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HAAO HAAO NAMPT NAMPT ENSUAMP00000013982 ENSUAMP00000013982 IDO1 IDO1 NMRK1 NMRK1 NAPRT NAPRT MROH6 MROH6 ASPDH ASPDH JOSD2 JOSD2 KYNU KYNU NMNAT1 NMNAT1 KMO KMO NMNAT2 NMNAT2 NADSYN1 NADSYN1 ENSUAMP00000029039 ENSUAMP00000029039 ENSUAMP00000029041 ENSUAMP00000029041 QPRT QPRT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HAAO3-hydroxyanthranilate 3,4-dioxygenase. (264 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (505 aa)
ENSUAMP00000013982Uncharacterized protein. (305 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (386 aa)
NMRK1Nicotinamide riboside kinase 1. (202 aa)
NAPRTNicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (538 aa)
MROH6Maestro heat like repeat family member 6. (705 aa)
ASPDHAspartate dehydrogenase domain containing. (284 aa)
JOSD2Josephin domain containing 2. (188 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (422 aa)
NMNAT1Nicotinamide-nucleotide adenylyltransferase. (280 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (477 aa)
NMNAT2Nicotinamide nucleotide adenylyltransferase 2. (307 aa)
NADSYN1Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (723 aa)
ENSUAMP00000029039CTP_transf_like domain-containing protein. (180 aa)
ENSUAMP00000029041CTP_transf_like domain-containing protein. (61 aa)
QPRTQuinolinate phosphoribosyltransferase. (324 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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