STRINGSTRING
HMOX1 HMOX1 ENSUAMP00000019443 ENSUAMP00000019443 PTGS2 PTGS2 NR1D1 NR1D1 CYP2R1 CYP2R1 ENSUAMP00000019124 ENSUAMP00000019124 CYP1B1 CYP1B1 ENSUAMP00000019082 ENSUAMP00000019082 CYP39A1 CYP39A1 SUOX SUOX ENSUAMP00000018414 ENSUAMP00000018414 CYB5R4 CYB5R4 ENSUAMP00000017402 ENSUAMP00000017402 CYP2F1 CYP2F1 ENSUAMP00000017348 ENSUAMP00000017348 CYGB CYGB FLVCR2 FLVCR2 CYP27B1 CYP27B1 TBXAS1 TBXAS1 ENSUAMP00000016311 ENSUAMP00000016311 ENSUAMP00000015114 ENSUAMP00000015114 ENSUAMP00000014774 ENSUAMP00000014774 NGB NGB BTBD6 BTBD6 ENSUAMP00000014088 ENSUAMP00000014088 IDO1 IDO1 ENSUAMP00000013982 ENSUAMP00000013982 ENSUAMP00000013975 ENSUAMP00000013975 CYP2J2 CYP2J2 ENSUAMP00000013738 ENSUAMP00000013738 DGCR8 DGCR8 ENSUAMP00000013261 ENSUAMP00000013261 CYP46A1 CYP46A1 ENSUAMP00000013046 ENSUAMP00000013046 RSAD1 RSAD1 CYP2B6 CYP2B6 ENSUAMP00000012599 ENSUAMP00000012599 ENSUAMP00000012528 ENSUAMP00000012528 B3GNT8 B3GNT8 PTGES2 PTGES2 ENSUAMP00000012176 ENSUAMP00000012176 CYP27C1 CYP27C1 ENSUAMP00000010632 ENSUAMP00000010632 ENSUAMP00000010543 ENSUAMP00000010543 ENSUAMP00000010295 ENSUAMP00000010295 ENSUAMP00000010225 ENSUAMP00000010225 CAT CAT ABCB6 ABCB6 ENSUAMP00000008430 ENSUAMP00000008430 NOS2 NOS2 CYB561D1 CYB561D1 CYP7B1 CYP7B1 ENSUAMP00000006803 ENSUAMP00000006803 LPO LPO ENSUAMP00000006303 ENSUAMP00000006303 EPX EPX HMOX2 HMOX2 ENSUAMP00000005042 ENSUAMP00000005042 HEBP2 HEBP2 STC2 STC2 CYP26C1 CYP26C1 CYP26A1 CYP26A1 ENSUAMP00000002638 ENSUAMP00000002638 ENSUAMP00000002533 ENSUAMP00000002533 HBM HBM ENSUAMP00000002526 ENSUAMP00000002526 ENSUAMP00000002525 ENSUAMP00000002525 HBQ1 HBQ1 ENSUAMP00000000729 ENSUAMP00000000729 GUCY1A1 GUCY1A1 ENSUAMP00000001009 ENSUAMP00000001009 ENSUAMP00000001083 ENSUAMP00000001083 ENSUAMP00000001093 ENSUAMP00000001093 ENSUAMP00000001103 ENSUAMP00000001103 ENSUAMP00000001114 ENSUAMP00000001114 ENSUAMP00000001131 ENSUAMP00000001131 ENSUAMP00000001136 ENSUAMP00000001136 ENSUAMP00000001144 ENSUAMP00000001144 ENSUAMP00000001157 ENSUAMP00000001157 ENSUAMP00000001168 ENSUAMP00000001168 CYP19A1 CYP19A1 ENSUAMP00000002024 ENSUAMP00000002024 ENSUAMP00000037554 ENSUAMP00000037554 CYB561D2 CYB561D2 ENSUAMP00000037337 ENSUAMP00000037337 CYP4F22 CYP4F22 ENSUAMP00000037275 ENSUAMP00000037275 ENSUAMP00000037273 ENSUAMP00000037273 CYP4F8 CYP4F8 ENSUAMP00000037267 ENSUAMP00000037267 CYC1 CYC1 CYP2U1 CYP2U1 SLC48A1 SLC48A1 TTI2 TTI2 CYP2W1 CYP2W1 CYP1A2 CYP1A2 CYP1A1 CYP1A1 CYP17A1 CYP17A1 ENSUAMP00000034639 ENSUAMP00000034639 ENSUAMP00000034638 ENSUAMP00000034638 PXDN PXDN ENSUAMP00000034486 ENSUAMP00000034486 TPO TPO NOS1 NOS1 ENSUAMP00000034394 ENSUAMP00000034394 CYP4X1 CYP4X1 CYP4B1 CYP4B1 CYP26B1 CYP26B1 CYP2E1 CYP2E1 ENSUAMP00000033863 ENSUAMP00000033863 CYP51A1 CYP51A1 ENSUAMP00000033428 ENSUAMP00000033428 ENSUAMP00000033421 ENSUAMP00000033421 NOS3 NOS3 DUOX2 DUOX2 DUOX1 DUOX1 CYBB CYBB XK XK ENSUAMP00000032152 ENSUAMP00000032152 CYP11A1 CYP11A1 EIF2AK1 EIF2AK1 CCDC160 CCDC160 ENSUAMP00000030726 ENSUAMP00000030726 HCCS HCCS CYB5D2 CYB5D2 SRC SRC ENSUAMP00000029679 ENSUAMP00000029679 CYP21A2 CYP21A2 CYCS CYCS FLVCR1 FLVCR1 GUCY1B1 GUCY1B1 TDO2 TDO2 ENSUAMP00000028021 ENSUAMP00000028021 ENSUAMP00000028019 ENSUAMP00000028019 ENSUAMP00000028006 ENSUAMP00000028006 CYP27A1 CYP27A1 ENSUAMP00000027762 ENSUAMP00000027762 PTGIS PTGIS ENSUAMP00000025782 ENSUAMP00000025782 ENSUAMP00000025403 ENSUAMP00000025403 ENSUAMP00000024931 ENSUAMP00000024931 FADS1 FADS1 CYP20A1 CYP20A1 ENSUAMP00000023721 ENSUAMP00000023721 PTGS1 PTGS1 ENSUAMP00000023045 ENSUAMP00000023045 CYP8B1 CYP8B1 MB MB CYP24A1 CYP24A1 HEBP1 HEBP1 HRG HRG ENSUAMP00000019446 ENSUAMP00000019446
