34 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	BAMBI	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
	CRB2	Crumbs cell polarity complex component 2. (1280 aa)
	LRG1	Leucine rich alpha-2-glycoprotein 1. (354 aa)
	TBX20	T-box transcription factor 20. (448 aa)
	TCF7L2	Transcription factor 7 like 2. (524 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	ENG	Endoglin. (650 aa)
	ZNF703	Zinc finger protein 703. (592 aa)
	ENSUAMP00000031727	Uncharacterized protein. (91 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	ENSUAMP00000034664	SCP domain-containing protein. (92 aa)
	ENSUAMP00000034666	SCP domain-containing protein; Belongs to the CRISP family. (83 aa)
	SNAI1	Snail family transcriptional repressor 1. (259 aa)
	ENSUAMP00000035777	HMG box domain-containing protein. (191 aa)
	BCL9L	BCL9 like. (1497 aa)
	AXIN2	Axin 2. (843 aa)
	LOXL2	Lysyl oxidase like 2. (779 aa)
	ENSUAMP00000010127	Kindlin_2_N domain-containing protein. (70 aa)
	EMP2	Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
	ENSUAMP00000012266	CTNNB1_binding domain-containing protein. (162 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	DAB2	DAB adaptor protein 2. (763 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	CTNNB1	Catenin beta 1. (781 aa)
	TGFB1I1	Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (464 aa)
	WWTR1	WW domain containing transcription regulator 1. (400 aa)
	FERMT2	Fermitin family member 2. (567 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AXIN2	BMP4	ENSUAMP00000001279	ENSUAMP00000028868	Axin 2.	Bone morphogenetic protein 4.	0.535
AXIN2	CTNNB1	ENSUAMP00000001279	ENSUAMP00000017207	Axin 2.	Catenin beta 1.	0.996
AXIN2	ENSUAMP00000012266	ENSUAMP00000001279	ENSUAMP00000012266	Axin 2.	CTNNB1_binding domain-containing protein.	0.965
AXIN2	ENSUAMP00000035777	ENSUAMP00000001279	ENSUAMP00000035777	Axin 2.	HMG box domain-containing protein.	0.965
AXIN2	TCF7L2	ENSUAMP00000001279	ENSUAMP00000026084	Axin 2.	Transcription factor 7 like 2.	0.959
BAMBI	BMP2	ENSUAMP00000021739	ENSUAMP00000021596	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Bone morphogenetic protein 2.	0.532
BAMBI	BMP4	ENSUAMP00000021739	ENSUAMP00000028868	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Bone morphogenetic protein 4.	0.522
BAMBI	SMAD3	ENSUAMP00000021739	ENSUAMP00000026563	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.620
BAMBI	SMAD4	ENSUAMP00000021739	ENSUAMP00000018392	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Mothers against decapentaplegic homolog.	0.644
BAMBI	TGFB1	ENSUAMP00000021739	ENSUAMP00000012487	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.719
BAMBI	TGFBR1	ENSUAMP00000021739	ENSUAMP00000016865	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.965
BCL9L	CTNNB1	ENSUAMP00000036630	ENSUAMP00000017207	BCL9 like.	Catenin beta 1.	0.604
BCL9L	TCF7L2	ENSUAMP00000036630	ENSUAMP00000026084	BCL9 like.	Transcription factor 7 like 2.	0.502
BMP2	BAMBI	ENSUAMP00000021596	ENSUAMP00000021739	Bone morphogenetic protein 2.	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family.	0.532
BMP2	BMP4	ENSUAMP00000021596	ENSUAMP00000028868	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.943
BMP2	CTNNB1	ENSUAMP00000021596	ENSUAMP00000017207	Bone morphogenetic protein 2.	Catenin beta 1.	0.543
BMP2	SMAD3	ENSUAMP00000021596	ENSUAMP00000026563	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.617
BMP2	SMAD4	ENSUAMP00000021596	ENSUAMP00000018392	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.854
BMP2	TGFB1	ENSUAMP00000021596	ENSUAMP00000012487	Bone morphogenetic protein 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.459
BMP2	TGFB2	ENSUAMP00000021596	ENSUAMP00000020781	Bone morphogenetic protein 2.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.424