STRINGSTRING
MED7 MED7 PHF19 PHF19 NOG NOG MED21 MED21 PROX1 PROX1 PELO PELO ENSUAMP00000002924 ENSUAMP00000002924 LIG4 LIG4 SFRP1 SFRP1 LSM1 LSM1 ENSUAMP00000005230 ENSUAMP00000005230 ENSUAMP00000005720 ENSUAMP00000005720 LIF LIF FGF10 FGF10 STAT3 STAT3 MED15-2 MED15-2 MED15 MED15 SS18 SS18 HES1 HES1 MMP24 MMP24 NODAL NODAL TRIM8 TRIM8 ENSUAMP00000011130 ENSUAMP00000011130 SETD6 SETD6 MED27 MED27 ENSUAMP00000012019 ENSUAMP00000012019 FOXO3 FOXO3 FOXO3B FOXO3B CUL4A CUL4A PAF1 PAF1 SALL4 SALL4 ENSUAMP00000012508 ENSUAMP00000012508 MED30 MED30 PCM1 PCM1 ENSUAMP00000014216 ENSUAMP00000014216 GNL3 GNL3 ENSUAMP00000000600 ENSUAMP00000000600 EIF4ENIF1 EIF4ENIF1 EIF4E EIF4E ENSUAMP00000017162 ENSUAMP00000017162 ENSUAMP00000017830 ENSUAMP00000017830 NIPBL NIPBL LEO1 LEO1 BCL9 BCL9 BRAF BRAF LRP5 LRP5 ENSUAMP00000025477 ENSUAMP00000025477 DIS3L2 DIS3L2 SOX9 SOX9 CTR9 CTR9 ENSUAMP00000027374 ENSUAMP00000027374 ZHX2 ZHX2 MED14 MED14 DLL1 DLL1 MTF2 MTF2 ENSUAMP00000029340 ENSUAMP00000029340 ZIC3 ZIC3 NANOS2 NANOS2 IGF2BP1 IGF2BP1 RAF1 RAF1 ENSUAMP00000030773 ENSUAMP00000030773 ENSUAMP00000030775 ENSUAMP00000030775 ENSUAMP00000030787 ENSUAMP00000030787 SMC1A SMC1A FAXC FAXC RTF1 RTF1 ASCL2 ASCL2 ZFP36L2 ZFP36L2 ENSUAMP00000032434 ENSUAMP00000032434 FGF4 FGF4 KLF10 KLF10 FZD7 FZD7 NOTCH1 NOTCH1 JAG1 JAG1 RIF1 RIF1 PRDM14 PRDM14 MED17 MED17 SMC3 SMC3 WNT9B WNT9B METTL14 METTL14 VPS72 VPS72 HESX1 HESX1 BMPR1A BMPR1A NR2E1 NR2E1 HOOK3 HOOK3 BCL9L BCL9L DDX6 DDX6 SRRT SRRT LDB1 LDB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MED7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (232 aa)
PHF19PHD finger protein 19. (580 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MED21Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (144 aa)
PROX1Prospero homeobox 1. (737 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
ENSUAMP00000002924Uncharacterized protein. (335 aa)
LIG4DNA ligase. (911 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
ENSUAMP00000005230Uncharacterized protein. (157 aa)
ENSUAMP00000005720Piwi domain-containing protein. (184 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
MED15-2Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (59 aa)
MED15Mediator of RNA polymerase II transcription subunit 15; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (657 aa)
SS18SS18 subunit of BAF chromatin remodeling complex. (367 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
MMP24Matrix metallopeptidase 24. (614 aa)
NODALNodal growth differentiation factor. (348 aa)
TRIM8Tripartite motif containing 8. (551 aa)
ENSUAMP00000011130Uncharacterized protein. (295 aa)
SETD6SET domain containing 6, protein lysine methyltransferase. (405 aa)
MED27Uncharacterized protein. (173 aa)
ENSUAMP00000012019Mediator of RNA polymerase II transcription subunit 21; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (104 aa)
FOXO3Forkhead box O3. (453 aa)
FOXO3BForkhead box O3B. (244 aa)
CUL4ACullin 4A; Belongs to the cullin family. (863 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (528 aa)
SALL4Spalt like transcription factor 4. (1053 aa)
ENSUAMP00000012508SMC_N domain-containing protein. (1106 aa)
MED30Mediator complex subunit 30. (178 aa)
PCM1Pericentriolar material 1. (2123 aa)
ENSUAMP00000014216Homeobox domain-containing protein. (315 aa)
GNL3G protein nucleolar 3. (550 aa)
ENSUAMP00000000600Uncharacterized protein. (130 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (898 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (180 aa)
ENSUAMP00000017162Uncharacterized protein. (137 aa)
ENSUAMP00000017830Uncharacterized protein. (157 aa)
NIPBLNipped-B protein. (1833 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (618 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
ENSUAMP00000025477Uncharacterized protein. (185 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (877 aa)
SOX9SRY-box transcription factor 9. (484 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
ENSUAMP00000027374Uncharacterized protein. (86 aa)
ZHX2Zinc fingers and homeoboxes 2. (840 aa)
MED14Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1450 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (757 aa)
MTF2Metal response element binding transcription factor 2. (597 aa)
ENSUAMP00000029340Uncharacterized protein. (254 aa)
ZIC3Uncharacterized protein. (466 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
RAF1Raf-1 proto-oncogene, serine/threonine kinase. (564 aa)
ENSUAMP00000030773Uncharacterized protein. (87 aa)
ENSUAMP00000030775Uncharacterized protein. (128 aa)
ENSUAMP00000030787Uncharacterized protein. (84 aa)
SMC1AStructural maintenance of chromosomes protein. (1239 aa)
FAXCFailed axon connections homolog, metaxin like GST domain containing. (409 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (424 aa)
ASCL2Achaete-scute family bHLH transcription factor 2. (194 aa)
ZFP36L2ZFP36 ring finger protein like 2. (496 aa)
ENSUAMP00000032434PAD_N domain-containing protein. (115 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
KLF10Kruppel like factor 10. (480 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
NOTCH1Notch receptor 1. (2547 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
RIF1Replication timing regulatory factor 1. (2251 aa)
PRDM14PR/SET domain 14. (566 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (651 aa)
SMC3Structural maintenance of chromosomes protein. (1215 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa)
VPS72Vacuolar protein sorting 72 homolog. (364 aa)
HESX1HESX homeobox 1. (185 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
HOOK3Hook microtubule tethering protein 3. (500 aa)
BCL9LBCL9 like. (1497 aa)
DDX6DEAD-box helicase 6; Belongs to the DEAD box helicase family. (483 aa)
SRRTSerrate, RNA effector molecule. (850 aa)
LDB1LIM domain binding 1. (411 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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