STRINGSTRING
HTR2B HTR2B ENSUAMP00000002165 ENSUAMP00000002165 CYP26C1 CYP26C1 ACVR1 ACVR1 ENSUAMP00000004593 ENSUAMP00000004593 ENSUAMP00000004725 ENSUAMP00000004725 ENSUAMP00000004728 ENSUAMP00000004728 ENSUAMP00000005111 ENSUAMP00000005111 PEF1 PEF1 ENSUAMP00000005739 ENSUAMP00000005739 EFNB1 EFNB1 SEMA3E SEMA3E SEMA6D SEMA6D HAND2 HAND2 SEMA3G SEMA3G RDH10 RDH10 ENSUAMP00000009188 ENSUAMP00000009188 HES1 HES1 PHACTR4 PHACTR4 SEMA6A SEMA6A RADIL RADIL PHOX2B PHOX2B ENSUAMP00000013328 ENSUAMP00000013328 MAPK1 MAPK1 ENSUAMP00000015361 ENSUAMP00000015361 ENSUAMP00000015416 ENSUAMP00000015416 SEMA7A SEMA7A SOX8 SOX8 SEMA4A SEMA4A SNAI2 SNAI2 SEMA4D SEMA4D NRP2 NRP2 ENSUAMP00000021252 ENSUAMP00000021252 GDNF GDNF CITED2 CITED2 KLHL12 KLHL12 SEMA4G SEMA4G SEMA4F SEMA4F SEMA6B SEMA6B SEMA4B SEMA4B SEMA3C SEMA3C SOX10 SOX10 SOX9 SOX9 SMO SMO PDCD6 PDCD6 KITLG KITLG EDN1 EDN1 ANXA6 ANXA6 SEMA4C SEMA4C CORO1C CORO1C RET RET MAPK3 MAPK3 GBX2 GBX2 NRTN NRTN FN1 FN1 TCOF1 TCOF1 SEMA3D SEMA3D HIF1A HIF1A JAG1 JAG1 SEMA6C SEMA6C BMPR1A BMPR1A NOLC1 NOLC1 SEMA3B SEMA3B SEMA3F SEMA3F
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
ENSUAMP00000002165Sema domain-containing protein; Belongs to the semaphorin family. (424 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ENSUAMP00000004593Uncharacterized protein. (64 aa)
ENSUAMP00000004725G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ENSUAMP00000004728G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
ENSUAMP00000005111Aldedh domain-containing protein. (208 aa)
PEF1Penta-EF-hand domain containing 1. (289 aa)
ENSUAMP00000005739BTB domain-containing protein. (58 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (328 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1086 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (712 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
ENSUAMP00000009188Sema domain-containing protein; Belongs to the semaphorin family. (541 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
PHACTR4Phosphatase and actin regulator. (706 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (619 aa)
RADILRap associating with DIL domain. (1206 aa)
PHOX2BPaired like homeobox 2B. (289 aa)
ENSUAMP00000013328Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (237 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ENSUAMP00000015361CUB domain-containing protein. (131 aa)
ENSUAMP00000015416Uncharacterized protein. (479 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (663 aa)
SOX8SRY-box transcription factor 8. (449 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (755 aa)
SNAI2Snail family transcriptional repressor 2. (230 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (976 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (851 aa)
ENSUAMP00000021252Uncharacterized protein. (409 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
KLHL12Kelch like family member 12. (568 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (822 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (762 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (764 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (831 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
SOX10SRY-box transcription factor 10. (465 aa)
SOX9SRY-box transcription factor 9. (484 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
PDCD6Programmed cell death 6. (189 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
EDN1Endothelin 1. (202 aa)
ANXA6Annexin. (673 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1121 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
NRTNNeurturin. (157 aa)
FN1Fibronectin 1. (2385 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1383 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (949 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (711 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (773 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (662 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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