9 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TBX20	T-box transcription factor 20. (448 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	NOTCH2	Notch receptor 2. (2374 aa)
	STRA6	Stimulated by retinoic acid 6. (642 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SMAD6	Mothers against decapentaplegic homolog. (484 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	ENSUAMP00000003258	Uncharacterized protein. (246 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	JAG1	ENSUAMP00000028868	ENSUAMP00000034607	Bone morphogenetic protein 4.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.656
BMP4	NOTCH1	ENSUAMP00000028868	ENSUAMP00000034225	Bone morphogenetic protein 4.	Notch receptor 1.	0.426
BMP4	SMAD6	ENSUAMP00000028868	ENSUAMP00000026564	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.741
ENSUAMP00000003258	JAG1	ENSUAMP00000003258	ENSUAMP00000034607	Uncharacterized protein.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.970
ENSUAMP00000003258	NOTCH1	ENSUAMP00000003258	ENSUAMP00000034225	Uncharacterized protein.	Notch receptor 1.	0.898
JAG1	BMP4	ENSUAMP00000034607	ENSUAMP00000028868	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Bone morphogenetic protein 4.	0.656
JAG1	ENSUAMP00000003258	ENSUAMP00000034607	ENSUAMP00000003258	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Uncharacterized protein.	0.970
JAG1	NOTCH1	ENSUAMP00000034607	ENSUAMP00000034225	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1.	0.997
JAG1	NOTCH2	ENSUAMP00000034607	ENSUAMP00000033903	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.971
NOTCH1	BMP4	ENSUAMP00000034225	ENSUAMP00000028868	Notch receptor 1.	Bone morphogenetic protein 4.	0.426
NOTCH1	ENSUAMP00000003258	ENSUAMP00000034225	ENSUAMP00000003258	Notch receptor 1.	Uncharacterized protein.	0.898
NOTCH1	JAG1	ENSUAMP00000034225	ENSUAMP00000034607	Notch receptor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.997
NOTCH1	NOTCH2	ENSUAMP00000034225	ENSUAMP00000033903	Notch receptor 1.	Notch receptor 2.	0.901
NOTCH2	JAG1	ENSUAMP00000033903	ENSUAMP00000034607	Notch receptor 2.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.971
NOTCH2	NOTCH1	ENSUAMP00000033903	ENSUAMP00000034225	Notch receptor 2.	Notch receptor 1.	0.901
SMAD6	BMP4	ENSUAMP00000026564	ENSUAMP00000028868	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 4.	0.741