(43 nodes) Nucleobase-containing compound kinase activity network (Ursus americanus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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gene fusions

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Your Input:
	AK3-3	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (235 aa)
	CLP1	Polyribonucleotide 5'-hydroxyl-kinase Clp1; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; thi [...] (425 aa)
	NT5C2	5'-nucleotidase, cytosolic II. (569 aa)
	CMPK1	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa)
	DCK	Deoxycytidine kinase. (260 aa)
	ENSUAMP00000035827	Uncharacterized protein. (175 aa)
	ENSUAMP00000034767	Uncharacterized protein; Belongs to the adenylate kinase family. (120 aa)
	AK7	Adenylate kinase 7. (718 aa)
	ENSUAMP00000032951	Uncharacterized protein. (506 aa)
	AK8	Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa)
	CMPK2	Cytidine/uridine monophosphate kinase 2. (361 aa)
	NME6	Nucleoside diphosphate kinase. (186 aa)
	AK1	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (245 aa)
	ENSUAMP00000028888	NDK domain-containing protein; Belongs to the NDK family. (89 aa)
	TK1	Thymidine kinase. (239 aa)
	ENSUAMP00000024998	NDK domain-containing protein. (144 aa)
	AK6	Adenylate kinase 6. (141 aa)
	ENSUAMP00000022965	Uncharacterized protein. (296 aa)
	GUK1	Guanylate kinase 1. (219 aa)
	DGUOK	Deoxyguanosine kinase. (291 aa)
	UCKL1	Uridine-cytidine kinase; Belongs to the uridine kinase family. (547 aa)
	ENSUAMP00000001002	Uncharacterized protein. (86 aa)
	AK3	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (235 aa)
	PNKP	Polynucleotide kinase 3'-phosphatase. (534 aa)
	NME1	Nucleoside diphosphate kinase. (152 aa)
	NME2	Nucleoside diphosphate kinase. (159 aa)
	NME9	NME/NM23 family member 9. (268 aa)
	TK2	Thymidine kinase 2. (216 aa)
	N4BP2	NEDD4 binding protein 2. (1833 aa)
	NOL9	Nucleolar protein 9. (675 aa)
	DTYMK	Deoxythymidylate kinase. (261 aa)
	UCK1	Uridine-cytidine kinase; Belongs to the uridine kinase family. (276 aa)
	AK3-2	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (283 aa)
	ENSUAMP00000011072	Guanylate kinase-like domain-containing protein. (1145 aa)
	NME4	Nucleoside diphosphate kinase. (187 aa)
	AK2	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa)
	ADK	Adenosine kinase. (311 aa)
	ENSUAMP00000017790	Uncharacterized protein. (126 aa)
	ENSUAMP00000017787	Uncharacterized protein. (167 aa)
	UCK2	Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
	ENSUAMP00000016857	Uncharacterized protein. (76 aa)
	NME3	Nucleoside diphosphate kinase. (169 aa)
	ENSUAMP00000015279	NDK domain-containing protein; Belongs to the NDK family. (181 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADK	AK1	ENSUAMP00000019200	ENSUAMP00000030019	Adenosine kinase.	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	0.965
ADK	AK2	ENSUAMP00000019200	ENSUAMP00000019257	Adenosine kinase.	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	0.979
ADK	AK3	ENSUAMP00000019200	ENSUAMP00000003284	Adenosine kinase.	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.886
ADK	AK3-2	ENSUAMP00000019200	ENSUAMP00000011016	Adenosine kinase.	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.901
ADK	AK3-3	ENSUAMP00000019200	ENSUAMP00000011148	Adenosine kinase.	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.886
ADK	AK6	ENSUAMP00000019200	ENSUAMP00000023827	Adenosine kinase.	Adenylate kinase 6.	0.951
ADK	AK7	ENSUAMP00000019200	ENSUAMP00000033789	Adenosine kinase.	Adenylate kinase 7.	0.958
ADK	AK8	ENSUAMP00000019200	ENSUAMP00000032472	Adenosine kinase.	Adenylate kinase 8; Belongs to the adenylate kinase family.	0.986
ADK	CMPK1	ENSUAMP00000019200	ENSUAMP00000037076	Adenosine kinase.	UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.	0.440
ADK	DCK	ENSUAMP00000019200	ENSUAMP00000036072	Adenosine kinase.	Deoxycytidine kinase.	0.968
ADK	ENSUAMP00000001002	ENSUAMP00000019200	ENSUAMP00000001002	Adenosine kinase.	Uncharacterized protein.	0.964
ADK	ENSUAMP00000016857	ENSUAMP00000019200	ENSUAMP00000016857	Adenosine kinase.	Uncharacterized protein.	0.953
ADK	ENSUAMP00000022965	ENSUAMP00000019200	ENSUAMP00000022965	Adenosine kinase.	Uncharacterized protein.	0.942
ADK	ENSUAMP00000032951	ENSUAMP00000019200	ENSUAMP00000032951	Adenosine kinase.	Uncharacterized protein.	0.449
ADK	ENSUAMP00000034767	ENSUAMP00000019200	ENSUAMP00000034767	Adenosine kinase.	Uncharacterized protein; Belongs to the adenylate kinase family.	0.901
ADK	NT5C2	ENSUAMP00000019200	ENSUAMP00000037180	Adenosine kinase.	5'-nucleotidase, cytosolic II.	0.950
ADK	TK2	ENSUAMP00000019200	ENSUAMP00000008054	Adenosine kinase.	Thymidine kinase 2.	0.564
AK1	ADK	ENSUAMP00000030019	ENSUAMP00000019200	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenosine kinase.	0.965
AK1	AK2	ENSUAMP00000030019	ENSUAMP00000019257	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.	0.958
AK1	AK3	ENSUAMP00000030019	ENSUAMP00000003284	Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.	GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.	0.453