16 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NRP2	Neuropilin; Belongs to the neuropilin family. (851 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	ENG	Endoglin. (650 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SMAD6	Mothers against decapentaplegic homolog. (484 aa)
	TBX20	T-box transcription factor 20. (448 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (750 aa)
	LRP2	LDL receptor related protein 2. (4684 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1193 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	ENSUAMP00000015361	CUB domain-containing protein. (131 aa)
	ENSUAMP00000007313	Uncharacterized protein. (67 aa)
	PARVA	Parvin alpha. (286 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	TBX2	T-box transcription factor 2. (697 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMPR1A	ENSUAMP00000028868	ENSUAMP00000036181	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	BMPR2	ENSUAMP00000028868	ENSUAMP00000036920	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.990
BMP4	NKX2-5	ENSUAMP00000028868	ENSUAMP00000003298	Bone morphogenetic protein 4.	NK2 homeobox 5.	0.452
BMP4	SMAD4	ENSUAMP00000028868	ENSUAMP00000018392	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.888
BMP4	SMAD6	ENSUAMP00000028868	ENSUAMP00000026564	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.741
BMPR1A	BMP4	ENSUAMP00000036181	ENSUAMP00000028868	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.997
BMPR1A	BMPR2	ENSUAMP00000036181	ENSUAMP00000036920	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.977
BMPR1A	ENG	ENSUAMP00000036181	ENSUAMP00000030016	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.403
BMPR1A	SMAD4	ENSUAMP00000036181	ENSUAMP00000018392	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.847
BMPR1A	SMAD6	ENSUAMP00000036181	ENSUAMP00000026564	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.836
BMPR2	BMP4	ENSUAMP00000036920	ENSUAMP00000028868	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.990
BMPR2	BMPR1A	ENSUAMP00000036920	ENSUAMP00000036181	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.977
BMPR2	ENG	ENSUAMP00000036920	ENSUAMP00000030016	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.515
BMPR2	SMAD4	ENSUAMP00000036920	ENSUAMP00000018392	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.821
BMPR2	SMAD6	ENSUAMP00000036920	ENSUAMP00000026564	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.767
ENG	BMPR1A	ENSUAMP00000030016	ENSUAMP00000036181	Endoglin.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.403
ENG	BMPR2	ENSUAMP00000030016	ENSUAMP00000036920	Endoglin.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.515
ENSUAMP00000015361	SEMA3C	ENSUAMP00000015361	ENSUAMP00000025421	CUB domain-containing protein.	Semaphorin 3C; Belongs to the semaphorin family.	0.713
NKX2-5	BMP4	ENSUAMP00000003298	ENSUAMP00000028868	NK2 homeobox 5.	Bone morphogenetic protein 4.	0.452
NKX2-5	TBX2	ENSUAMP00000003298	ENSUAMP00000001331	NK2 homeobox 5.	T-box transcription factor 2.	0.667