STRINGSTRING
ENSUAMP00000012758 ENSUAMP00000012758 HTR2B HTR2B CCDC103 CCDC103 ENSUAMP00000000600 ENSUAMP00000000600 MSX1 MSX1 ENSUAMP00000000737 ENSUAMP00000000737 ENSUAMP00000000744 ENSUAMP00000000744 TP53 TP53 PKP2 PKP2 ANKRD1 ANKRD1 AXIN2 AXIN2 ADGRG6 ADGRG6 TBX2 TBX2 NOG NOG FZD2 FZD2 PROX1 PROX1 TBX5 TBX5 WNT11 WNT11 ADAMTS1 ADAMTS1 FLNA FLNA ENSUAMP00000003003 ENSUAMP00000003003 ENSUAMP00000003258 ENSUAMP00000003258 NKX2-5 NKX2-5 ENSUAMP00000003640 ENSUAMP00000003640 NSD2 NSD2 ENSUAMP00000004638 ENSUAMP00000004638 ENSUAMP00000004725 ENSUAMP00000004725 ENSUAMP00000004728 ENSUAMP00000004728 TAB1 TAB1 ENSUAMP00000005111 ENSUAMP00000005111 ENSUAMP00000005311 ENSUAMP00000005311 TNNI1 TNNI1 ENSUAMP00000005686 ENSUAMP00000005686 ENSUAMP00000005691 ENSUAMP00000005691 PARVA PARVA ENSUAMP00000006083 ENSUAMP00000006083 MKS1 MKS1 MESP2 MESP2 ENSUAMP00000007313 ENSUAMP00000007313 ENSUAMP00000007316 ENSUAMP00000007316 MICAL2 MICAL2 HAND2 HAND2 TNNC1 TNNC1 ENSUAMP00000007554 ENSUAMP00000007554 FOXH1 FOXH1 PTCH1 PTCH1 CRKL CRKL TEAD2 TEAD2 JUN JUN PTCD2 PTCD2 GATA4 GATA4 SEC24B SEC24B HES1 HES1 SOX4 SOX4 WNT2 WNT2 TBX19 TBX19 NODAL NODAL ENSUAMP00000010013 ENSUAMP00000010013 ATF2 ATF2 ENSUAMP00000010093 ENSUAMP00000010093 ENSUAMP00000010224 ENSUAMP00000010224 TGFBR3 TGFBR3 EMP2 EMP2 ENSUAMP00000010858 ENSUAMP00000010858 ENSUAMP00000010867 ENSUAMP00000010867 ENSUAMP00000010997 ENSUAMP00000010997 ENSUAMP00000011008 ENSUAMP00000011008 TCAP TCAP ADPRH ADPRH ENSUAMP00000012276 ENSUAMP00000012276 EXT1 EXT1 MEGF8 MEGF8 ENSUAMP00000013328 ENSUAMP00000013328 APLNR APLNR ENSUAMP00000015215 ENSUAMP00000015215 ENSUAMP00000015361 ENSUAMP00000015361 BMP10 BMP10 FOXF1 FOXF1 ARID2 ARID2 CPE CPE TGFBR1 TGFBR1 ENSUAMP00000017162 ENSUAMP00000017162 ACVRL1 ACVRL1 TEK TEK MIB1 MIB1 ENSUAMP00000017830 ENSUAMP00000017830 ADAM15 ADAM15 FLRT2 FLRT2 SMAD4 SMAD4 DVL2 DVL2 NIPBL NIPBL ENSUAMP00000018820 ENSUAMP00000018820 GATA5 GATA5 MYBPC3 MYBPC3 SYNPO2L SYNPO2L ZFPM2 ZFPM2 MTOR MTOR SRF SRF EYA1 EYA1 ENSUAMP00000020431 ENSUAMP00000020431 TGFB2 TGFB2 DLL4 DLL4 NRP2 NRP2 HAS2 HAS2 GJA5 GJA5 BMP2 BMP2 NPY5R NPY5R NPY1R NPY1R WNT16 WNT16 C2CD3 C2CD3 INSR INSR CITED2 CITED2 CCN1 CCN1 ENSUAMP00000024427 ENSUAMP00000024427 LRP2 LRP2 HAND1 HAND1 DHRS3 DHRS3 RTN4 RTN4 XIRP2 XIRP2 SEMA3C SEMA3C ENSUAMP00000025477 ENSUAMP00000025477 TBX20 TBX20 PPP1R13L PPP1R13L SOX9 SOX9 SMAD3 SMAD3 SMAD6 SMAD6 EFNA1 EFNA1 SMAD7 SMAD7 SMO SMO TGFBR3L TGFBR3L IHH IHH ENSUAMP00000028668 ENSUAMP00000028668 GATA3 GATA3 BMP4 BMP4 DLL1 DLL1 TBXT TBXT SMARCD3 SMARCD3 PKD2 PKD2 MEF2C MEF2C SLIT3 SLIT3 ZIC3 ZIC3 ENG ENG ENSUAMP00000030304 ENSUAMP00000030304 EDN1 EDN1 ENSUAMP00000030480 ENSUAMP00000030480 CCM2L CCM2L MYLK2 MYLK2 ASXL1 ASXL1 MYL2 MYL2 LBX1 LBX1 TBX6 TBX6 TMEM100 TMEM100 CAV3 CAV3 ASB2 ASB2 SAV1 SAV1 SOS1 SOS1 AHI1 AHI1 ILK ILK NOTCH2 NOTCH2 CHD7 CHD7 FHL2 FHL2 MED1 MED1 ARL13B ARL13B NOTCH1 NOTCH1 CLUAP1 CLUAP1 HIF1A HIF1A JAG1 JAG1 IFT52 IFT52 SNAI1 SNAI1 MYL10 MYL10 ENSUAMP00000035960 ENSUAMP00000035960 BMPR1A BMPR1A ENSUAMP00000036217 ENSUAMP00000036217 GAA GAA ZMPSTE24 ZMPSTE24 SOX17 SOX17 BMPR2 BMPR2 KDM6A KDM6A ZMIZ1 ZMIZ1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000012758START domain-containing protein. (327 aa)
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
CCDC103Coiled-coil domain containing 103. (242 aa)
ENSUAMP00000000600Uncharacterized protein. (130 aa)
MSX1Msh homeobox 1. (303 aa)
ENSUAMP00000000737Uncharacterized protein. (81 aa)
ENSUAMP00000000744Uncharacterized protein. (157 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
PKP2Plakophilin 2. (829 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
AXIN2Axin 2. (843 aa)
ADGRG6Adhesion G protein-coupled receptor G6; Belongs to the G-protein coupled receptor 2 family. (1210 aa)