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HMOX1Heme oxygenase 1. (288 aa)
ENSUAMP00000019443Uncharacterized protein. (281 aa)
PTGS2Prostaglandin-endoperoxide synthase 2. (604 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (600 aa)
CYP2R1Cytochrome P450 family 2 subfamily R member 1; Belongs to the cytochrome P450 family. (501 aa)
ENSUAMP00000019124Uncharacterized protein. (241 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
ENSUAMP00000019082Uncharacterized protein; Belongs to the cytochrome P450 family. (411 aa)
CYP39A1Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (469 aa)
SUOXSulfite oxidase; Belongs to the cytochrome b5 family. (488 aa)
ENSUAMP00000018414Uncharacterized protein; Belongs to the cytochrome P450 family. (404 aa)
CYB5R4Cytochrome b5 reductase 4. (390 aa)
ENSUAMP00000017402Uncharacterized protein. (494 aa)
CYP2F1Cytochrome P450 family 2 subfamily F member 1; Belongs to the cytochrome P450 family. (491 aa)
ENSUAMP00000017348Uncharacterized protein; Belongs to the cytochrome P450 family. (339 aa)
CYGBCytoglobin; Belongs to the globin family. (190 aa)
FLVCR2Feline leukemia virus subgroup C cellular receptor family member 2. (534 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
TBXAS1Thromboxane A synthase 1. (441 aa)
ENSUAMP00000016311Cytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (98 aa)
ENSUAMP00000015114Uncharacterized protein. (568 aa)
ENSUAMP00000014774Uncharacterized protein. (214 aa)
NGBNeuroglobin; Belongs to the globin family. (151 aa)
BTBD6BTB domain containing 6. (410 aa)
ENSUAMP00000014088Uncharacterized protein. (242 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (386 aa)
ENSUAMP00000013982Uncharacterized protein. (305 aa)
ENSUAMP00000013975Uncharacterized protein; Belongs to the cytochrome P450 family. (181 aa)
CYP2J2Cytochrome P450 family 2 subfamily J member 2; Belongs to the cytochrome P450 family. (469 aa)
ENSUAMP00000013738Uncharacterized protein. (86 aa)
DGCR8DGCR8 microprocessor complex subunit. (773 aa)
ENSUAMP00000013261Uncharacterized protein. (134 aa)
CYP46A1Cytochrome P450 family 46 subfamily A member 1; Belongs to the cytochrome P450 family. (506 aa)
ENSUAMP00000013046Uncharacterized protein. (120 aa)
RSAD1Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (442 aa)
CYP2B6Cytochrome P450 family 2 subfamily B member 6; Belongs to the cytochrome P450 family. (436 aa)
ENSUAMP00000012599Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (573 aa)
ENSUAMP00000012528Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
B3GNT8Hexosyltransferase. (397 aa)
PTGES2Prostaglandin E synthase 2; Belongs to the GST superfamily. (372 aa)
ENSUAMP00000012176Uncharacterized protein. (507 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa)
ENSUAMP00000010632Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
ENSUAMP00000010543RTTN_N domain-containing protein. (697 aa)
ENSUAMP00000010295DUF1794 domain-containing protein. (165 aa)
ENSUAMP00000010225Uncharacterized protein. (96 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (527 aa)
ABCB6ATP binding cassette subfamily B member 6 (Langereis blood group). (842 aa)
