STRINGSTRING
CRB2 CRB2 VTN VTN HAND1 HAND1 LRP5 LRP5 ENSUAMP00000025721 ENSUAMP00000025721 LMBRD1 LMBRD1 SMAD3 SMAD3 ENSUAMP00000026772 ENSUAMP00000026772 ENSUAMP00000026773 ENSUAMP00000026773 RNF2 RNF2 CTR9 CTR9 TLX2 TLX2 COL8A1 COL8A1 UGDH UGDH ITGB5 ITGB5 ENSUAMP00000000756 ENSUAMP00000000756 TP53 TP53 ENSUAMP00000001212 ENSUAMP00000001212 NOG NOG MSGN1 MSGN1 WNT11 WNT11 SYF2 SYF2 ENSUAMP00000003531 ENSUAMP00000003531 DUSP1 DUSP1 ITGB4 ITGB4 SFRP1 SFRP1 ENSUAMP00000004596 ENSUAMP00000004596 TWSG1 TWSG1 ENSUAMP00000006064 ENSUAMP00000006064 ENSUAMP00000010997 ENSUAMP00000010997 TENM4 TENM4 ENSUAMP00000010461 ENSUAMP00000010461 OTX2 OTX2 ENSUAMP00000010104 ENSUAMP00000010104 ITGB1 ITGB1 NODAL NODAL TBX19 TBX19 KDM6A KDM6A ENSUAMP00000037141 ENSUAMP00000037141 LDB1 LDB1 BMPR2 BMPR2 EOMES EOMES SOX17 SOX17 LHX1 LHX1 BMPR1A BMPR1A WNT3 WNT3 ENSUAMP00000035777 ENSUAMP00000035777 ITGA2 ITGA2 SNAI1 SNAI1 TASOR TASOR FRS2 FRS2 POGLUT1 POGLUT1 TAF10 TAF10 PRKAR1A PRKAR1A SETD2 SETD2 AMOT AMOT FN1 FN1 COL12A1 COL12A1 TBX6 TBX6 RTF1 RTF1 ITGAV ITGAV ZIC3 ZIC3 CER1 CER1 NR0B1 NR0B1 MMP14 MMP14 HNF1A HNF1A TBXT TBXT ENSUAMP00000006350 ENSUAMP00000006350 MESP2 MESP2 EXT2 EXT2 INHBA INHBA BMP4 BMP4 ITGA5 ITGA5 ENSUAMP00000007522 ENSUAMP00000007522 PRKAR1B PRKAR1B ATOH8 ATOH8 APLNR APLNR ENSUAMP00000014216 ENSUAMP00000014216 ENSUAMP00000013897 ENSUAMP00000013897 MEGF8 MEGF8 EXT1 EXT1 ENSUAMP00000013092 ENSUAMP00000013092 GRB2 GRB2 ENSUAMP00000012642 ENSUAMP00000012642 WNT3A WNT3A PAF1 PAF1 ENSUAMP00000012266 ENSUAMP00000012266 ENSUAMP00000011840 ENSUAMP00000011840 ENSUAMP00000011833 ENSUAMP00000011833 COL4A2 COL4A2 ITGA8 ITGA8 ARFRP1 ARFRP1 ENSUAMP00000011100 ENSUAMP00000011100 ENSUAMP00000011008 ENSUAMP00000011008 CUL3 CUL3 DVL1 DVL1 ENSUAMP00000016192 ENSUAMP00000016192 FOXF1 FOXF1 DUSP4 DUSP4 ENSUAMP00000017162 ENSUAMP00000017162 RIC8A RIC8A ARMC5 ARMC5 APLN APLN HOXA11 HOXA11 ITGA3 ITGA3 SMAD4 SMAD4 EPHA2 EPHA2 DVL2 DVL2 LEO1 LEO1 ITGA7 ITGA7 ENSUAMP00000019295 ENSUAMP00000019295 NF2 NF2 AXIN1 AXIN1 SRF SRF RACK1 RACK1 EYA1 EYA1 ENSUAMP00000020431 ENSUAMP00000020431 LAMB3 LAMB3 MMP8 MMP8 DUSP5 DUSP5 MMP15 MMP15 GPI GPI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRB2Crumbs cell polarity complex component 2. (1280 aa)
VTNSMB domain-containing protein. (415 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
ENSUAMP00000025721Uncharacterized protein. (113 aa)
LMBRD1LMBR1 domain containing 1. (398 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ENSUAMP00000026772ETS domain-containing protein. (163 aa)
ENSUAMP00000026773Uncharacterized protein. (179 aa)
RNF2Ring finger protein 2. (336 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
TLX2T cell leukemia homeobox 2. (284 aa)
COL8A1Collagen type VIII alpha 1 chain. (744 aa)
UGDHUDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (494 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (621 aa)
ENSUAMP00000000756MH1 domain-containing protein. (170 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ENSUAMP00000001212Uncharacterized protein. (168 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MSGN1Mesogenin 1. (187 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SYF2SYF2 pre-mRNA splicing factor. (246 aa)
ENSUAMP00000003531BTB domain-containing protein. (67 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
ITGB4Integrin subunit beta 4. (1096 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
ENSUAMP00000004596Uncharacterized protein. (196 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (202 aa)
ENSUAMP00000006064Uncharacterized protein. (80 aa)
ENSUAMP00000010997TPR_REGION domain-containing protein. (150 aa)
TENM4Teneurin transmembrane protein 4. (2640 aa)
ENSUAMP00000010461BHLH domain-containing protein. (178 aa)
OTX2Orthodenticle homeobox 2. (297 aa)
ENSUAMP00000010104acidPPc domain-containing protein. (312 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (771 aa)