TBX2T-box transcription factor 2. (697 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
PROX1Prospero homeobox 1. (737 aa)
TBX5T-box transcription factor 5. (517 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
FLNAFilamin A. (1660 aa)
ENSUAMP00000003003Plexin_cytopl domain-containing protein. (490 aa)
ENSUAMP00000003258Uncharacterized protein. (246 aa)
NKX2-5NK2 homeobox 5. (323 aa)
ENSUAMP00000003640Uncharacterized protein. (101 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1344 aa)
ENSUAMP00000004638Uncharacterized protein. (148 aa)
ENSUAMP00000004725G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ENSUAMP00000004728G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
ENSUAMP00000005111Aldedh domain-containing protein. (208 aa)
ENSUAMP00000005311Uncharacterized protein. (1199 aa)
TNNI1Troponin I1, slow skeletal type. (185 aa)
ENSUAMP00000005686MSC domain-containing protein. (201 aa)
ENSUAMP00000005691LEM domain-containing protein. (179 aa)
PARVAParvin alpha. (286 aa)
ENSUAMP00000006083Dynein assembly factor 1, axonemal. (316 aa)
MKS1MKS transition zone complex subunit 1. (689 aa)
MESP2Mesoderm posterior bHLH transcription factor 2. (376 aa)
ENSUAMP00000007313Uncharacterized protein. (67 aa)
ENSUAMP00000007316BMERB domain-containing protein. (677 aa)
MICAL2Microtubule associated monooxygenase, calponin and LIM domain containing 2. (1103 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (158 aa)
ENSUAMP00000007554Uncharacterized protein. (354 aa)
FOXH1Forkhead box H1. (370 aa)
PTCH1Patched 1. (1453 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
TEAD2TEA domain transcription factor 2. (447 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
PTCD2Pentatricopeptide repeat domain 2. (427 aa)
GATA4GATA binding protein 4. (443 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (927 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
SOX4Transcription factor SOX. (452 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
TBX19T-box transcription factor 19. (444 aa)
NODALNodal growth differentiation factor. (348 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
ENSUAMP00000010093SUFU_C domain-containing protein. (81 aa)
ENSUAMP00000010224PH domain-containing protein. (66 aa)
TGFBR3Transforming growth factor beta receptor 3. (808 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
ENSUAMP00000010858Myosin_tail_1 domain-containing protein. (890 aa)
ENSUAMP00000010867Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (207 aa)
ENSUAMP00000010997TPR_REGION domain-containing protein. (150 aa)
ENSUAMP00000011008Uncharacterized protein. (538 aa)
TCAPTitin-cap. (167 aa)
ADPRHADP-ribosylarginine hydrolase. (362 aa)
ENSUAMP00000012276B30.2/SPRY domain-containing protein. (334 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
MEGF8Multiple EGF like domains 8. (2820 aa)
ENSUAMP00000013328Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (237 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
ENSUAMP00000015215Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
ENSUAMP00000015361CUB domain-containing protein. (131 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
FOXF1Forkhead box F1. (379 aa)
ARID2AT-rich interaction domain 2. (1776 aa)
CPECarboxypeptidase E. (338 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
ENSUAMP00000017162Uncharacterized protein. (137 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
MIB1Mindbomb E3 ubiquitin protein ligase 1. (1041 aa)
ENSUAMP00000017830Uncharacterized protein. (157 aa)
ADAM15ADAM metallopeptidase domain 15. (832 aa)
FLRT2Fibronectin leucine rich transmembrane protein 2. (660 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
NIPBLNipped-B protein. (1833 aa)
