STRINGSTRING
NOG NOG PROX1 PROX1 TBX5 TBX5 ENSUAMP00000003258 ENSUAMP00000003258 NKX2-5 NKX2-5 NSD2 NSD2 GATA4 GATA4 WNT2 WNT2 ENSUAMP00000010013 ENSUAMP00000010013 BMP10 BMP10 DLL4 DLL4 GJA5 GJA5 BMP2 BMP2 CCN1 CCN1 TBX20 TBX20 SMO SMO ENSUAMP00000028668 ENSUAMP00000028668 ENG ENG SOS1 SOS1 NOTCH2 NOTCH2 NOTCH1 NOTCH1 ENSUAMP00000035960 ENSUAMP00000035960 BMPR2 BMPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PROX1Prospero homeobox 1. (737 aa)
TBX5T-box transcription factor 5. (517 aa)
ENSUAMP00000003258Uncharacterized protein. (246 aa)
NKX2-5NK2 homeobox 5. (323 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1344 aa)
GATA4GATA binding protein 4. (443 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
CCN1Cellular communication network factor 1. (382 aa)
TBX20T-box transcription factor 20. (448 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
ENSUAMP00000028668Uncharacterized protein. (138 aa)
ENGEndoglin. (650 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
NOTCH2Notch receptor 2. (2374 aa)
NOTCH1Notch receptor 1. (2547 aa)
ENSUAMP00000035960Uncharacterized protein. (707 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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