STRINGSTRING
ENSUAMP00000000385 ENSUAMP00000000385 PGR PGR RXFP2 RXFP2 LATS2 LATS2 SLC27A1 SLC27A1 TRH TRH PPARG PPARG ENSUAMP00000002304 ENSUAMP00000002304 SSTR4 SSTR4 ENSUAMP00000002936 ENSUAMP00000002936 NR1H3 NR1H3 SSTR1 SSTR1 RARG RARG ENSUAMP00000004313 ENSUAMP00000004313 ENSUAMP00000004918 ENSUAMP00000004918 ESR1 ESR1 LATS1 LATS1 ENSUAMP00000006938 ENSUAMP00000006938 ASIP ASIP UCN3 UCN3 DDX17 DDX17 SSTR2 SSTR2 ENSUAMP00000009436 ENSUAMP00000009436 ENSUAMP00000009766 ENSUAMP00000009766 PTPN11 PTPN11 PPARA PPARA CALCOCO1 CALCOCO1 ENSUAMP00000012231 ENSUAMP00000012231 AR AR RARB RARB RBFOX2 RBFOX2 OSTN OSTN ENSUAMP00000015431 ENSUAMP00000015431 ENSUAMP00000015992 ENSUAMP00000015992 ENSUAMP00000016402 ENSUAMP00000016402 PPARD PPARD RARA RARA ESRRA ESRRA THRA THRA NR1D2 NR1D2 AGRP AGRP ENSUAMP00000020805 ENSUAMP00000020805 ENSUAMP00000020894 ENSUAMP00000020894 CRHR2 CRHR2 ADIPOR2 ADIPOR2 ENSUAMP00000023035 ENSUAMP00000023035 ADIPOR1 ADIPOR1 ESRRG ESRRG TMF1 TMF1 GHSR GHSR ESRRB ESRRB UCN2 UCN2 ACSL1 ACSL1 YWHAH YWHAH KDM3A KDM3A ENSUAMP00000025477 ENSUAMP00000025477 FSHR FSHR HNF4G HNF4G ENSUAMP00000026668 ENSUAMP00000026668 RXRA RXRA ENSUAMP00000027844 ENSUAMP00000027844 ENSUAMP00000027845 ENSUAMP00000027845 BMP4 BMP4 POU4F2 POU4F2 PRLR PRLR NR3C1 NR3C1 TRIP4 TRIP4 SRC SRC DDX5 DDX5 SSTR3 SSTR3 CST11 CST11 PADI2 PADI2 PHB PHB ENSUAMP00000032266 ENSUAMP00000032266 ENSUAMP00000032289 ENSUAMP00000032289 NR5A1 NR5A1 PAQR7 PAQR7 RXFP1 RXFP1 MED1 MED1 ARID1A ARID1A APPL2 APPL2 CRHBP CRHBP GPER1 GPER1 RXRB RXRB DAXX DAXX PHB2 PHB2 APPL1 APPL1 ZMIZ1 ZMIZ1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000000385Uncharacterized protein. (81 aa)
PGRProgesterone receptor. (634 aa)
RXFP2Relaxin family peptide receptor 2. (720 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
SLC27A1Solute carrier family 27 member 1. (646 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (242 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
ENSUAMP00000002304Uncharacterized protein. (93 aa)
SSTR4Somatostatin receptor 4; Belongs to the G-protein coupled receptor 1 family. (387 aa)
ENSUAMP00000002936Uncharacterized protein. (354 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
SSTR1Somatostatin receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
RARGRetinoic acid receptor gamma. (458 aa)
ENSUAMP00000004313Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (64 aa)
ENSUAMP00000004918Homeobox domain-containing protein. (230 aa)
ESR1Estrogen receptor 1. (490 aa)
LATS1Uncharacterized protein. (1012 aa)
ENSUAMP00000006938Uncharacterized protein. (133 aa)
ASIPAgouti signaling protein. (132 aa)
UCN3Urocortin 3. (168 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (715 aa)
SSTR2Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
ENSUAMP00000009436HECT domain-containing protein. (51 aa)
ENSUAMP00000009766Uncharacterized protein. (462 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
PPARAPeroxisome proliferator activated receptor alpha. (503 aa)
CALCOCO1Calcium binding and coiled-coil domain 1. (691 aa)
ENSUAMP00000012231Uncharacterized protein. (632 aa)
ARAndrogen receptor. (905 aa)
RARBRetinoic acid receptor beta. (336 aa)
RBFOX2RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (384 aa)
OSTNOsteocrin. (132 aa)
ENSUAMP00000015431Uncharacterized protein. (297 aa)
ENSUAMP00000015992G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (246 aa)
ENSUAMP00000016402Uncharacterized protein. (427 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
RARARetinoic acid receptor alpha. (462 aa)
ESRRAEstrogen related receptor alpha. (422 aa)
THRAThyroid hormone receptor alpha. (511 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (546 aa)
AGRPAgouti related neuropeptide. (131 aa)
ENSUAMP00000020805UBR-type domain-containing protein. (2331 aa)
ENSUAMP00000020894annotation not available (354 aa)
CRHR2Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. (418 aa)
ADIPOR2Adiponectin receptor 2. (386 aa)
ENSUAMP00000023035Uncharacterized protein. (527 aa)
ADIPOR1Adiponectin receptor 1. (375 aa)
ESRRGEstrogen related receptor gamma. (435 aa)
TMF1TATA element modulatory factor 1. (1089 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
ESRRBEstrogen related receptor beta. (454 aa)
UCN2Urocortin 2. (112 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (436 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
KDM3ALysine demethylase 3A. (1323 aa)
ENSUAMP00000025477Uncharacterized protein. (185 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (691 aa)
HNF4GHepatocyte nuclear factor 4 gamma. (408 aa)
ENSUAMP00000026668Uncharacterized protein. (112 aa)
RXRARetinoid X receptor alpha. (469 aa)
ENSUAMP00000027844Nuc_recep-AF1 domain-containing protein. (202 aa)
ENSUAMP00000027845Uncharacterized protein. (347 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
POU4F2POU domain protein. (408 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin. (625 aa)
NR3C1Nuclear receptor subfamily 3 group C member 1. (781 aa)
TRIP4Thyroid hormone receptor interactor 4. (348 aa)
SRCTyrosine-protein kinase. (557 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
SSTR3Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (414 aa)
CST11Cystatin 11. (137 aa)
PADI2Peptidyl arginine deiminase 2. (673 aa)
PHBProhibitin. (272 aa)
ENSUAMP00000032266RRM domain-containing protein. (778 aa)
ENSUAMP00000032289SAP domain-containing protein. (117 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
PAQR7Progestin and adipoQ receptor family member 7. (348 aa)
RXFP1Relaxin family peptide receptor 1. (724 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
ARID1AAT-rich interaction domain 1A. (1930 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (652 aa)
CRHBPCorticotropin releasing hormone binding protein. (315 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
RXRBRetinoid X receptor beta. (532 aa)
DAXXDeath domain associated protein. (756 aa)
PHB2Prohibitin. (297 aa)
APPL1Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1. (665 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1044 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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