STRINGSTRING
RREB1 RREB1 UNC13D UNC13D DCT DCT NEDD9 NEDD9 PLAG1 PLAG1 HIF1A HIF1A NOTCH1 NOTCH1 ENSUAMP00000034052 ENSUAMP00000034052 DMTN DMTN ENSUAMP00000003003 ENSUAMP00000003003 ENSUAMP00000002985 ENSUAMP00000002985 FLNA FLNA ENSUAMP00000001956 ENSUAMP00000001956 ENSUAMP00000001946 ENSUAMP00000001946 ENSUAMP00000001879 ENSUAMP00000001879 ENSUAMP00000001632 ENSUAMP00000001632 EGR2 EGR2 ZNF365 ZNF365 ENSUAMP00000000397 ENSUAMP00000000397 ENSUAMP00000000316 ENSUAMP00000000316 GFAP GFAP SNW1 SNW1 ENSUAMP00000029322 ENSUAMP00000029322 SMARCD3 SMARCD3 IL6ST IL6ST METRNL METRNL TGM2 TGM2 ENSUAMP00000030353 ENSUAMP00000030353 DBN1 DBN1 OBSL1 OBSL1 ENSUAMP00000031091 ENSUAMP00000031091 NGF NGF ISLR ISLR LRRC45 LRRC45 FN1 FN1 GLI3 GLI3 AMIGO1 AMIGO1 IL34 IL34 LIF LIF MYOG MYOG ENSUAMP00000007446 ENSUAMP00000007446 TNFSF11 TNFSF11 MAN2A1 MAN2A1 ENSUAMP00000006800 ENSUAMP00000006800 CLCF1 CLCF1 NKX6-1 NKX6-1 DBNL DBNL ENSUAMP00000005058 ENSUAMP00000005058 LAYN LAYN TESK1 TESK1 ELL3 ELL3 SS18L1 SS18L1 ENSUAMP00000033177 ENSUAMP00000033177 ENSUAMP00000033204 ENSUAMP00000033204 F11R F11R TNFRSF1B TNFRSF1B CDH5 CDH5 ENSUAMP00000008298 ENSUAMP00000008298 CRKL CRKL AMIGO3 AMIGO3 ANKRD27 ANKRD27 LPAR3 LPAR3 HES1 HES1 SERPINE2 SERPINE2 WNT2 WNT2 EFNA5 EFNA5 ABL1 ABL1 ITGB1 ITGB1 ASCL1 ASCL1 ENSUAMP00000010127 ENSUAMP00000010127 STK25 STK25 CLDN5 CLDN5 PRKDC PRKDC TENM4 TENM4 CLEC7A CLEC7A NEFL NEFL RASSF10 RASSF10 MAP3K13 MAP3K13 BIN1 BIN1 SPEN SPEN ENSUAMP00000012039 ENSUAMP00000012039 ENSUAMP00000012254 ENSUAMP00000012254 RELN RELN CAPRIN1 CAPRIN1 WNT3A WNT3A TGFB1 TGFB1 ZFYVE27 ZFYVE27 MEGF8 MEGF8 SIRT2 SIRT2 VEGFC VEGFC RNF112 RNF112 NUMBL NUMBL PLXNA3 PLXNA3 ENSUAMP00000015063 ENSUAMP00000015063 SLITRK1 SLITRK1 ENSUAMP00000015168 ENSUAMP00000015168 ENSUAMP00000015412 ENSUAMP00000015412 ENSUAMP00000015416 ENSUAMP00000015416 PROC PROC SEMA7A SEMA7A ENSUAMP00000015652 ENSUAMP00000015652 TNF TNF SOX8 SOX8 PAFAH1B1 PAFAH1B1 KHDC3L KHDC3L ENSUAMP00000016192 ENSUAMP00000016192 NUMB NUMB CRK CRK TRIB1 TRIB1 CTNNB1 CTNNB1 FERMT2 FERMT2 HOXA11 HOXA11 NIN NIN ENSUAMP00000018309 ENSUAMP00000018309 ACTN3 ACTN3 PLXNB2 PLXNB2 ROCK1 ROCK1 PRKCI PRKCI ENSUAMP00000019144 ENSUAMP00000019144 ENSUAMP00000019152 ENSUAMP00000019152 BAD BAD MTOR MTOR SERPINF1 SERPINF1 SRF SRF ENSUAMP00000020065 ENSUAMP00000020065 ENSUAMP00000020068 ENSUAMP00000020068 ENSUAMP00000020075 ENSUAMP00000020075 ENSUAMP00000020176 ENSUAMP00000020176 ADIPOQ ADIPOQ MYADM MYADM TRPV2 TRPV2 SEMA4D SEMA4D KRAS KRAS BNC1 BNC1 PDE3A PDE3A ENSUAMP00000021520 ENSUAMP00000021520 P4HB P4HB BMP2 BMP2 DHX36 DHX36 MYF5 MYF5 MYF6 MYF6 ENSUAMP00000022072 ENSUAMP00000022072 FZD3 FZD3 FAIM FAIM GOLGA4 GOLGA4 ENSUAMP00000022406 ENSUAMP00000022406 ENSUAMP00000022666 ENSUAMP00000022666 ENSUAMP00000022692 ENSUAMP00000022692 NEURL1 NEURL1 ENSUAMP00000023172 ENSUAMP00000023172 CX3CR1 CX3CR1 ENSUAMP00000023517 ENSUAMP00000023517 CASS4 CASS4 ENSUAMP00000024079 ENSUAMP00000024079 ENSUAMP00000024399 ENSUAMP00000024399 LRP2 LRP2 BRAF BRAF OTP OTP ENSUAMP00000024890 ENSUAMP00000024890 CIB1 CIB1 NPTN NPTN SHTN1 SHTN1 S1PR2 S1PR2 IST1 IST1 CDC42 CDC42 MECP2 MECP2 ENSUAMP00000026454 ENSUAMP00000026454 ENSUAMP00000026458 ENSUAMP00000026458 SOX10 SOX10 PTN PTN TWF2 TWF2 CDKL5 CDKL5 SMAD7 SMAD7 NKX6-2 NKX6-2 DMRTA2 DMRTA2 SMO SMO ENSUAMP00000027842 ENSUAMP00000027842 ENSUAMP00000027843 ENSUAMP00000027843 ENSUAMP00000027877 ENSUAMP00000027877 ZNF335 ZNF335 ENSUAMP00000028558 ENSUAMP00000028558 ENSUAMP00000028596 ENSUAMP00000028596 BMP4 BMP4 UFL1 UFL1 POU4F2 POU4F2 ILK ILK PLXNA1 PLXNA1 OLIG2 OLIG2 ASPA ASPA PREX1 PREX1 SRRT SRRT BMPR2 BMPR2 ENSUAMP00000036884 ENSUAMP00000036884 PLXNA4 PLXNA4 LIMS2 LIMS2 NR2E1 NR2E1 SLC9B2 SLC9B2 CHODL CHODL WNT3 WNT3 ZNF488 ZNF488 XRCC2 XRCC2 LIMK1 LIMK1 GPER1 GPER1 TRIM32 TRIM32 ENSUAMP00000004785 ENSUAMP00000004785 OPRM1 OPRM1 XRCC5 XRCC5 LIG4 LIG4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RREB1Ras responsive element binding protein 1. (1767 aa)