ENSUAMP00000018820Uncharacterized protein. (802 aa)
GATA5GATA binding protein 5. (414 aa)
MYBPC3Myosin binding protein C, cardiac. (1245 aa)
SYNPO2LSynaptopodin 2 like. (970 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1193 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
SRFSerum response factor. (507 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
ENSUAMP00000020431Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (76 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (851 aa)
HAS2Hyaluronan synthase 2. (541 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
NPY5RNeuropeptide Y receptor Y5. (446 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
C2CD3C2 domain containing 3 centriole elongation regulator. (2209 aa)
INSRTyrosine-protein kinase receptor. (1072 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
CCN1Cellular communication network factor 1. (382 aa)
ENSUAMP00000024427Recep_L_domain domain-containing protein. (297 aa)
LRP2LDL receptor related protein 2. (4684 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
RTN4Reticulon. (951 aa)
XIRP2Xin actin binding repeat containing 2. (3766 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
ENSUAMP00000025477Uncharacterized protein. (185 aa)
TBX20T-box transcription factor 20. (448 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (799 aa)
SOX9SRY-box transcription factor 9. (484 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD6Mothers against decapentaplegic homolog. (484 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (290 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (419 aa)
ENSUAMP00000028668Uncharacterized protein. (138 aa)
GATA3GATA binding protein 3. (444 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (757 aa)
TBXTT-box transcription factor T. (435 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (897 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
SLIT3Slit guidance ligand 3. (1441 aa)
ZIC3Uncharacterized protein. (466 aa)
ENGEndoglin. (650 aa)
ENSUAMP00000030304HH_signal domain-containing protein. (146 aa)
EDN1Endothelin 1. (202 aa)
ENSUAMP00000030480HARE-HTH domain-containing protein. (88 aa)
CCM2LCCM2 like scaffold protein. (466 aa)
MYLK2Myosin light chain kinase 2. (615 aa)
ASXL1ASXL transcriptional regulator 1. (1306 aa)
MYL2Myosin light chain 2. (192 aa)
LBX1Ladybird homeobox 1. (281 aa)
TBX6T-box transcription factor 6. (436 aa)
TMEM100Transmembrane protein 100. (134 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (630 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
AHI1Abelson helper integration site 1. (1054 aa)
ILKIntegrin linked kinase. (503 aa)
NOTCH2Notch receptor 2. (2374 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2987 aa)
FHL2Four and a half LIM domains 2. (279 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
ARL13BADP ribosylation factor like GTPase 13B. (430 aa)
NOTCH1Notch receptor 1. (2547 aa)
CLUAP1Clusterin associated protein 1. (442 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
IFT52Intraflagellar transport 52. (467 aa)
SNAI1Snail family transcriptional repressor 1. (259 aa)
MYL10Myosin light chain 10. (215 aa)
ENSUAMP00000035960Uncharacterized protein. (707 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ENSUAMP00000036217Uncharacterized protein. (186 aa)
GAAGlucosidase alpha, acid; Belongs to the glycosyl hydrolase 31 family. (952 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
SOX17SRY-box transcription factor 17. (406 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
KDM6ALysine demethylase 6A. (1381 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1044 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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