STRINGSTRING
PLA2G3 PLA2G3 EGR1 EGR1 MFSD2A MFSD2A DGKQ DGKQ PROX1 PROX1 PPARG PPARG ENSUAMP00000002362 ENSUAMP00000002362 WDTC1 WDTC1 ENSUAMP00000002886 ENSUAMP00000002886 ENSUAMP00000002924 ENSUAMP00000002924 NR1H3 NR1H3 ENSUAMP00000004117 ENSUAMP00000004117 TRIB3 TRIB3 CLCN2 CLCN2 ANXA1 ANXA1 ETFBKMT ETFBKMT ENSUAMP00000006463 ENSUAMP00000006463 INSIG2 INSIG2 KCNMA1 KCNMA1 ENSUAMP00000006827 ENSUAMP00000006827 MLYCD MLYCD ATP2B4 ATP2B4 DKK3 DKK3 PDK4 PDK4 CAV1 CAV1 DKKL1 DKKL1 LPGAT1 LPGAT1 EIF6 EIF6 ENSUAMP00000009775 ENSUAMP00000009775 AKT1 AKT1 PPARA PPARA AKT3 AKT3 ENSUAMP00000012044 ENSUAMP00000012044 AKT2 AKT2 ENSUAMP00000037358 ENSUAMP00000037358 ERLIN1 ERLIN1 ENSUAMP00000036868 ENSUAMP00000036868 FGFR4 FGFR4 NR1H4 NR1H4 ABCD2 ABCD2 ENSUAMP00000035681 ENSUAMP00000035681 PANK2 PANK2 PDK2 PDK2 APPL2 APPL2 LONP2 LONP2 CD74 CD74 FGF19 FGF19 PDK1 PDK1 H6PD H6PD ATCAY ATCAY ERLIN2 ERLIN2 NCOR2 NCOR2 MID1IP1 MID1IP1 ENSUAMP00000030569 ENSUAMP00000030569 GIP GIP FMO4 FMO4 FMO1 FMO1 FMO2 FMO2 SLC7A7 SLC7A7 INS INS ENSUAMP00000026643 ENSUAMP00000026643 SOX9 SOX9 ENSUAMP00000026413 ENSUAMP00000026413 SCAP SCAP APOA4 APOA4 ENSUAMP00000025261 ENSUAMP00000025261 NCOR1 NCOR1 ELOVL5 ELOVL5 SIRT4 SIRT4 ABCB11 ABCB11 PLIN5 PLIN5 SLC7A11 SLC7A11 STARD4 STARD4 ENSUAMP00000023027 ENSUAMP00000023027 ENSUAMP00000023021 ENSUAMP00000023021 PRMT3 PRMT3 BMP2 BMP2 SIRT1 SIRT1 MLXIPL MLXIPL ENSUAMP00000020616 ENSUAMP00000020616 ENSUAMP00000020615 ENSUAMP00000020615 ADIPOQ ADIPOQ NR1D1 NR1D1 NR1H2 NR1H2 ACADVL ACADVL SIRT5 SIRT5 PPARD PPARD ENSUAMP00000016504 ENSUAMP00000016504 ENSUAMP00000016357 ENSUAMP00000016357 PARK7 PARK7 PPTC7 PPTC7 ENSUAMP00000012551 ENSUAMP00000012551 ENSUAMP00000012166 ENSUAMP00000012166
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PLA2G3Phospholipase A2 group III. (508 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (527 aa)
DGKQDiacylglycerol kinase. (950 aa)
PROX1Prospero homeobox 1. (737 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
ENSUAMP00000002362Uncharacterized protein. (354 aa)
WDTC1WD and tetratricopeptide repeats 1. (679 aa)
ENSUAMP00000002886Uncharacterized protein. (479 aa)
ENSUAMP00000002924Uncharacterized protein. (335 aa)
NR1H3Nuclear receptor subfamily 1 group H member 3. (447 aa)
ENSUAMP00000004117Uncharacterized protein. (393 aa)
TRIB3Tribbles pseudokinase 3. (363 aa)
CLCN2Chloride channel protein. (903 aa)
ANXA1Annexin. (345 aa)
ETFBKMTElectron transfer flavoprotein subunit beta lysine methyltransferase. (266 aa)
ENSUAMP00000006463Uncharacterized protein. (89 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (229 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1143 aa)
ENSUAMP00000006827CCDC144C domain-containing protein. (321 aa)
MLYCDMalonyl-CoA decarboxylase. (500 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1260 aa)
DKK3Dickkopf WNT signaling pathway inhibitor 3. (361 aa)
PDK4Protein-serine/threonine kinase. (412 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
DKKL1Dickkopf like acrosomal protein 1. (233 aa)
LPGAT1Lysophosphatidylglycerol acyltransferase 1. (263 aa)
EIF6Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)- dependent protein kinase C activity. In tissues responsive to insulin, contro [...] (245 aa)
ENSUAMP00000009775C2 domain-containing protein. (151 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
PPARAPeroxisome proliferator activated receptor alpha. (503 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