UNC13DUnc-13 homolog D. (1091 aa)
DCTDopachrome tautomerase. (400 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (828 aa)
PLAG1PLAG1 zinc finger. (499 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
NOTCH1Notch receptor 1. (2547 aa)
ENSUAMP00000034052Uncharacterized protein. (70 aa)
DMTNDematin actin binding protein. (396 aa)
ENSUAMP00000003003Plexin_cytopl domain-containing protein. (490 aa)
ENSUAMP00000002985Ig-like domain-containing protein. (746 aa)
FLNAFilamin A. (1660 aa)
ENSUAMP00000001956LIM zinc-binding domain-containing protein. (108 aa)
ENSUAMP00000001946Uncharacterized protein. (119 aa)
ENSUAMP00000001879Protein kinase domain-containing protein. (335 aa)
ENSUAMP00000001632S_100 domain-containing protein; Belongs to the S-100 family. (97 aa)
EGR2Early growth response 2. (471 aa)
ZNF365Zinc finger protein 365. (407 aa)
ENSUAMP00000000397Paired domain-containing protein. (216 aa)
ENSUAMP00000000316Homeobox domain-containing protein. (280 aa)
GFAPGlial fibrillary acidic protein; Belongs to the intermediate filament family. (432 aa)
SNW1SNW domain containing 1. (511 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
METRNLMeteorin like, glial cell differentiation regulator. (311 aa)
TGM2Transglutaminase 2. (687 aa)
ENSUAMP00000030353C2 domain-containing protein. (165 aa)
DBN1Drebrin 1. (698 aa)
OBSL1Obscurin like 1. (1886 aa)
ENSUAMP00000031091Uncharacterized protein. (151 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (240 aa)
ISLRImmunoglobulin superfamily containing leucine rich repeat. (428 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
FN1Fibronectin 1. (2385 aa)
GLI3GLI family zinc finger 3. (1413 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (493 aa)
IL34Interleukin 34. (236 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
MYOGMyogenin. (224 aa)
ENSUAMP00000007446WD_REPEATS_REGION domain-containing protein. (380 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
MAN2A1Alpha-mannosidase. (1096 aa)
ENSUAMP00000006800Uncharacterized protein. (97 aa)
CLCF1Cardiotrophin like cytokine factor 1. (215 aa)
NKX6-1NK6 homeobox 1. (366 aa)
DBNLDrebrin like. (438 aa)
ENSUAMP00000005058PID domain-containing protein. (79 aa)
LAYNLayilin. (372 aa)
TESK1Testis associated actin remodelling kinase 1. (628 aa)
ELL3Elongation factor for RNA polymerase II 3. (414 aa)
SS18L1SS18L1 subunit of BAF chromatin remodeling complex. (396 aa)
ENSUAMP00000033177Homeobox domain-containing protein. (381 aa)
ENSUAMP00000033204annotation not available (722 aa)
F11RF11 receptor. (298 aa)
TNFRSF1BTNF receptor superfamily member 1B. (460 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
ENSUAMP00000008298AGC-kinase C-terminal domain-containing protein. (89 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
AMIGO3Adhesion molecule with Ig like domain 3. (510 aa)
ANKRD27Ankyrin repeat domain 27. (1050 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (354 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (232 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (188 aa)
