81 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TLX2	T cell leukemia homeobox 2. (284 aa)
	ENSUAMP00000025477	Uncharacterized protein. (185 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (218 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	CRB2	Crumbs cell polarity complex component 2. (1280 aa)
	LHX2	LIM homeobox 2. (392 aa)
	GPI	Glucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
	ENSUAMP00000020431	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (76 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
	SRF	Serum response factor. (507 aa)
	AXIN1	Axin 1. (867 aa)
	NF2	Neurofibromin 2. (596 aa)
	CTDNEP1	CTD nuclear envelope phosphatase 1. (244 aa)
	EPHA2	EPH receptor A2. (966 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	ITGA3	Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1051 aa)
	HOXA11	Homeobox A11. (313 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	ARMC5	Armadillo repeat containing 5. (943 aa)
	ENSUAMP00000017162	Uncharacterized protein. (137 aa)
	FOXF1	Forkhead box F1. (379 aa)
	ENSUAMP00000016192	Integrin beta; Belongs to the integrin beta chain family. (786 aa)
	IRX3	Iroquois homeobox 3. (502 aa)
	ENSUAMP00000014637	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (331 aa)
	ENSUAMP00000014216	Homeobox domain-containing protein. (315 aa)
	ENSUAMP00000013820	Uncharacterized protein; Belongs to the nucleosome assembly protein (NAP) family. (313 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
	ENSUAMP00000012266	CTNNB1_binding domain-containing protein. (162 aa)
	ITGA8	Integrin subunit alpha 8; Belongs to the integrin alpha chain family. (901 aa)
	ENSUAMP00000011100	Uncharacterized protein. (508 aa)
	ENSUAMP00000010461	BHLH domain-containing protein. (178 aa)
	ITGB1	Integrin beta; Belongs to the integrin beta chain family. (771 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	TBX19	T-box transcription factor 19. (444 aa)
	TEAD2	TEA domain transcription factor 2. (447 aa)
	PRKAR1B	Protein kinase cAMP-dependent type I regulatory subunit beta. (377 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	FOXH1	Forkhead box H1. (370 aa)
	INHBA	Inhibin subunit beta A. (424 aa)
	EXT2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (673 aa)
	MESP2	Mesoderm posterior bHLH transcription factor 2. (376 aa)
	TWSG1	Twisted gastrulation BMP signaling modulator 1. (202 aa)
	ENSUAMP00000004596	Uncharacterized protein. (196 aa)
	ITGB4	Integrin subunit beta 4. (1096 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	MSGN1	Mesogenin 1. (187 aa)
	DLL3	Delta like canonical Notch ligand 3. (565 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	ENSUAMP00000001212	Uncharacterized protein. (168 aa)
	ENSUAMP00000000756	MH1 domain-containing protein. (170 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	SNAI1	Snail family transcriptional repressor 1. (259 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	POGLUT1	Protein O-glucosyltransferase 1. (392 aa)
	TAF10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (199 aa)
	PRKAR1A	Protein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2520 aa)
	TBX6	T-box transcription factor 6. (436 aa)
	ZIC3	Uncharacterized protein. (466 aa)
	HNF1A	HNF1 homeobox A. (631 aa)
	TBXT	T-box transcription factor T. (435 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
	OVOL1	Ovo like transcriptional repressor 1. (247 aa)
	ENSUAMP00000026773	Uncharacterized protein. (179 aa)
	ENSUAMP00000026772	ETS domain-containing protein. (163 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	ENSUAMP00000025721	Uncharacterized protein. (113 aa)
	ENSUAMP00000035777	HMG box domain-containing protein. (191 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	LHX1	LIM homeobox 1. (406 aa)
	SCX	Scleraxis bHLH transcription factor. (201 aa)
	EOMES	Eomesodermin. (687 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
	LDB1	LIM domain binding 1. (411 aa)
	ENSUAMP00000037141	Uncharacterized protein. (54 aa)
	KDM6A	Lysine demethylase 6A. (1381 aa)
	ITGA2	Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1121 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN1	ENSUAMP00000012266	ENSUAMP00000019889	ENSUAMP00000012266	Axin 1.	CTNNB1_binding domain-containing protein.	0.934
AXIN1	ENSUAMP00000035777	ENSUAMP00000019889	ENSUAMP00000035777	Axin 1.	HMG box domain-containing protein.	0.934
AXIN1	WNT3	ENSUAMP00000019889	ENSUAMP00000035954	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.634
AXIN1	WNT3A	ENSUAMP00000019889	ENSUAMP00000012363	Axin 1.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.634
BMP4	BMPR1A	ENSUAMP00000028868	ENSUAMP00000036181	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	BMPR2	ENSUAMP00000028868	ENSUAMP00000036920	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.990
BMP4	ENSUAMP00000000600	ENSUAMP00000028868	ENSUAMP00000000600	Bone morphogenetic protein 4.	Uncharacterized protein.	0.428
BMP4	ENSUAMP00000000756	ENSUAMP00000028868	ENSUAMP00000000756	Bone morphogenetic protein 4.	MH1 domain-containing protein.	0.695
BMP4	ENSUAMP00000012266	ENSUAMP00000028868	ENSUAMP00000012266	Bone morphogenetic protein 4.	CTNNB1_binding domain-containing protein.	0.525
BMP4	ENSUAMP00000014216	ENSUAMP00000028868	ENSUAMP00000014216	Bone morphogenetic protein 4.	Homeobox domain-containing protein.	0.759
BMP4	ENSUAMP00000017830	ENSUAMP00000028868	ENSUAMP00000017830	Bone morphogenetic protein 4.	Uncharacterized protein.	0.428
BMP4	ENSUAMP00000035777	ENSUAMP00000028868	ENSUAMP00000035777	Bone morphogenetic protein 4.	HMG box domain-containing protein.	0.525
BMP4	EOMES	ENSUAMP00000028868	ENSUAMP00000036778	Bone morphogenetic protein 4.	Eomesodermin.	0.534
BMP4	FOXF1	ENSUAMP00000028868	ENSUAMP00000016230	Bone morphogenetic protein 4.	Forkhead box F1.	0.500
BMP4	FOXH1	ENSUAMP00000028868	ENSUAMP00000007591	Bone morphogenetic protein 4.	Forkhead box H1.	0.404
BMP4	ITGB1	ENSUAMP00000028868	ENSUAMP00000009994	Bone morphogenetic protein 4.	Integrin beta; Belongs to the integrin beta chain family.	0.421
BMP4	NOG	ENSUAMP00000028868	ENSUAMP00000001684	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.996
BMP4	SMAD3	ENSUAMP00000028868	ENSUAMP00000026563	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.697
BMP4	SMAD4	ENSUAMP00000028868	ENSUAMP00000018392	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.888
BMP4	TBX19	ENSUAMP00000028868	ENSUAMP00000009515	Bone morphogenetic protein 4.	T-box transcription factor 19.	0.436