ENSUAMP00000012044TGF_BETA_2 domain-containing protein. (154 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
ENSUAMP00000037358Uncharacterized protein. (119 aa)
ERLIN1ER lipid raft associated 1. (348 aa)
ENSUAMP00000036868Uncharacterized protein. (379 aa)
FGFR4Fibroblast growth factor receptor. (836 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (482 aa)
ABCD2ATP binding cassette subfamily D member 2. (742 aa)
ENSUAMP00000035681Protein kinase domain-containing protein. (217 aa)
PANK2Pantothenate kinase 2. (451 aa)
PDK2Protein-serine/threonine kinase. (249 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (652 aa)
LONP2Lon protease homolog 2, peroxisomal; ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta- oxidation through degradation of the self-processed forms of TYSND1. (821 aa)
CD74CD74 molecule. (279 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
PDK1Protein-serine/threonine kinase. (438 aa)
H6PDHexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (804 aa)
ATCAYATCAY kinesin light chain interacting caytaxin. (355 aa)
ERLIN2ER lipid raft associated 2. (337 aa)
NCOR2Nuclear receptor corepressor 2. (2465 aa)
MID1IP1MID1 interacting protein 1. (183 aa)
ENSUAMP00000030569Uncharacterized protein. (137 aa)
GIPGastric inhibitory polypeptide. (176 aa)
FMO4Dimethylaniline monooxygenase [N-oxide-forming]. (556 aa)
FMO1Dimethylaniline monooxygenase [N-oxide-forming]. (532 aa)
FMO2Dimethylaniline monooxygenase [N-oxide-forming]. (535 aa)
SLC7A7Solute carrier family 7 member 7. (511 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (106 aa)
ENSUAMP00000026643Uncharacterized protein. (232 aa)
SOX9SRY-box transcription factor 9. (484 aa)
ENSUAMP00000026413ETS domain-containing protein. (843 aa)
SCAPSREBF chaperone. (1229 aa)
APOA4Apolipoprotein A4. (382 aa)
ENSUAMP00000025261GPS2_interact domain-containing protein. (204 aa)
NCOR1Nuclear receptor corepressor 1. (2267 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (312 aa)
ABCB11ATP binding cassette subfamily B member 11. (1319 aa)
PLIN5Perilipin; Belongs to the perilipin family. (457 aa)
SLC7A11Solute carrier family 7 member 11. (466 aa)
STARD4StAR related lipid transfer domain containing 4. (208 aa)
ENSUAMP00000023027Flavin-containing monooxygenase. (185 aa)
ENSUAMP00000023021Flavin-containing monooxygenase. (254 aa)
PRMT3Protein arginine methyltransferase 3; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (516 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SIRT1Sirtuin 1. (618 aa)
MLXIPLMLX interacting protein like. (829 aa)
ENSUAMP00000020616ABC transmembrane type-1 domain-containing protein. (206 aa)
ENSUAMP00000020615ABC transporter domain-containing protein. (230 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (600 aa)
NR1H2Nuclear receptor subfamily 1 group H member 2. (455 aa)
ACADVLAcyl-CoA dehydrogenase very long chain. (655 aa)
SIRT5NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...] (324 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
ENSUAMP00000016504BRCT domain-containing protein. (101 aa)
ENSUAMP00000016357Uncharacterized protein. (330 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
PPTC7Protein phosphatase; Belongs to the PP2C family. (304 aa)
ENSUAMP00000012551Battenin. (438 aa)
ENSUAMP00000012166FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (135 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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