NODALNodal growth differentiation factor. (348 aa)
TBX19T-box transcription factor 19. (444 aa)
KDM6ALysine demethylase 6A. (1381 aa)
ENSUAMP00000037141Uncharacterized protein. (54 aa)
LDB1LIM domain binding 1. (411 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
EOMESEomesodermin. (687 aa)
SOX17SRY-box transcription factor 17. (406 aa)
LHX1LIM homeobox 1. (406 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1121 aa)
SNAI1Snail family transcriptional repressor 1. (259 aa)
TASORTranscription activation suppressor. (1518 aa)
FRS2Fibroblast growth factor receptor substrate 2. (507 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (199 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2520 aa)
AMOTAngiomotin. (1058 aa)
FN1Fibronectin 1. (2385 aa)
COL12A1Collagen type XII alpha 1 chain. (3031 aa)
TBX6T-box transcription factor 6. (436 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (424 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
ZIC3Uncharacterized protein. (466 aa)
CER1Cerberus 1, DAN family BMP antagonist. (279 aa)
NR0B1Nuclear receptor subfamily 0 group B member 1. (471 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
HNF1AHNF1 homeobox A. (631 aa)
TBXTT-box transcription factor T. (435 aa)
ENSUAMP00000006350Uncharacterized protein. (85 aa)
MESP2Mesoderm posterior bHLH transcription factor 2. (376 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (673 aa)
INHBAInhibin subunit beta A. (424 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1067 aa)
ENSUAMP00000007522VWFA domain-containing protein. (246 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (377 aa)
ATOH8Atonal bHLH transcription factor 8. (322 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
ENSUAMP00000014216Homeobox domain-containing protein. (315 aa)
ENSUAMP00000013897Uncharacterized protein. (165 aa)
MEGF8Multiple EGF like domains 8. (2820 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
ENSUAMP00000013092Uncharacterized protein. (1105 aa)
GRB2Growth factor receptor bound protein 2. (203 aa)
ENSUAMP00000012642Integrin_alpha2 domain-containing protein. (261 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (528 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
ENSUAMP00000011840BTB domain-containing protein. (208 aa)
ENSUAMP00000011833C2H2-type domain-containing protein. (81 aa)
COL4A2Collagen type IV alpha 2 chain. (1617 aa)
ITGA8Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (901 aa)
ARFRP1ADP ribosylation factor related protein 1. (193 aa)
ENSUAMP00000011100Uncharacterized protein. (508 aa)
ENSUAMP00000011008Uncharacterized protein. (538 aa)
CUL3Cullin 3; Belongs to the cullin family. (766 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
ENSUAMP00000016192Integrin beta; Belongs to the integrin beta chain family. (786 aa)
FOXF1Forkhead box F1. (379 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (393 aa)
ENSUAMP00000017162Uncharacterized protein. (137 aa)
RIC8ARIC8 guanine nucleotide exchange factor A. (616 aa)
ARMC5Armadillo repeat containing 5. (943 aa)
APLNApelin. (71 aa)
HOXA11Homeobox A11. (313 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1051 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
EPHA2EPH receptor A2. (966 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (618 aa)
ITGA7Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
ENSUAMP00000019295Uncharacterized protein. (386 aa)
NF2Neurofibromin 2. (596 aa)
AXIN1Axin 1. (867 aa)
SRFSerum response factor. (507 aa)
RACK1Receptor for activated C kinase 1. (374 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
ENSUAMP00000020431Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (76 aa)
LAMB3Laminin subunit beta 3. (1172 aa)
MMP8Matrix metallopeptidase 8. (477 aa)
DUSP5Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
MMP15Matrix metallopeptidase 15. (640 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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