76 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000010403	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (66 aa)
	FBXL5	F-box and leucine rich repeat protein 5. (691 aa)
	SPSB2	SplA/ryanodine receptor domain and SOCS box containing 2. (263 aa)
	FBXO15	F-box protein 15. (436 aa)
	FBXL20	F-box and leucine rich repeat protein 20. (436 aa)
	ENSUAMP00000033960	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (58 aa)
	FBXO33	F-box protein 33. (556 aa)
	FBXW11	F-box and WD repeat domain containing 11. (543 aa)
	ENSUAMP00000031825	FBA domain-containing protein. (158 aa)
	FBXL19	F-box and leucine rich repeat protein 19. (703 aa)
	FBXO45	F-box protein 45. (303 aa)
	ENSUAMP00000031424	B30.2/SPRY domain-containing protein. (268 aa)
	ENSUAMP00000031423	Uncharacterized protein. (273 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	FBXW4	F-box and WD repeat domain containing 4. (595 aa)
	ARIH1	RBR-type E3 ubiquitin transferase. (448 aa)
	FBXO7	F-box protein 7. (523 aa)
	CUL2	Cullin 2; Belongs to the cullin family. (745 aa)
	ENSUAMP00000029036	Uncharacterized protein. (233 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (742 aa)
	FBXL2	F-box and leucine rich repeat protein 2. (422 aa)
	FBXO39	F-box protein 39. (443 aa)
	DAW1	Dynein assembly factor with WD repeats 1. (414 aa)
	FBXL4	F-box and leucine rich repeat protein 4. (453 aa)
	FBXO32	F-box protein 32. (353 aa)
	FBXO27	F-box protein 27. (279 aa)
	ENSUAMP00000027679	Uncharacterized protein. (51 aa)
	FBXL7	F-box and leucine rich repeat protein 7. (457 aa)
	FBXW7	F-box and WD repeat domain containing 7. (627 aa)
	FBXL3	F-box and leucine rich repeat protein 3. (428 aa)
	SKP2	S-phase kinase associated protein 2. (436 aa)
	FBXO6	F-box protein 6. (270 aa)
	FBXO44	F-box protein 44. (219 aa)
	FBXO2	F-box protein 2. (294 aa)
	ENSUAMP00000023965	F-box domain-containing protein. (94 aa)
	FBXL12	F-box and leucine rich repeat protein 12. (316 aa)
	FBXL14	F-box and leucine rich repeat protein 14. (420 aa)
	CKS2	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (74 aa)
	ENSUAMP00000020585	Uncharacterized protein. (252 aa)
	LRRC29	Leucine rich repeat containing 29. (166 aa)
	ENSUAMP00000019862	Uncharacterized protein. (350 aa)
	ENSUAMP00000019861	F-box domain-containing protein. (51 aa)
	FBXO31	F-box protein 31. (542 aa)
	CKS1B	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
	ENSUAMP00000017316	F-box domain-containing protein. (71 aa)
	SPSB3	SplA/ryanodine receptor domain and SOCS box containing 3. (379 aa)
	SPSB4	SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa)
	CCNF	Cyclin F; Belongs to the cyclin family. (776 aa)
	FBXL18	F-box and leucine rich repeat protein 18. (747 aa)
	FBXL16	F-box and leucine rich repeat protein 16. (524 aa)
	FBXO48	F-box protein 48. (155 aa)
	FBXO17	F-box protein 17. (277 aa)
	FBXO25	F-box protein 25. (366 aa)
	ENSUAMP00000012590	Uncharacterized protein. (206 aa)
	DMAC2	Distal membrane arm assembly complex 2. (289 aa)
	GSE1	Gse1 coiled-coil protein. (1086 aa)
	TRIM21	Tripartite motif containing 21. (469 aa)
	FBXO4	F-box protein 4. (303 aa)
	ENSUAMP00000001958	CS domain-containing protein. (97 aa)
	FBXW5	F-box and WD repeat domain containing 5. (725 aa)
	NCCRP1	Non-specific cytotoxic cell receptor protein 1 homolog (zebrafish). (262 aa)
	FBXO42	F-box protein 42. (401 aa)
	ENSUAMP00000004203	CS domain-containing protein. (109 aa)
	ENSUAMP00000004242	Uncharacterized protein. (138 aa)
