ENSUAMP00000012642Integrin_alpha2 domain-containing protein. (261 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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