46 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000000316	Homeobox domain-containing protein. (280 aa)
	ENSUAMP00000000397	Paired domain-containing protein. (216 aa)
	ENSUAMP00000001245	CTF/NF-I domain-containing protein. (195 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	SIDT2	SID1 transmembrane family member 2. (832 aa)
	CLCN2	Chloride channel protein. (903 aa)
	NKX6-1	NK6 homeobox 1. (366 aa)
	ENSUAMP00000006989	CTF/NF-I domain-containing protein. (213 aa)
	SLC9A4	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (776 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	ENSUAMP00000009377	Uncharacterized protein. (170 aa)
	HES1	Hes family bHLH transcription factor 1. (259 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (213 aa)
	GPAT4	Glycerol-3-phosphate acyltransferase 4. (456 aa)
	ENSUAMP00000010818	Homeobox domain-containing protein. (263 aa)
	ENSUAMP00000012044	TGF_BETA_2 domain-containing protein. (154 aa)
	RARB	Retinoic acid receptor beta. (336 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
	FOXA1	Forkhead box A1. (472 aa)
	PAX4	Paired box 4. (357 aa)
	PDPK1	3-phosphoinositide dependent protein kinase 1. (531 aa)
	LHX3	LIM homeobox 3. (403 aa)
	HOXA5	Homeobox A5. (381 aa)
	WDR77	WD repeat domain 77. (342 aa)
	GDF11	Growth differentiation factor 11. (409 aa)
	RBM4	RNA binding motif protein 4. (365 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (474 aa)
	BHLHA15	Basic helix-loop-helix family member a15. (187 aa)
	ENSUAMP00000025477	Uncharacterized protein. (185 aa)
	SPDEF	SAM pointed domain containing ETS transcription factor. (335 aa)
	SOX9	SRY-box transcription factor 9. (484 aa)
	NKX6-2	NK6 homeobox 2. (269 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	DLL1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (757 aa)
	ENSUAMP00000029322	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
	IL31RA	Interleukin 31 receptor A. (728 aa)
	PDX1	Pancreatic and duodenal homeobox 1. (282 aa)
	AGR2	Anterior gradient 2, protein disulphide isomerase family member. (196 aa)
	FASN	Fatty acid synthase. (2519 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (823 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGR2	FOXA1	ENSUAMP00000032301	ENSUAMP00000014538	Anterior gradient 2, protein disulphide isomerase family member.	Forkhead box A1.	0.452
AGR2	SPDEF	ENSUAMP00000032301	ENSUAMP00000025667	Anterior gradient 2, protein disulphide isomerase family member.	SAM pointed domain containing ETS transcription factor.	0.593
ASCL1	DLL1	ENSUAMP00000010094	ENSUAMP00000028916	Achaete-scute family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.502
ASCL1	ENSUAMP00000000316	ENSUAMP00000010094	ENSUAMP00000000316	Achaete-scute family bHLH transcription factor 1.	Homeobox domain-containing protein.	0.528
ASCL1	ENSUAMP00000000397	ENSUAMP00000010094	ENSUAMP00000000397	Achaete-scute family bHLH transcription factor 1.	Paired domain-containing protein.	0.528
ASCL1	ENSUAMP00000029322	ENSUAMP00000010094	ENSUAMP00000029322	Achaete-scute family bHLH transcription factor 1.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.405
ASCL1	HES1	ENSUAMP00000010094	ENSUAMP00000009424	Achaete-scute family bHLH transcription factor 1.	Hes family bHLH transcription factor 1.	0.432
ASCL1	LHX3	ENSUAMP00000010094	ENSUAMP00000016925	Achaete-scute family bHLH transcription factor 1.	LIM homeobox 3.	0.469
ASCL1	SOX9	ENSUAMP00000010094	ENSUAMP00000026554	Achaete-scute family bHLH transcription factor 1.	SRY-box transcription factor 9.	0.625
BMP2	BMP4	ENSUAMP00000021596	ENSUAMP00000028868	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.943
BMP2	ENSUAMP00000012044	ENSUAMP00000021596	ENSUAMP00000012044	Bone morphogenetic protein 2.	TGF_BETA_2 domain-containing protein.	0.730
BMP2	ENSUAMP00000029322	ENSUAMP00000021596	ENSUAMP00000029322	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.721
BMP2	RARG	ENSUAMP00000021596	ENSUAMP00000003570	Bone morphogenetic protein 2.	Retinoic acid receptor gamma.	0.465
BMP2	SOX9	ENSUAMP00000021596	ENSUAMP00000026554	Bone morphogenetic protein 2.	SRY-box transcription factor 9.	0.578
BMP4	BMP2	ENSUAMP00000028868	ENSUAMP00000021596	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.943
BMP4	ENSUAMP00000000316	ENSUAMP00000028868	ENSUAMP00000000316	Bone morphogenetic protein 4.	Homeobox domain-containing protein.	0.460
BMP4	ENSUAMP00000000397	ENSUAMP00000028868	ENSUAMP00000000397	Bone morphogenetic protein 4.	Paired domain-containing protein.	0.460
BMP4	ENSUAMP00000012044	ENSUAMP00000028868	ENSUAMP00000012044	Bone morphogenetic protein 4.	TGF_BETA_2 domain-containing protein.	0.778
BMP4	ENSUAMP00000029322	ENSUAMP00000028868	ENSUAMP00000029322	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.753
BMP4	NOTCH1	ENSUAMP00000028868	ENSUAMP00000034225	Bone morphogenetic protein 4.	Notch receptor 1.	0.426