ENSUAMP00000008430Uncharacterized protein. (665 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1064 aa)
CYB561D1Cytochrome b561 family member D1. (229 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (485 aa)
ENSUAMP00000006803Uncharacterized protein; Belongs to the cytochrome P450 family. (262 aa)
LPOLactoperoxidase. (699 aa)
ENSUAMP00000006303Uncharacterized protein; Belongs to the cytochrome P450 family. (171 aa)
EPXEosinophil peroxidase. (715 aa)
HMOX2Heme oxygenase 2. (316 aa)
ENSUAMP00000005042Uncharacterized protein. (463 aa)
HEBP2Heme binding protein 2. (140 aa)
STC2Stanniocalcin 2. (302 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
CYP26A1Cytochrome P450 family 26 subfamily A member 1; Belongs to the cytochrome P450 family. (497 aa)
ENSUAMP00000002638Uncharacterized protein. (76 aa)
ENSUAMP00000002533GLOBIN domain-containing protein; Belongs to the globin family. (142 aa)
HBMHemoglobin subunit mu; Belongs to the globin family. (143 aa)
ENSUAMP00000002526GLOBIN domain-containing protein; Belongs to the globin family. (153 aa)
ENSUAMP00000002525GLOBIN domain-containing protein; Belongs to the globin family. (142 aa)
HBQ1Hemoglobin subunit theta 1; Belongs to the globin family. (161 aa)
ENSUAMP00000000729Uncharacterized protein; Belongs to the cytochrome P450 family. (180 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (681 aa)
ENSUAMP00000001009Uncharacterized protein. (183 aa)
ENSUAMP00000001083GLOBIN domain-containing protein; Belongs to the globin family. (147 aa)
ENSUAMP00000001093Uncharacterized protein. (163 aa)
ENSUAMP00000001103GLOBIN domain-containing protein; Belongs to the globin family. (147 aa)
ENSUAMP00000001114GLOBIN domain-containing protein; Belongs to the globin family. (147 aa)
ENSUAMP00000001131Uncharacterized protein. (154 aa)
ENSUAMP00000001136Uncharacterized protein. (80 aa)
ENSUAMP00000001144annotation not available (92 aa)
ENSUAMP00000001157Uncharacterized protein. (122 aa)
ENSUAMP00000001168GLOBIN domain-containing protein; Belongs to the globin family. (185 aa)
CYP19A1Cytochrome P450 family 19 subfamily A member 1; Belongs to the cytochrome P450 family. (465 aa)
ENSUAMP00000002024Uncharacterized protein. (375 aa)
ENSUAMP00000037554Ig-like domain-containing protein. (361 aa)
CYB561D2Cytochrome b561 family member D2. (222 aa)
ENSUAMP00000037337Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (143 aa)
CYP4F22Cytochrome P450 family 4 subfamily F member 22; Belongs to the cytochrome P450 family. (531 aa)
ENSUAMP00000037275Uncharacterized protein; Belongs to the cytochrome P450 family. (182 aa)
ENSUAMP00000037273Uncharacterized protein. (208 aa)
CYP4F8Uncharacterized protein; Belongs to the cytochrome P450 family. (524 aa)
ENSUAMP00000037267Uncharacterized protein. (83 aa)
CYC1Cytochrome c1. (325 aa)
CYP2U1Cytochrome P450 family 2 subfamily U member 1; Belongs to the cytochrome P450 family. (529 aa)
SLC48A1Solute carrier family 48 member 1. (136 aa)
TTI2TELO2 interacting protein 2. (477 aa)
CYP2W1Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family. (501 aa)
CYP1A2Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. (512 aa)
CYP1A1Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa)
CYP17A1Cytochrome P450 family 17 subfamily A member 1; Belongs to the cytochrome P450 family. (356 aa)
ENSUAMP00000034639Uncharacterized protein. (463 aa)
ENSUAMP00000034638Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
PXDNPeroxidasin. (905 aa)