ABL1Tyrosine-protein kinase. (1138 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (771 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (213 aa)
ENSUAMP00000010127Kindlin_2_N domain-containing protein. (70 aa)
STK25Serine/threonine kinase 25. (426 aa)
CLDN5Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3341 aa)
TENM4Teneurin transmembrane protein 4. (2640 aa)
CLEC7AC-type lectin domain containing 7A. (237 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (505 aa)
RASSF10Ras association domain family member 10. (497 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
BIN1Bridging integrator 1. (686 aa)
SPENSpen family transcriptional repressor. (3674 aa)
ENSUAMP00000012039Uncharacterized protein. (457 aa)
ENSUAMP00000012254Arm_2 domain-containing protein. (550 aa)
RELNReelin. (3263 aa)
CAPRIN1Cell cycle associated protein 1. (709 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (404 aa)
MEGF8Multiple EGF like domains 8. (2820 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (426 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (391 aa)
RNF112Ring finger protein 112. (630 aa)
NUMBLNUMB like endocytic adaptor protein. (582 aa)
PLXNA3Plexin A3. (1794 aa)
ENSUAMP00000015063Uncharacterized protein. (446 aa)
SLITRK1SLIT and NTRK like family member 1. (696 aa)
ENSUAMP00000015168Uncharacterized protein. (119 aa)
ENSUAMP00000015412C1q domain-containing protein. (490 aa)
ENSUAMP00000015416Uncharacterized protein. (479 aa)
PROCProtein C, inactivator of coagulation factors Va and VIIIa. (477 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (663 aa)
ENSUAMP00000015652Aldolase_II domain-containing protein. (400 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
SOX8SRY-box transcription factor 8. (449 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
KHDC3LKH domain containing 3 like, subcortical maternal complex member. (215 aa)
ENSUAMP00000016192Integrin beta; Belongs to the integrin beta chain family. (786 aa)
NUMBNUMB endocytic adaptor protein. (509 aa)
CRKCRK proto-oncogene, adaptor protein. (204 aa)
TRIB1Tribbles pseudokinase 1. (317 aa)
CTNNB1Catenin beta 1. (781 aa)
FERMT2Fermitin family member 2. (567 aa)
HOXA11Homeobox A11. (313 aa)
NINNinein. (2134 aa)
ENSUAMP00000018309Uncharacterized protein. (85 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (942 aa)
PLXNB2Plexin B2. (1841 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1365 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (587 aa)
ENSUAMP00000019144Plexin_cytopl domain-containing protein. (215 aa)
ENSUAMP00000019152Sema domain-containing protein. (489 aa)
BADBCL2 associated agonist of cell death. (168 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
SERPINF1Serpin family F member 1; Belongs to the serpin family. (418 aa)
SRFSerum response factor. (507 aa)
ENSUAMP00000020065Uncharacterized protein. (232 aa)
ENSUAMP00000020068Uncharacterized protein. (119 aa)
ENSUAMP00000020075Uncharacterized protein. (245 aa)
ENSUAMP00000020176S_100 domain-containing protein; Belongs to the S-100 family. (91 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
MYADMMyeloid associated differentiation marker. (322 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (801 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (976 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
BNC1Basonuclin 1. (1021 aa)
PDE3APhosphodiesterase. (777 aa)
ENSUAMP00000021520Uncharacterized protein. (210 aa)
P4HBProtein disulfide-isomerase. (510 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
