STRINGSTRING
MSX1 MSX1 TP53 TP53 ANKRD1 ANKRD1 MAPKAPK5 MAPKAPK5 ENSUAMP00000001879 ENSUAMP00000001879 USP10 USP10 NUAK1 NUAK1 CHD8 CHD8 ENSUAMP00000006800 ENSUAMP00000006800 TP63 TP63 MDM4 MDM4 BCL2L12 BCL2L12 RNF125 RNF125 PRMT5 PRMT5 ENSUAMP00000010535 ENSUAMP00000010535 TP53BP2 TP53BP2 GATA1 GATA1 SMYD2 SMYD2 GSK3B GSK3B SMARCB1 SMARCB1 ENSUAMP00000013528 ENSUAMP00000013528 TEP1 TEP1 MUL1 MUL1 TP73 TP73 ENSUAMP00000015093 ENSUAMP00000015093 ENSUAMP00000015102 ENSUAMP00000015102 PSME3 PSME3 ARMCX2 ARMCX2 ARMCX3 ARMCX3 RNF34 RNF34 ENSUAMP00000019612 ENSUAMP00000019612 AXIN1 AXIN1 TRIM24 TRIM24 TRIM29 TRIM29 CDKN2AIP CDKN2AIP SIRT1 SIRT1 RCHY1 RCHY1 ENSUAMP00000023419 ENSUAMP00000023419 ENSUAMP00000023422 ENSUAMP00000023422 MDM2 MDM2 TAF3 TAF3 KMT5A KMT5A HTT HTT USP7 USP7 ENSUAMP00000026418 ENSUAMP00000026418 ENSUAMP00000026725 ENSUAMP00000026725 RNF20 RNF20 ENSUAMP00000027429 ENSUAMP00000027429 ENSUAMP00000027431 ENSUAMP00000027431 TP53BP1 TP53BP1 TP53RK TP53RK ZNF385A ZNF385A POU4F2 POU4F2 RFFL RFFL SETD7 SETD7 CDK5 CDK5 CREBBP CREBBP EP300 EP300 EHMT2 EHMT2 BRD7 BRD7 NTRK3 NTRK3 HIF1A HIF1A ENSUAMP00000034862 ENSUAMP00000034862 DUSP26 DUSP26 DAXX DAXX NOP53 NOP53
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MSX1Msh homeobox 1. (303 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
MAPKAPK5MAPK activated protein kinase 5. (456 aa)
ENSUAMP00000001879Protein kinase domain-containing protein. (335 aa)
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (793 aa)
NUAK1NUAK family kinase 1. (671 aa)
CHD8Chromodomain helicase DNA binding protein 8. (1832 aa)
ENSUAMP00000006800Uncharacterized protein. (97 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
MDM4Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. (492 aa)
BCL2L12BCL2 like 12. (323 aa)
RNF125Ring finger protein 125. (232 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
ENSUAMP00000010535Uncharacterized protein. (406 aa)
TP53BP2Tumor protein p53 binding protein 2. (1157 aa)
GATA1GATA binding protein 1. (413 aa)
SMYD2SET and MYND domain containing 2. (439 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
ENSUAMP00000013528U1-type domain-containing protein. (104 aa)
TEP1Telomerase associated protein 1. (2614 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (252 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (634 aa)
ENSUAMP00000015093Uncharacterized protein. (1064 aa)
ENSUAMP00000015102Uncharacterized protein. (121 aa)
PSME3Proteasome activator subunit 3. (254 aa)
ARMCX2Armadillo repeat containing X-linked 2. (615 aa)
ARMCX3Armadillo repeat containing X-linked 3. (379 aa)
RNF34Ring finger protein 34. (376 aa)
ENSUAMP00000019612Uncharacterized protein. (76 aa)
AXIN1Axin 1. (867 aa)
TRIM24Tripartite motif containing 24. (1021 aa)
TRIM29Tripartite motif containing 29. (585 aa)
CDKN2AIPCDKN2A interacting protein. (571 aa)
SIRT1Sirtuin 1. (618 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
ENSUAMP00000023419SET domain-containing protein. (162 aa)
ENSUAMP00000023422ANK_REP_REGION domain-containing protein. (975 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (495 aa)
TAF3TATA-box binding protein associated factor 3. (621 aa)
KMT5ALysine methyltransferase 5A. (327 aa)
HTTHuntingtin. (3059 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1055 aa)
ENSUAMP00000026418Uncharacterized protein. (83 aa)
ENSUAMP00000026725SEA domain-containing protein. (629 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
ENSUAMP00000027429Uncharacterized protein. (165 aa)
ENSUAMP00000027431Uncharacterized protein. (74 aa)
TP53BP1Tumor protein p53 binding protein 1. (1542 aa)
TP53RKTP53 regulating kinase. (254 aa)
ZNF385AZinc finger protein 385A. (386 aa)
POU4F2POU domain protein. (408 aa)
RFFLRing finger and FYVE like domain containing E3 ubiquitin protein ligase. (376 aa)
SETD7Histone-lysine N-methyltransferase SETD7; Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes. (366 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
CREBBPCREB binding protein. (2333 aa)
EP300E1A binding protein p300. (2399 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1294 aa)
BRD7Bromodomain containing 7. (674 aa)
NTRK3Tyrosine-protein kinase receptor. (784 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
ENSUAMP00000034862PSI domain-containing protein. (187 aa)
DUSP26Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
DAXXDeath domain associated protein. (756 aa)
NOP53Ribosome biogenesis protein NOP53; May play a role in ribosome biogenesis. Belongs to the NOP53 family. (469 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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