(19 nodes) Negative regulation of steroid biosynthetic process network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ERLIN1	ER lipid raft associated 1. (348 aa)
	ENSUAMP00000012044	TGF_BETA_2 domain-containing protein. (154 aa)
	ENSUAMP00000002924	Uncharacterized protein. (335 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (229 aa)
	CYP27C1	Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa)
	DKKL1	Dickkopf like acrosomal protein 1. (233 aa)
	CYP27B1	Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
	DKK3	Dickkopf WNT signaling pathway inhibitor 3. (361 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	ENSUAMP00000002362	Uncharacterized protein. (354 aa)
	ENSUAMP00000002886	Uncharacterized protein. (479 aa)
	SNAI2	Snail family transcriptional repressor 2. (230 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	GFI1	Growth factor independent 1 transcriptional repressor. (448 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (471 aa)
	APOE	Apolipoprotein E. (323 aa)
	ERLIN2	ER lipid raft associated 2. (337 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (215 aa)
	SNAI1	Snail family transcriptional repressor 1. (259 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP2	ENSUAMP00000012044	ENSUAMP00000021596	ENSUAMP00000012044	Bone morphogenetic protein 2.	TGF_BETA_2 domain-containing protein.	0.730
BMP2	FGF19	ENSUAMP00000021596	ENSUAMP00000032520	Bone morphogenetic protein 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.534
ENSUAMP00000012044	BMP2	ENSUAMP00000012044	ENSUAMP00000021596	TGF_BETA_2 domain-containing protein.	Bone morphogenetic protein 2.	0.730
ERLIN1	ERLIN2	ENSUAMP00000036963	ENSUAMP00000030936	ER lipid raft associated 1.	ER lipid raft associated 2.	0.991
ERLIN2	ERLIN1	ENSUAMP00000030936	ENSUAMP00000036963	ER lipid raft associated 2.	ER lipid raft associated 1.	0.991
FGF19	BMP2	ENSUAMP00000032520	ENSUAMP00000021596	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 2.	0.534
SNAI1	SNAI2	ENSUAMP00000035021	ENSUAMP00000018871	Snail family transcriptional repressor 1.	Snail family transcriptional repressor 2.	0.470
SNAI2	SNAI1	ENSUAMP00000018871	ENSUAMP00000035021	Snail family transcriptional repressor 2.	Snail family transcriptional repressor 1.	0.470