55 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000025261	GPS2_interact domain-containing protein. (204 aa)
	NCOR1	Nuclear receptor corepressor 1. (2267 aa)
	DDX20	DEAD-box helicase 20. (815 aa)
	SP3	Sp3 transcription factor. (780 aa)
	SIN3A	SIN3 transcription regulator family member A. (1275 aa)
	RELB	RELB proto-oncogene, NF-kB subunit. (575 aa)
	NCOR2	Nuclear receptor corepressor 2. (2465 aa)
	TFAP4	Transcription factor AP-4. (339 aa)
	PRDM10	PR/SET domain 10. (1105 aa)
	RCOR1	REST corepressor 1. (397 aa)
	ENSUAMP00000022260	Uncharacterized protein. (154 aa)
	ENSUAMP00000020133	Uncharacterized protein. (293 aa)
	ENSUAMP00000020121	PHD-type domain-containing protein. (129 aa)
	ENSUAMP00000020051	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (445 aa)
	CTNNBIP1	Catenin beta interacting protein 1. (70 aa)
	TBL1XR1	Transducin beta like 1 X-linked receptor 1. (520 aa)
	ENSUAMP00000017634	Uncharacterized protein. (139 aa)
	CORO2A	Coronin; Belongs to the WD repeat coronin family. (519 aa)
	HDGF	Heparin binding growth factor. (239 aa)
	ENSUAMP00000016646	Uncharacterized protein. (167 aa)
	LIN54	Lin-54 DREAM MuvB core complex component. (749 aa)
	GMNN	Geminin DNA replication inhibitor. (210 aa)
	DR1	Down-regulator of transcription 1. (176 aa)
	SP1	Sp1 transcription factor. (780 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (423 aa)
	FOXO3B	Forkhead box O3B. (244 aa)
	FOXO3	Forkhead box O3. (453 aa)
	SPEN	Spen family transcriptional repressor. (3674 aa)
	BIN1	Bridging integrator 1. (686 aa)
	GATA1	GATA binding protein 1. (413 aa)
	ARID4A	AT-rich interaction domain 4A. (1250 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
	ENSUAMP00000002924	Uncharacterized protein. (335 aa)
	HOXC9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (260 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	INSM2	INSM transcriptional repressor 2. (516 aa)
	ZNF469	Zinc finger protein 469. (3748 aa)
	ENSUAMP00000006607	Uncharacterized protein. (215 aa)
	ELANE	Elastase, neutrophil expressed; Belongs to the peptidase S1 family. (264 aa)
	AKIRIN2	Akirin 2. (203 aa)
	GFI1	Growth factor independent 1 transcriptional repressor. (448 aa)
	DRAP1	DR1 associated protein 1. (212 aa)
	LIN37	Lin-37 DREAM MuvB core complex component. (246 aa)
	MIER1	MIER1 transcriptional regulator. (461 aa)
	CTBP1	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (421 aa)
	ENSUAMP00000027842	Uncharacterized protein. (99 aa)
	ENSUAMP00000027843	Uncharacterized protein. (119 aa)
	CBX5	Chromobox 5. (191 aa)
	GLI3	GLI family zinc finger 3. (1413 aa)
	CCND1	Cyclin D1; Belongs to the cyclin family. (294 aa)
	C1D	C1D nuclear receptor corepressor. (133 aa)
	ENSUAMP00000034574	Uncharacterized protein. (525 aa)
	RBBP8	RB binding protein 8, endonuclease. (873 aa)
	HDAC3	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
	LIN9	Lin-9 DREAM MuvB core complex component. (506 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARID4A	ENSUAMP00000006607	ENSUAMP00000009601	ENSUAMP00000006607	AT-rich interaction domain 4A.	Uncharacterized protein.	0.467
ARID4A	ENSUAMP00000016646	ENSUAMP00000009601	ENSUAMP00000016646	AT-rich interaction domain 4A.	Uncharacterized protein.	0.467
ARID4A	ENSUAMP00000020121	ENSUAMP00000009601	ENSUAMP00000020121	AT-rich interaction domain 4A.	PHD-type domain-containing protein.	0.890
ARID4A	ENSUAMP00000020133	ENSUAMP00000009601	ENSUAMP00000020133	AT-rich interaction domain 4A.	Uncharacterized protein.	0.890
ARID4A	HDAC3	ENSUAMP00000009601	ENSUAMP00000037450	AT-rich interaction domain 4A.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.942
ARID4A	RCOR1	ENSUAMP00000009601	ENSUAMP00000024042	AT-rich interaction domain 4A.	REST corepressor 1.	0.770
ARID4A	SIN3A	ENSUAMP00000009601	ENSUAMP00000029463	AT-rich interaction domain 4A.	SIN3 transcription regulator family member A.	0.944
CCND1	GATA1	ENSUAMP00000032516	ENSUAMP00000011093	Cyclin D1; Belongs to the cyclin family.	GATA binding protein 1.	0.503
CCND1	HDAC3	ENSUAMP00000032516	ENSUAMP00000037450	Cyclin D1; Belongs to the cyclin family.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.726
CCND1	JUN	ENSUAMP00000032516	ENSUAMP00000009019	Cyclin D1; Belongs to the cyclin family.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.688
CCND1	RELB	ENSUAMP00000032516	ENSUAMP00000030557	Cyclin D1; Belongs to the cyclin family.	RELB proto-oncogene, NF-kB subunit.	0.459
CCND1	TP53	ENSUAMP00000032516	ENSUAMP00000000913	Cyclin D1; Belongs to the cyclin family.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.758
CTBP1	ENSUAMP00000020051	ENSUAMP00000027505	ENSUAMP00000020051	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.963
CTBP1	HDAC3	ENSUAMP00000027505	ENSUAMP00000037450	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.521
CTBP1	NCOR2	ENSUAMP00000027505	ENSUAMP00000030789	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Nuclear receptor corepressor 2.	0.448
CTBP1	RBBP8	ENSUAMP00000027505	ENSUAMP00000037012	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	RB binding protein 8, endonuclease.	0.924
CTBP1	RCOR1	ENSUAMP00000027505	ENSUAMP00000024042	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	REST corepressor 1.	0.631
CTBP1	SIN3A	ENSUAMP00000027505	ENSUAMP00000029463	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	SIN3 transcription regulator family member A.	0.400
DDX20	TP53	ENSUAMP00000024288	ENSUAMP00000000913	DEAD-box helicase 20.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.402
DR1	DRAP1	ENSUAMP00000015369	ENSUAMP00000026869	Down-regulator of transcription 1.	DR1 associated protein 1.	0.978