(46 nodes) Cholesterol binding network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ERLIN1	ER lipid raft associated 1. (348 aa)
	ENSUAMP00000023390	Uncharacterized protein. (286 aa)
	SOAT1	O-acyltransferase. (513 aa)
	ENSUAMP00000023301	Uncharacterized protein. (133 aa)
	APOA4	Apolipoprotein A4. (382 aa)
	ENSUAMP00000028494	Uncharacterized protein. (128 aa)
	ENSUAMP00000028498	Uncharacterized protein. (135 aa)
	SYP	Synaptophysin. (311 aa)
	PROM2	Prominin 2. (835 aa)
	OSBPL1A	Oxysterol-binding protein; Belongs to the OSBP family. (856 aa)
	NPC1	NPC intracellular cholesterol transporter 1. (1278 aa)
	ENSUAMP00000030084	VASt domain-containing protein. (439 aa)
	ANXA6	Annexin. (673 aa)
	ERLIN2	ER lipid raft associated 2. (337 aa)
	GRAMD1A	GRAM domain containing 1A. (805 aa)
	STARD3	StAR related lipid transfer domain containing 3. (445 aa)
	GRAMD1C	GRAM domain containing 1C. (420 aa)
	ENSUAMP00000008156	Uncharacterized protein. (93 aa)
	PTCH1	Patched 1. (1453 aa)
	FABP9	Fatty acid binding protein 9; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
	PMP2	Peripheral myelin protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	CD81	Tetraspanin. (392 aa)
	OSBPL3	Oxysterol-binding protein; Belongs to the OSBP family. (891 aa)
	STARD5	StAR related lipid transfer domain containing 5. (213 aa)
	SIDT1	SID1 transmembrane family member 1. (791 aa)
	SCARB2	Scavenger receptor class B member 2; Belongs to the CD36 family. (317 aa)
	SYNPR	Synaptoporin. (260 aa)
	NPC2	NPC intracellular cholesterol transporter 2. (149 aa)
	OSBP2	Oxysterol-binding protein; Belongs to the OSBP family. (744 aa)
	OSBPL7	Oxysterol binding protein like 7. (941 aa)
	FABP12	Fatty acid binding protein 12; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (150 aa)
	STAR	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (285 aa)
	OSBPL8	Oxysterol binding protein like 8. (534 aa)
	STARD4	StAR related lipid transfer domain containing 4. (208 aa)
	PROM1	Prominin 1. (812 aa)
	NFE2L1	Nuclear factor, erythroid 2 like 1. (798 aa)
	SOAT2	Sterol O-acyltransferase 2; Belongs to the membrane-bound acyltransferase family. (370 aa)
	SCP2	Sterol carrier protein 2. (457 aa)
	APOD	Apolipoprotein D. (189 aa)
	STARD3NL	STARD3 N-terminal like. (132 aa)
	NPC1L1	NPC1 like intracellular cholesterol transporter 1. (1353 aa)
	OSBPL6	Oxysterol-binding protein; Belongs to the OSBP family. (954 aa)
	ENSUAMP00000034850	Uncharacterized protein. (294 aa)
	APOF	Apolipoprotein F. (315 aa)
	TSPO2	Translocator protein 2. (174 aa)
	OSBPL5	Oxysterol-binding protein; Belongs to the OSBP family. (904 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOD	APOF	ENSUAMP00000015593	ENSUAMP00000034900	Apolipoprotein D.	Apolipoprotein F.	0.527
APOF	APOD	ENSUAMP00000034900	ENSUAMP00000015593	Apolipoprotein F.	Apolipoprotein D.	0.527
APOF	SOAT1	ENSUAMP00000034900	ENSUAMP00000024338	Apolipoprotein F.	O-acyltransferase.	0.450
APOF	SOAT2	ENSUAMP00000034900	ENSUAMP00000021650	Apolipoprotein F.	Sterol O-acyltransferase 2; Belongs to the membrane-bound acyltransferase family.	0.451
CD81	NPC1L1	ENSUAMP00000031375	ENSUAMP00000017893	Tetraspanin.	NPC1 like intracellular cholesterol transporter 1.	0.469
CD81	SCARB2	ENSUAMP00000031375	ENSUAMP00000012133	Tetraspanin.	Scavenger receptor class B member 2; Belongs to the CD36 family.	0.453
ENSUAMP00000023301	NPC1	ENSUAMP00000023301	ENSUAMP00000013659	Uncharacterized protein.	NPC intracellular cholesterol transporter 1.	0.421
ENSUAMP00000023301	NPC1L1	ENSUAMP00000023301	ENSUAMP00000017893	Uncharacterized protein.	NPC1 like intracellular cholesterol transporter 1.	0.418
ENSUAMP00000023301	OSBPL8	ENSUAMP00000023301	ENSUAMP00000023298	Uncharacterized protein.	Oxysterol binding protein like 8.	0.656
ENSUAMP00000023390	ENSUAMP00000034850	ENSUAMP00000023390	ENSUAMP00000034850	Uncharacterized protein.	Uncharacterized protein.	0.543
ENSUAMP00000023390	STAR	ENSUAMP00000023390	ENSUAMP00000004469	Uncharacterized protein.	Steroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone.	0.889
ENSUAMP00000023390	STARD3	ENSUAMP00000023390	ENSUAMP00000011524	Uncharacterized protein.	StAR related lipid transfer domain containing 3.	0.873
ENSUAMP00000023390	TSPO2	ENSUAMP00000023390	ENSUAMP00000036528	Uncharacterized protein.	Translocator protein 2.	0.898
ENSUAMP00000028494	ENSUAMP00000028498	ENSUAMP00000028494	ENSUAMP00000028498	Uncharacterized protein.	Uncharacterized protein.	0.882
ENSUAMP00000028494	ENSUAMP00000030084	ENSUAMP00000028494	ENSUAMP00000030084	Uncharacterized protein.	VASt domain-containing protein.	0.899
ENSUAMP00000028494	GRAMD1C	ENSUAMP00000028494	ENSUAMP00000011351	Uncharacterized protein.	GRAM domain containing 1C.	0.815
ENSUAMP00000028494	NPC1	ENSUAMP00000028494	ENSUAMP00000013659	Uncharacterized protein.	NPC intracellular cholesterol transporter 1.	0.416
ENSUAMP00000028498	ENSUAMP00000028494	ENSUAMP00000028498	ENSUAMP00000028494	Uncharacterized protein.	Uncharacterized protein.	0.882
ENSUAMP00000028498	ENSUAMP00000030084	ENSUAMP00000028498	ENSUAMP00000030084	Uncharacterized protein.	VASt domain-containing protein.	0.807
ENSUAMP00000028498	GRAMD1C	ENSUAMP00000028498	ENSUAMP00000011351	Uncharacterized protein.	GRAM domain containing 1C.	0.650