DHX36DEAH-box helicase 36. (964 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (255 aa)
MYF6Myogenic factor 6. (242 aa)
ENSUAMP00000022072Uncharacterized protein. (574 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
FAIMFas apoptotic inhibitory molecule. (201 aa)
GOLGA4Golgin A4. (2252 aa)
ENSUAMP00000022406Uncharacterized protein. (242 aa)
ENSUAMP00000022666DH domain-containing protein. (692 aa)
ENSUAMP00000022692Plexin_cytopl domain-containing protein. (407 aa)
NEURL1Neuralized E3 ubiquitin protein ligase 1. (575 aa)
ENSUAMP00000023172Uncharacterized protein. (275 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
ENSUAMP00000023517Laminin N-terminal domain-containing protein. (378 aa)
CASS4Cas scaffold protein family member 4. (803 aa)
ENSUAMP00000024079Uncharacterized protein; Belongs to the parvalbumin family. (109 aa)
ENSUAMP00000024399Plexin_cytopl domain-containing protein. (604 aa)
LRP2LDL receptor related protein 2. (4684 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
OTPOrthopedia homeobox. (325 aa)
ENSUAMP00000024890Uncharacterized protein. (134 aa)
CIB1Calcium and integrin binding 1. (191 aa)
NPTNNeuroplastin. (361 aa)
SHTN1Shootin 1. (647 aa)
S1PR2Sphingosine-1-phosphate receptor 2; Belongs to the G-protein coupled receptor 1 family. (352 aa)
IST1IST1 factor associated with ESCRT-III. (366 aa)
CDC42Cell division cycle 42. (191 aa)
MECP2Methyl-CpG binding protein 2. (440 aa)
ENSUAMP00000026454Uncharacterized protein. (103 aa)
ENSUAMP00000026458PH domain-containing protein. (580 aa)
SOX10SRY-box transcription factor 10. (465 aa)
PTNPleiotrophin. (218 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
CDKL5Cyclin dependent kinase like 5. (971 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
NKX6-2NK6 homeobox 2. (269 aa)
DMRTA2DMRT like family A2. (514 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
ENSUAMP00000027842Uncharacterized protein. (99 aa)
ENSUAMP00000027843Uncharacterized protein. (119 aa)
ENSUAMP00000027877PA14 domain-containing protein. (741 aa)
ZNF335Zinc finger protein 335. (1349 aa)
ENSUAMP00000028558Uncharacterized protein. (222 aa)
ENSUAMP00000028596IGv domain-containing protein. (133 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
UFL1UFM1 specific ligase 1. (516 aa)
POU4F2POU domain protein. (408 aa)
ILKIntegrin linked kinase. (503 aa)
PLXNA1Plexin A1. (1852 aa)
OLIG2Oligodendrocyte transcription factor 2. (302 aa)
ASPAAspartoacylase. (313 aa)
PREX1Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1. (1627 aa)
SRRTSerrate, RNA effector molecule. (850 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
ENSUAMP00000036884Plexin_cytopl domain-containing protein. (55 aa)
PLXNA4Plexin A4. (1850 aa)
LIMS2LIM and senescent cell antigen-like-containing domain protein; Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. (341 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
CHODLChondrolectin. (267 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
ZNF488Zinc finger protein 488. (324 aa)
XRCC2X-ray repair cross complementing 2. (281 aa)
LIMK1LIM domain kinase 1. (580 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
TRIM32Tripartite motif containing 32. (655 aa)
ENSUAMP00000004785Uncharacterized protein. (428 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (450 aa)
XRCC5X-ray repair cross complementing 5. (501 aa)
LIG4DNA ligase. (911 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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