STRINGSTRING
GDF2 GDF2 GDF10 GDF10 GDF6 GDF6 ENSUAMP00000001661 ENSUAMP00000001661 ENSUAMP00000004313 ENSUAMP00000004313 TWSG1 TWSG1 INHBA INHBA ENSUAMP00000008401 ENSUAMP00000008401 GDF5 GDF5 NODAL NODAL SDCBP SDCBP ENSUAMP00000012044 ENSUAMP00000012044 TGFB1 TGFB1 GDF3 GDF3 DAB2 DAB2 ENSUAMP00000015431 ENSUAMP00000015431 ENSUAMP00000015435 ENSUAMP00000015435 BMP10 BMP10 TGFB3 TGFB3 ENSUAMP00000016756 ENSUAMP00000016756 TGFBR1 TGFBR1 ACVRL1 ACVRL1 SMAD4 SMAD4 GDF11 GDF11 HFE HFE BMP2 BMP2 INHBC INHBC INHBE INHBE ENSUAMP00000025766 ENSUAMP00000025766 BMP4 BMP4 ENG ENG INHA INHA BMP3 BMP3 ENSUAMP00000034691 ENSUAMP00000034691 BMPR1A BMPR1A BMPR2 BMPR2 ENSUAMP00000037566 ENSUAMP00000037566
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDF2Growth differentiation factor 2. (429 aa)
GDF10Growth differentiation factor 10. (483 aa)
GDF6Growth differentiation factor 6. (289 aa)
ENSUAMP00000001661TGF_BETA_2 domain-containing protein. (194 aa)
ENSUAMP00000004313Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (64 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (202 aa)
INHBAInhibin subunit beta A. (424 aa)
ENSUAMP00000008401TGF_BETA_2 domain-containing protein. (367 aa)
GDF5Growth differentiation factor 5. (499 aa)
NODALNodal growth differentiation factor. (348 aa)
SDCBPSyndecan binding protein. (317 aa)
ENSUAMP00000012044TGF_BETA_2 domain-containing protein. (154 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
GDF3Growth differentiation factor 3. (365 aa)
DAB2DAB adaptor protein 2. (763 aa)
ENSUAMP00000015431Uncharacterized protein. (297 aa)
ENSUAMP00000015435Uncharacterized protein. (194 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSUAMP00000016756Uncharacterized protein. (210 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GDF11Growth differentiation factor 11. (409 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (355 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
INHBCInhibin subunit beta C. (352 aa)
INHBEInhibin subunit beta E. (351 aa)
ENSUAMP00000025766Uncharacterized protein. (229 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ENGEndoglin. (650 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
ENSUAMP00000034691RRM domain-containing protein. (153 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
ENSUAMP00000037566TGF_BETA_2 domain-containing protein. (293 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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