STRINGSTRING
ZNF451 ZNF451 STRAP STRAP CDKN2B CDKN2B TP53 TP53 LINGO3 LINGO3 HIPK2 HIPK2 LATS2 LATS2 EID2 EID2 ENSUAMP00000001764 ENSUAMP00000001764 ENSUAMP00000001879 ENSUAMP00000001879 ZEB1 ZEB1 LDLRAD4 LDLRAD4 ENSUAMP00000003640 ENSUAMP00000003640 SPRED1 SPRED1 LEMD3 LEMD3 SNX25 SNX25 VASN VASN ENSUAMP00000006566 ENSUAMP00000006566 ENSUAMP00000006610 ENSUAMP00000006610 ENSUAMP00000006800 ENSUAMP00000006800 LATS1 LATS1 ENSUAMP00000006938 ENSUAMP00000006938 ENSUAMP00000007497 ENSUAMP00000007497 RNF111 RNF111 EMILIN1 EMILIN1 LOX LOX CAV1 CAV1 FBN1 FBN1 SPRY2 SPRY2 ENSUAMP00000009946 ENSUAMP00000009946 MYOCD MYOCD ENSUAMP00000010402 ENSUAMP00000010402 ENSUAMP00000010405 ENSUAMP00000010405 TGFBR3 TGFBR3 SDCBP SDCBP MPP5 MPP5 PPM1A PPM1A WFIKKN2 WFIKKN2 TGFB1 TGFB1 CIDEA CIDEA HTRA3 HTRA3 PBLD PBLD PRDM16 PRDM16 DAB2 DAB2 PDPK1 PDPK1 FERMT1 FERMT1 SMURF2 SMURF2 ASPN ASPN TGFB1I1 TGFB1I1 ENSUAMP00000017634 ENSUAMP00000017634 ITGA3 ITGA3 HSPA5 HSPA5 SMAD4 SMAD4 SKIL SKIL NRROS NRROS AXIN1 AXIN1 ING2 ING2 SIRT1 SIRT1 BMP2 BMP2 BAMBI BAMBI GIPC3 GIPC3 ENSUAMP00000021865 ENSUAMP00000021865 THBS1 THBS1 GIPC1 GIPC1 CITED2 CITED2 ENSUAMP00000023083 ENSUAMP00000023083 CITED1 CITED1 ENSUAMP00000023807 ENSUAMP00000023807 ENSUAMP00000023809 ENSUAMP00000023809 SKI SKI PIN1 PIN1 ENSUAMP00000024123 ENSUAMP00000024123 IL17F IL17F LRG1 LRG1 SPRY1 SPRY1 WFIKKN1 WFIKKN1 ENSUAMP00000025354 ENSUAMP00000025354 IL17RD IL17RD PMEPA1 PMEPA1 ENSUAMP00000025766 ENSUAMP00000025766 GLG1 GLG1 SMAD3 SMAD3 SMAD6 SMAD6 RASL11B RASL11B SMAD7 SMAD7 ENSUAMP00000027731 ENSUAMP00000027731 TGFBR3L TGFBR3L SLC2A10 SLC2A10 ZBTB7A ZBTB7A SNW1 SNW1 ENG ENG ENSUAMP00000030338 ENSUAMP00000030338 LTBP1 LTBP1 CREBBP CREBBP ZNF703 ZNF703 CAV3 CAV3 NKX2-1 NKX2-1 EP300 EP300 NPNT NPNT C20orf27 C20orf27 WNT1 WNT1 BCL9L BCL9L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ZNF451Zinc finger protein 451. (1012 aa)
STRAPSerine/threonine kinase receptor associated protein. (350 aa)
CDKN2BCyclin dependent kinase inhibitor 2B. (138 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LINGO3Leucine rich repeat and Ig domain containing 3. (539 aa)
HIPK2Homeodomain interacting protein kinase 2. (1200 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
EID2EP300 interacting inhibitor of differentiation 2. (172 aa)
ENSUAMP00000001764Uncharacterized protein. (55 aa)
ENSUAMP00000001879Protein kinase domain-containing protein. (335 aa)
ZEB1Zinc finger E-box binding homeobox 1. (1017 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (269 aa)
ENSUAMP00000003640Uncharacterized protein. (101 aa)
SPRED1Sprouty related EVH1 domain containing 1. (445 aa)
LEMD3LEM domain containing 3. (929 aa)
SNX25Sorting nexin 25. (889 aa)
VASNVasorin. (676 aa)
ENSUAMP00000006566UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
ENSUAMP00000006610CUT domain-containing protein. (259 aa)
ENSUAMP00000006800Uncharacterized protein. (97 aa)
LATS1Uncharacterized protein. (1012 aa)
ENSUAMP00000006938Uncharacterized protein. (133 aa)
ENSUAMP00000007497Uncharacterized protein. (66 aa)
RNF111Ring finger protein 111. (985 aa)
EMILIN1Elastin microfibril interfacer 1. (1020 aa)
LOXLysyl oxidase. (414 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
FBN1Fibrillin 1. (2348 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
ENSUAMP00000009946Uncharacterized protein. (224 aa)
MYOCDMyocardin. (870 aa)
ENSUAMP00000010402BBC domain-containing protein. (492 aa)
