52 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000037141	Uncharacterized protein. (54 aa)
	ENSUAMP00000000130	Bromo domain-containing protein. (70 aa)
	ITGB5	Integrin beta; Belongs to the integrin beta chain family. (621 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	PELO	Protein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
	DUSP1	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
	PAX9	Paired box 9. (342 aa)
	INHBA	Inhibin subunit beta A. (424 aa)
	ENSUAMP00000007522	VWFA domain-containing protein. (246 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	COL4A2	Collagen type IV alpha 2 chain. (1617 aa)
	PAF1	PAF1 homolog, Paf1/RNA polymerase II complex component. (528 aa)
	ARC	Activity regulated cytoskeleton associated protein. (396 aa)
	ENSUAMP00000012642	Integrin_alpha2 domain-containing protein. (261 aa)
	GRB2	Growth factor receptor bound protein 2. (203 aa)
	ENSUAMP00000013092	Uncharacterized protein. (1105 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	ENSUAMP00000013897	Uncharacterized protein. (165 aa)
	DUSP4	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (393 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	LEO1	LEO1 homolog, Paf1/RNA polymerase II complex component. (618 aa)
	ITGA7	Integrin subunit alpha 7; Belongs to the integrin alpha chain family. (1181 aa)
	ENSUAMP00000019295	Uncharacterized protein. (386 aa)
	LAMB3	Laminin subunit beta 3. (1172 aa)
	MMP8	Matrix metallopeptidase 8. (477 aa)
	DUSP5	Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (382 aa)
	MMP15	Matrix metallopeptidase 15. (640 aa)
	VTN	SMB domain-containing protein. (415 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
	ENSUAMP00000025721	Uncharacterized protein. (113 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	CTR9	CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
	COL8A1	Collagen type VIII alpha 1 chain. (744 aa)
	ITGA5	Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1067 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	MMP14	Matrix metallopeptidase 14. (582 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (471 aa)
	ITGAV	Integrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
	RTF1	RTF1 homolog, Paf1/RNA polymerase II complex component. (424 aa)
	NKX2-1	NK2 homeobox 1. (370 aa)
	COL12A1	Collagen type XII alpha 1 chain. (3031 aa)
	FN1	Fibronectin 1. (2385 aa)
	NKX2-2	NK2 homeobox 2. (273 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2520 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	BPTF	Bromodomain PHD finger transcription factor. (2478 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	LHX1	LIM homeobox 1. (406 aa)
	SOX17	SRY-box transcription factor 17. (406 aa)
	EOMES	Eomesodermin. (687 aa)
	LDB1	LIM domain binding 1. (411 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	BMPR1A	ENSUAMP00000028868	ENSUAMP00000036181	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	COL8A1	ENSUAMP00000028868	ENSUAMP00000028191	Bone morphogenetic protein 4.	Collagen type VIII alpha 1 chain.	0.501
BMP4	EOMES	ENSUAMP00000028868	ENSUAMP00000036778	Bone morphogenetic protein 4.	Eomesodermin.	0.534
BMP4	NOG	ENSUAMP00000028868	ENSUAMP00000001684	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.996
BMP4	NOTCH1	ENSUAMP00000028868	ENSUAMP00000034225	Bone morphogenetic protein 4.	Notch receptor 1.	0.426
BMP4	PAX9	ENSUAMP00000028868	ENSUAMP00000003891	Bone morphogenetic protein 4.	Paired box 9.	0.457
BMP4	SMAD3	ENSUAMP00000028868	ENSUAMP00000026563	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.697
BMP4	SMAD4	ENSUAMP00000028868	ENSUAMP00000018392	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.888
BMP4	SOX17	ENSUAMP00000028868	ENSUAMP00000036659	Bone morphogenetic protein 4.	SRY-box transcription factor 17.	0.757
BMP4	VTN	ENSUAMP00000028868	ENSUAMP00000023550	Bone morphogenetic protein 4.	SMB domain-containing protein.	0.457
BMPR1A	BMP4	ENSUAMP00000036181	ENSUAMP00000028868	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.997
BMPR1A	INHBA	ENSUAMP00000036181	ENSUAMP00000007348	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Inhibin subunit beta A.	0.534
BMPR1A	NODAL	ENSUAMP00000036181	ENSUAMP00000009938	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Nodal growth differentiation factor.	0.486
BMPR1A	NOG	ENSUAMP00000036181	ENSUAMP00000001684	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.700
BMPR1A	SMAD3	ENSUAMP00000036181	ENSUAMP00000026563	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.971
BMPR1A	SMAD4	ENSUAMP00000036181	ENSUAMP00000018392	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.847
BPTF	ENSUAMP00000000130	ENSUAMP00000035740	ENSUAMP00000000130	Bromodomain PHD finger transcription factor.	Bromo domain-containing protein.	0.931
BPTF	SETD2	ENSUAMP00000035740	ENSUAMP00000033518	Bromodomain PHD finger transcription factor.	SET domain containing 2, histone lysine methyltransferase.	0.764
COL12A1	COL4A2	ENSUAMP00000032073	ENSUAMP00000011825	Collagen type XII alpha 1 chain.	Collagen type IV alpha 2 chain.	0.755
COL12A1	COL8A1	ENSUAMP00000032073	ENSUAMP00000028191	Collagen type XII alpha 1 chain.	Collagen type VIII alpha 1 chain.	0.414