STRINGSTRING
PRPF38A PRPF38A ENSUAMP00000000623 ENSUAMP00000000623 LSM4 LSM4 LSM7 LSM7 ENSUAMP00000000999 ENSUAMP00000000999 ENSUAMP00000001028 ENSUAMP00000001028 EFTUD2 EFTUD2 ENSUAMP00000001968 ENSUAMP00000001968 LUC7L LUC7L PRPF6 PRPF6 SYF2 SYF2 SNU13 SNU13 ENSUAMP00000004053 ENSUAMP00000004053 TXNL4A TXNL4A ZMAT2 ZMAT2 ENSUAMP00000005212 ENSUAMP00000005212 PRPF31 PRPF31 CWC25 CWC25 SF3A3 SF3A3 SF3A1 SF3A1 SF3B3 SF3B3 LSM8 LSM8 LSM8-2 LSM8-2 BUD31 BUD31 SNRPD2 SNRPD2 ENSUAMP00000010072 ENSUAMP00000010072 ENSUAMP00000010166 ENSUAMP00000010166 ENSUAMP00000010169 ENSUAMP00000010169 ENSUAMP00000011444 ENSUAMP00000011444 PRPF3 PRPF3 LUC7L3 LUC7L3 ENSUAMP00000011638 ENSUAMP00000011638 SNRPA1 SNRPA1 WBP4 WBP4 ENSUAMP00000012908 ENSUAMP00000012908 SNRPD3 SNRPD3 CWC22 CWC22 PRPF19 PRPF19 HTATSF1 HTATSF1 ENSUAMP00000016259 ENSUAMP00000016259 SNRPD1 SNRPD1 CWC27 CWC27 PLRG1 PLRG1 SNIP1 SNIP1 SNRPC SNRPC CASC3 CASC3 CCDC130 CCDC130 ENSUAMP00000019788 ENSUAMP00000019788 SNRNP70 SNRNP70 TFIP11 TFIP11 SNRPN SNRPN ENSUAMP00000020708 ENSUAMP00000020708 ENSUAMP00000020803 ENSUAMP00000020803 ENSUAMP00000021056 ENSUAMP00000021056 AQR AQR LSM3 LSM3 ENSUAMP00000021996 ENSUAMP00000021996 ENSUAMP00000021998 ENSUAMP00000021998 SRRM2 SRRM2 SNRNP40 SNRNP40 SNRPB2 SNRPB2 PRPF4 PRPF4 DHX8 DHX8 CRNKL1 CRNKL1 ENSUAMP00000024269 ENSUAMP00000024269 SF3B1 SF3B1 XAB2 XAB2 YJU2 YJU2 U2AF2 U2AF2 BUD13 BUD13 FMC1-LUC7L2 FMC1-LUC7L2 ENSUAMP00000026187 ENSUAMP00000026187 DHX15 DHX15 SF3B2 SF3B2 SART1 SART1 ENSUAMP00000026961 ENSUAMP00000026961 BCAS2 BCAS2 CDC40 CDC40 RBM8A RBM8A SNW1 SNW1 SNRPD2-2 SNRPD2-2 PHF5A PHF5A SNRPD2-3 SNRPD2-3 RNF113A RNF113A RBM22 RBM22 MFAP1 MFAP1 ENSUAMP00000033230 ENSUAMP00000033230 PRPF39 PRPF39 CCDC12 CCDC12 SMU1 SMU1 ENSUAMP00000033911 ENSUAMP00000033911 DHX16 DHX16 SF3B5 SF3B5 EIF4A3 EIF4A3 ENSUAMP00000037248 ENSUAMP00000037248 CDC5L CDC5L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRPF38APre-mRNA processing factor 38A. (312 aa)
ENSUAMP00000000623Uncharacterized protein. (86 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (139 aa)
LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (120 aa)
ENSUAMP00000000999RRM domain-containing protein. (126 aa)
ENSUAMP00000001028SF3A2 domain-containing protein. (192 aa)
EFTUD2Elongation factor Tu GTP binding domain containing 2. (970 aa)
ENSUAMP00000001968SFM domain-containing protein. (335 aa)
LUC7LLUC7 like. (364 aa)
PRPF6Pre-mRNA processing factor 6. (758 aa)
SYF2SYF2 pre-mRNA splicing factor. (246 aa)
SNU13Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa)
ENSUAMP00000004053Uncharacterized protein. (104 aa)
TXNL4AThioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (188 aa)
ZMAT2Zinc finger matrin-type 2. (192 aa)
ENSUAMP00000005212RED_C domain-containing protein. (188 aa)
PRPF31Pre-mRNA processing factor 31. (499 aa)
CWC25CWC25 spliceosome associated protein homolog. (425 aa)
SF3A3Splicing factor 3a subunit 3. (501 aa)
SF3A1Splicing factor 3a subunit 1. (795 aa)
SF3B3Splicing factor 3b subunit 3. (1217 aa)
LSM8U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (92 aa)
LSM8-2U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa)
BUD31BUD31 homolog. (144 aa)
SNRPD2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (53 aa)
ENSUAMP00000010072Sm domain-containing protein. (105 aa)
ENSUAMP00000010166SEC63 domain-containing protein. (329 aa)
ENSUAMP00000010169Uncharacterized protein. (1045 aa)
ENSUAMP00000011444PWI domain-containing protein. (112 aa)
PRPF3Pre-mRNA processing factor 3. (548 aa)
LUC7L3LUC7 like 3 pre-mRNA splicing factor. (413 aa)
ENSUAMP00000011638Uncharacterized protein. (80 aa)
