(47 nodes) Outflow tract morphogenesis network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	SOX17	SRY-box transcription factor 17. (406 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	ENSUAMP00000003003	Plexin_cytopl domain-containing protein. (490 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	ENSUAMP00000004725	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
	ENSUAMP00000004728	G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
	PARVA	Parvin alpha. (286 aa)
	ENSUAMP00000007313	Uncharacterized protein. (67 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	FOXH1	Forkhead box H1. (370 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (927 aa)
	HES1	Hes family bHLH transcription factor 1. (259 aa)
	ATF2	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
	ENSUAMP00000015361	CUB domain-containing protein. (131 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	DVL2	Dishevelled segment polarity protein 2. (731 aa)
	NIPBL	Nipped-B protein. (1833 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1193 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
	TBX2	T-box transcription factor 2. (697 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	ENSUAMP00000020431	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (76 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (851 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	NPY5R	Neuropeptide Y receptor Y5. (446 aa)
	NPY1R	Neuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	LRP2	LDL receptor related protein 2. (4684 aa)
	DHRS3	Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (750 aa)
	TBX20	T-box transcription factor 20. (448 aa)
	SMAD6	Mothers against decapentaplegic homolog. (484 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	MEF2C	Myocyte enhancer factor 2C. (483 aa)
	ENG	Endoglin. (650 aa)
	EDN1	Endothelin 1. (202 aa)
	ILK	Integrin linked kinase. (503 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (823 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF2	JUN	ENSUAMP00000010037	ENSUAMP00000009019	Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.994
BMP4	BMPR1A	ENSUAMP00000028868	ENSUAMP00000036181	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	BMPR2	ENSUAMP00000028868	ENSUAMP00000036920	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.990
BMP4	ENSUAMP00000000600	ENSUAMP00000028868	ENSUAMP00000000600	Bone morphogenetic protein 4.	Uncharacterized protein.	0.428
BMP4	ENSUAMP00000017830	ENSUAMP00000028868	ENSUAMP00000017830	Bone morphogenetic protein 4.	Uncharacterized protein.	0.428
BMP4	FOXH1	ENSUAMP00000028868	ENSUAMP00000007591	Bone morphogenetic protein 4.	Forkhead box H1.	0.404
BMP4	HAND2	ENSUAMP00000028868	ENSUAMP00000007457	Bone morphogenetic protein 4.	Heart and neural crest derivatives expressed 2.	0.505
BMP4	JAG1	ENSUAMP00000028868	ENSUAMP00000034607	Bone morphogenetic protein 4.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.656
BMP4	MEF2C	ENSUAMP00000028868	ENSUAMP00000029640	Bone morphogenetic protein 4.	Myocyte enhancer factor 2C.	0.418
BMP4	NKX2-5	ENSUAMP00000028868	ENSUAMP00000003298	Bone morphogenetic protein 4.	NK2 homeobox 5.	0.452
BMP4	NOG	ENSUAMP00000028868	ENSUAMP00000001684	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.996
BMP4	NOTCH1	ENSUAMP00000028868	ENSUAMP00000034225	Bone morphogenetic protein 4.	Notch receptor 1.	0.426
BMP4	SMAD4	ENSUAMP00000028868	ENSUAMP00000018392	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.888
BMP4	SMAD6	ENSUAMP00000028868	ENSUAMP00000026564	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.741
BMP4	SOX17	ENSUAMP00000028868	ENSUAMP00000036659	Bone morphogenetic protein 4.	SRY-box transcription factor 17.	0.757
BMP4	WNT11	ENSUAMP00000028868	ENSUAMP00000002348	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.442
BMPR1A	BMP4	ENSUAMP00000036181	ENSUAMP00000028868	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.997
BMPR1A	BMPR2	ENSUAMP00000036181	ENSUAMP00000036920	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.977
BMPR1A	ENG	ENSUAMP00000036181	ENSUAMP00000030016	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.403
BMPR1A	NOG	ENSUAMP00000036181	ENSUAMP00000001684	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.700