	TRAF7	TNF receptor associated factor 7. (670 aa)
	USP47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1275 aa)
	FBXL6	F-box and leucine rich repeat protein 6. (533 aa)
	ENSUAMP00000007446	WD_REPEATS_REGION domain-containing protein. (380 aa)
	TMEM183A	Transmembrane protein 183A. (376 aa)
	CMIP	C-Maf inducing protein. (764 aa)
	CUL5	Cullin 5; Belongs to the cullin family. (662 aa)
	FBH1	F-box DNA helicase 1. (1046 aa)
	FBXO9	F-box protein 9. (435 aa)
	FBXL17	F-box and leucine rich repeat protein 17. (662 aa)
	FBXL15	F-box and leucine rich repeat protein 15. (300 aa)
	ENSUAMP00000010478	Uncharacterized protein. (91 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARIH1	CUL1	ENSUAMP00000030096	ENSUAMP00000028874	RBR-type E3 ubiquitin transferase.	Cullin 1; Belongs to the cullin family.	0.874
ARIH1	CUL2	ENSUAMP00000030096	ENSUAMP00000029166	RBR-type E3 ubiquitin transferase.	Cullin 2; Belongs to the cullin family.	0.524
ARIH1	ENSUAMP00000027679	ENSUAMP00000030096	ENSUAMP00000027679	RBR-type E3 ubiquitin transferase.	Uncharacterized protein.	0.874
ARIH1	SKP2	ENSUAMP00000030096	ENSUAMP00000025997	RBR-type E3 ubiquitin transferase.	S-phase kinase associated protein 2.	0.603
BTRC	CCNF	ENSUAMP00000031418	ENSUAMP00000016434	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cyclin F; Belongs to the cyclin family.	0.426
BTRC	CUL1	ENSUAMP00000031418	ENSUAMP00000028874	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Cullin 1; Belongs to the cullin family.	0.987
BTRC	ENSUAMP00000007446	ENSUAMP00000031418	ENSUAMP00000007446	Beta-transducin repeat containing E3 ubiquitin protein ligase.	WD_REPEATS_REGION domain-containing protein.	0.440
BTRC	ENSUAMP00000012590	ENSUAMP00000031418	ENSUAMP00000012590	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Uncharacterized protein.	0.929
BTRC	ENSUAMP00000027679	ENSUAMP00000031418	ENSUAMP00000027679	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Uncharacterized protein.	0.987
BTRC	FBXO2	ENSUAMP00000031418	ENSUAMP00000024523	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box protein 2.	0.959
BTRC	FBXO4	ENSUAMP00000031418	ENSUAMP00000000932	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box protein 4.	0.950
BTRC	FBXO44	ENSUAMP00000031418	ENSUAMP00000024524	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box protein 44.	0.425
BTRC	FBXO6	ENSUAMP00000031418	ENSUAMP00000024526	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box protein 6.	0.425
BTRC	FBXW11	ENSUAMP00000031418	ENSUAMP00000032203	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 11.	0.986
BTRC	FBXW7	ENSUAMP00000031418	ENSUAMP00000027479	Beta-transducin repeat containing E3 ubiquitin protein ligase.	F-box and WD repeat domain containing 7.	0.917
BTRC	SKP2	ENSUAMP00000031418	ENSUAMP00000025997	Beta-transducin repeat containing E3 ubiquitin protein ligase.	S-phase kinase associated protein 2.	0.969
BTRC	USP47	ENSUAMP00000031418	ENSUAMP00000007347	Beta-transducin repeat containing E3 ubiquitin protein ligase.	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family.	0.593
CCNF	BTRC	ENSUAMP00000016434	ENSUAMP00000031418	Cyclin F; Belongs to the cyclin family.	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.426
CCNF	CKS1B	ENSUAMP00000016434	ENSUAMP00000018064	Cyclin F; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.605
CCNF	CKS2	ENSUAMP00000016434	ENSUAMP00000020627	Cyclin F; Belongs to the cyclin family.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.605