ENSUAMP00000010405Uncharacterized protein. (120 aa)
TGFBR3Transforming growth factor beta receptor 3. (808 aa)
SDCBPSyndecan binding protein. (317 aa)
MPP5Membrane palmitoylated protein 5; Belongs to the MAGUK family. (675 aa)
PPM1AProtein phosphatase, Mg2+/Mn2+ dependent 1A. (382 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (573 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
CIDEACell death inducing DFFA like effector a. (207 aa)
HTRA3HtrA serine peptidase 3. (474 aa)
PBLDPhenazine biosynthesis like protein domain containing. (266 aa)
PRDM16PR/SET domain 16. (1235 aa)
DAB2DAB adaptor protein 2. (763 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
FERMT1Fermitin family member 1. (444 aa)
SMURF2E3 ubiquitin-protein ligase. (736 aa)
ASPNAsporin. (372 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (464 aa)
ENSUAMP00000017634Uncharacterized protein. (139 aa)
ITGA3Integrin subunit alpha 3; Belongs to the integrin alpha chain family. (1051 aa)
HSPA5Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SKILSKI like proto-oncogene. (684 aa)
NRROSNegative regulator of reactive oxygen species. (692 aa)
AXIN1Axin 1. (867 aa)
ING2Inhibitor of growth protein. (280 aa)
SIRT1Sirtuin 1. (618 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
BAMBIBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (260 aa)
GIPC3GIPC PDZ domain containing family member 3. (294 aa)
ENSUAMP00000021865Uncharacterized protein. (846 aa)
THBS1Thrombospondin 1. (1170 aa)
GIPC1GIPC PDZ domain containing family member 1. (333 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
ENSUAMP00000023083Uncharacterized protein. (485 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (195 aa)
ENSUAMP00000023807PLAC domain-containing protein. (130 aa)
ENSUAMP00000023809ADAM_spacer1 domain-containing protein. (538 aa)
SKISKI proto-oncogene. (704 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
ENSUAMP00000024123Uncharacterized protein. (522 aa)
IL17FInterleukin 17F. (156 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (354 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (548 aa)
ENSUAMP00000025354HMG box domain-containing protein. (302 aa)
IL17RDInterleukin 17 receptor D. (709 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (237 aa)
ENSUAMP00000025766Uncharacterized protein. (229 aa)
GLG1Golgi glycoprotein 1. (1111 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD6Mothers against decapentaplegic homolog. (484 aa)
RASL11BRAS like family 11 member B. (249 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
ENSUAMP00000027731Kindlin_2_N domain-containing protein. (91 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (290 aa)
SLC2A10Solute carrier family 2 member 10; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (543 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (529 aa)
SNW1SNW domain containing 1. (511 aa)
ENGEndoglin. (650 aa)
ENSUAMP00000030338Uncharacterized protein. (115 aa)
LTBP1Latent transforming growth factor beta binding protein 1. (1554 aa)
CREBBPCREB binding protein. (2333 aa)
ZNF703Zinc finger protein 703. (592 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
NKX2-1NK2 homeobox 1. (370 aa)
EP300E1A binding protein p300. (2399 aa)
NPNTNephronectin. (462 aa)
C20orf27Chromosome 20 open reading frame 27. (174 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
BCL9LBCL9 like. (1497 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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