SNRPA1Small nuclear ribonucleoprotein polypeptide A. (257 aa)
WBP4WW domain binding protein 4. (373 aa)
ENSUAMP00000012908GCFC domain-containing protein. (343 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
CWC22CWC22 spliceosome associated protein homolog. (910 aa)
PRPF19Pre-mRNA processing factor 19. (504 aa)
HTATSF1HIV-1 Tat specific factor 1. (750 aa)
ENSUAMP00000016259Uncharacterized protein. (194 aa)
SNRPD1Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (117 aa)
CWC27CWC27 spliceosome associated cyclophilin. (340 aa)
PLRG1Pleiotropic regulator 1. (503 aa)
SNIP1Smad nuclear interacting protein 1. (392 aa)
SNRPCU1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (148 aa)
CASC3CASC3 exon junction complex subunit. (704 aa)
CCDC130Coiled-coil domain containing 130. (392 aa)
ENSUAMP00000019788Uncharacterized protein. (1338 aa)
SNRNP70Small nuclear ribonucleoprotein U1 subunit 70. (438 aa)
TFIP11Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (777 aa)
SNRPNSmall nuclear ribonucleoprotein polypeptide N. (287 aa)
ENSUAMP00000020708Sm domain-containing protein. (74 aa)
ENSUAMP00000020803Uncharacterized protein. (278 aa)
ENSUAMP00000021056Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
AQRRNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1479 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (114 aa)
ENSUAMP00000021996Uncharacterized protein. (126 aa)
ENSUAMP00000021998Uncharacterized protein. (380 aa)
SRRM2Serine/arginine repetitive matrix 2. (2862 aa)
SNRNP40Small nuclear ribonucleoprotein U5 subunit 40. (358 aa)
SNRPB2Small nuclear ribonucleoprotein polypeptide B2. (224 aa)
PRPF4Pre-mRNA processing factor 4. (369 aa)
DHX8DEAH-box helicase 8. (1218 aa)
CRNKL1Crooked neck pre-mRNA splicing factor 1. (687 aa)
ENSUAMP00000024269Uncharacterized protein. (113 aa)
SF3B1Splicing factor 3b subunit 1. (1122 aa)
XAB2XPA binding protein 2. (855 aa)
YJU2YJU2 splicing factor homolog. (298 aa)
U2AF2U2 snRNP auxiliary factor large subunit; Necessary for the splicing of pre-mRNA. Belongs to the splicing factor SR family. (455 aa)
BUD13BUD13 homolog. (657 aa)
FMC1-LUC7L2FMC1-LUC7L2 readthrough. (392 aa)
ENSUAMP00000026187Sm domain-containing protein. (72 aa)
DHX15DEAH-box helicase 15. (728 aa)
SF3B2Splicing factor 3b subunit 2. (910 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (765 aa)
ENSUAMP00000026961Uncharacterized protein. (113 aa)
BCAS2BCAS2 pre-mRNA processing factor. (203 aa)
CDC40Cell division cycle 40. (318 aa)
RBM8ARNA-binding protein 8A; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. (174 aa)
SNW1SNW domain containing 1. (511 aa)
SNRPD2-2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (123 aa)
PHF5APHD finger protein 5A. (85 aa)
SNRPD2-3Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
RNF113ARing finger protein 113A. (340 aa)
RBM22RNA binding motif protein 22. (420 aa)
MFAP1Microfibril associated protein 1. (439 aa)
ENSUAMP00000033230RRM domain-containing protein. (125 aa)
PRPF39Pre-mRNA processing factor 39. (667 aa)
CCDC12Coiled-coil domain containing 12. (175 aa)
SMU1SMU1 DNA replication regulator and spliceosomal factor. (513 aa)
ENSUAMP00000033911Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
DHX16DEAH-box helicase 16. (1041 aa)
SF3B5Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
EIF4A3Eukaryotic translation initiation factor 4A3; Belongs to the DEAD box helicase family. (411 aa)
ENSUAMP00000037248MPN domain-containing protein. (979 aa)
CDC5LCell division cycle 5 like. (544 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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