19 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MSX1	Msh homeobox 1. (303 aa)
	PHF14	PHD finger protein 14. (843 aa)
	TBX2	T-box transcription factor 2. (697 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	ENSUAMP00000002679	Uncharacterized protein. (108 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	DCHS2	Dachsous cadherin-related 2. (3356 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (496 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1282 aa)
	SOX9	SRY-box transcription factor 9. (484 aa)
	SIX2	SIX homeobox 2. (296 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
	DCHS1	Dachsous cadherin-related 1. (3297 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	BMP4	ENSUAMP00000021596	ENSUAMP00000028868	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.943
BMP2	FGF4	ENSUAMP00000021596	ENSUAMP00000032522	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.537
BMP2	FGF7	ENSUAMP00000021596	ENSUAMP00000015433	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.534
BMP2	FGF9	ENSUAMP00000021596	ENSUAMP00000004863	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.535
BMP2	GPC3	ENSUAMP00000021596	ENSUAMP00000021714	Bone morphogenetic protein 2.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.429
BMP2	SOX9	ENSUAMP00000021596	ENSUAMP00000026554	Bone morphogenetic protein 2.	SRY-box transcription factor 9.	0.578
BMP4	BMP2	ENSUAMP00000028868	ENSUAMP00000021596	Bone morphogenetic protein 4.	Bone morphogenetic protein 2.	0.943
BMP4	FGF4	ENSUAMP00000028868	ENSUAMP00000032522	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.649
BMP4	FGF7	ENSUAMP00000028868	ENSUAMP00000015433	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.603
BMP4	FGF9	ENSUAMP00000028868	ENSUAMP00000004863	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.597
BMP4	GPC3	ENSUAMP00000028868	ENSUAMP00000021714	Bone morphogenetic protein 4.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.429
BMP4	HAND2	ENSUAMP00000028868	ENSUAMP00000007457	Bone morphogenetic protein 4.	Heart and neural crest derivatives expressed 2.	0.505
BMP4	KDR	ENSUAMP00000028868	ENSUAMP00000023136	Bone morphogenetic protein 4.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.491
BMP4	MSX1	ENSUAMP00000028868	ENSUAMP00000000613	Bone morphogenetic protein 4.	Msh homeobox 1.	0.628
BMP4	SOX9	ENSUAMP00000028868	ENSUAMP00000026554	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.606
BMP4	WNT11	ENSUAMP00000028868	ENSUAMP00000002348	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.442
DCHS1	DCHS2	ENSUAMP00000033793	ENSUAMP00000017596	Dachsous cadherin-related 1.	Dachsous cadherin-related 2.	0.944
DCHS2	DCHS1	ENSUAMP00000017596	ENSUAMP00000033793	Dachsous cadherin-related 2.	Dachsous cadherin-related 1.	0.944
ENSUAMP00000002679	WNT11	ENSUAMP00000002679	ENSUAMP00000002348	Uncharacterized protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.557
FGF4	BMP2	ENSUAMP00000032522	ENSUAMP00000021596	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 2.	0.537