ENSUAMP00000034486Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (96 aa)
TPOThyroid peroxidase. (1068 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1095 aa)
ENSUAMP00000034394Uncharacterized protein; Belongs to the cytochrome P450 family. (506 aa)
CYP4X1Cytochrome P450 family 4 subfamily X member 1; Belongs to the cytochrome P450 family. (506 aa)
CYP4B1Cytochrome P450 family 4 subfamily B member 1; Belongs to the cytochrome P450 family. (493 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
CYP2E1Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. (494 aa)
ENSUAMP00000033863Uncharacterized protein; Belongs to the cytochrome P450 family. (496 aa)
CYP51A1Cytochrome P450 family 51 subfamily A member 1; Belongs to the cytochrome P450 family. (503 aa)
ENSUAMP00000033428Uncharacterized protein. (169 aa)
ENSUAMP00000033421GLOBIN domain-containing protein; Belongs to the globin family. (135 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1202 aa)
DUOX2Dual oxidase 2. (1531 aa)
DUOX1Dual oxidase 1. (1539 aa)
CYBBCytochrome b-245 beta chain. (570 aa)
XKXK-related protein. (433 aa)
ENSUAMP00000032152Uncharacterized protein. (503 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (482 aa)
EIF2AK1Eukaryotic translation initiation factor 2 alpha kinase 1. (632 aa)
CCDC160Coiled-coil domain containing 160. (323 aa)
ENSUAMP00000030726Uncharacterized protein. (115 aa)
HCCSCytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c. (272 aa)
CYB5D2Cytochrome b5 domain containing 2; Belongs to the cytochrome b5 family. (264 aa)
SRCTyrosine-protein kinase. (557 aa)
ENSUAMP00000029679Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (673 aa)
CYP21A2Cytochrome P450 family 21 subfamily A member 2; Belongs to the cytochrome P450 family. (493 aa)
CYCSCytochrome c domain-containing protein; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (545 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (540 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (406 aa)
ENSUAMP00000028021Uncharacterized protein. (135 aa)
ENSUAMP00000028019Uncharacterized protein. (163 aa)
ENSUAMP00000028006Uncharacterized protein. (215 aa)
CYP27A1Cytochrome P450 family 27 subfamily A member 1; Belongs to the cytochrome P450 family. (441 aa)
ENSUAMP00000027762Uncharacterized protein. (188 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (499 aa)
ENSUAMP00000025782Uncharacterized protein. (257 aa)
ENSUAMP00000025403Cytochrome b5 heme-binding domain-containing protein. (107 aa)
ENSUAMP00000024931Uncharacterized protein. (162 aa)
FADS1Fatty acid desaturase 1. (466 aa)
CYP20A1Cytochrome P450 family 20 subfamily A member 1. (470 aa)
ENSUAMP00000023721Succinate dehydrogenase [ubiquinone] cytochrome b small subunit; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q); Belongs to the CybS family. (159 aa)
PTGS1Prostaglandin-endoperoxide synthase 1. (618 aa)
ENSUAMP00000023045Uncharacterized protein. (125 aa)
CYP8B1Cytochrome P450 family 8 subfamily B member 1; Belongs to the cytochrome P450 family. (501 aa)
MBMyoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (148 aa)
CYP24A1Cytochrome P450 family 24 subfamily A member 1; Belongs to the cytochrome P450 family. (516 aa)
HEBP1Heme binding protein 1. (189 aa)
HRGHistidine rich glycoprotein. (557 aa)
ENSUAMP00000019446Uncharacterized protein. (51 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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