75 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MKKS	McKusick-Kaufman syndrome. (570 aa)
	ALDH1A3	Aldehyde dehydrogenase 1 family member A3; Belongs to the aldehyde dehydrogenase family. (512 aa)
	NR2E1	Nuclear receptor subfamily 2 group E member 1. (385 aa)
	RAX	Retina and anterior neural fold homeobox. (335 aa)
	ENSUAMP00000035777	HMG box domain-containing protein. (191 aa)
	ATAT1	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...] (421 aa)
	UQCRQ	Ubiquinol-cytochrome c reductase complex III subunit VII. (82 aa)
	BBS4	Uncharacterized protein. (384 aa)
	FOXB1	Forkhead box B1. (325 aa)
	ENSUAMP00000032923	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
	FEZF2	FEZ family zinc finger 2. (443 aa)
	ENSUAMP00000032699	3Beta_HSD domain-containing protein; Belongs to the 3-beta-HSD family. (373 aa)
	NKX2-2	NK2 homeobox 2. (273 aa)
	TSC1	TSC complex subunit 1. (1168 aa)
	GLI3	GLI family zinc finger 3. (1413 aa)
	NKX2-1	NK2 homeobox 1. (370 aa)
	ENSUAMP00000031281	Uncharacterized protein. (466 aa)
	GSX1	GS homeobox 1. (263 aa)
	ENSUAMP00000030105	Uncharacterized protein. (165 aa)
	ZIC3	Uncharacterized protein. (466 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	ENSUAMP00000028700	Uncharacterized protein. (117 aa)
	NHLH2	Nescient helix-loop-helix 2. (135 aa)
	ENSUAMP00000027843	Uncharacterized protein. (119 aa)
	ENSUAMP00000027842	Uncharacterized protein. (99 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
	TMEM108	Transmembrane protein 108. (579 aa)
	TBR1	T-box brain transcription factor 1. (682 aa)
	ENSUAMP00000024890	Uncharacterized protein. (134 aa)
	OTP	Orthopedia homeobox. (325 aa)
	NF1	Neurofibromin 1. (2845 aa)
	ENSUAMP00000022370	Uncharacterized protein. (464 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (721 aa)
	EMX2	Empty spiracles homeobox 2. (252 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (851 aa)
	SRF	Serum response factor. (507 aa)
	NF2	Neurofibromin 2. (596 aa)
	ALK	Tyrosine-protein kinase receptor. (1234 aa)
	ENSUAMP00000018782	BBS1 domain-containing protein. (623 aa)
	PLXNA1	Plexin A1. (1852 aa)
	ENSUAMP00000018312	Uncharacterized protein. (98 aa)
	PTPRS	Protein tyrosine phosphatase receptor type S. (1910 aa)
	OGDH	Oxoglutarate dehydrogenase. (1083 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	ENSUAMP00000017162	Uncharacterized protein. (137 aa)
	BCAN	Brevican. (856 aa)
	CRK	CRK proto-oncogene, adaptor protein. (204 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
	UBA6	Ubiquitin like modifier activating enzyme 6; Belongs to the G-protein coupled receptor 1 family. (1413 aa)
	NHLH1	Nescient helix-loop-helix 1. (133 aa)
	ENSUAMP00000015361	CUB domain-containing protein. (131 aa)
	PLXNA3	Plexin A3. (1794 aa)
	NKX2-6	NK2 homeobox 6. (268 aa)
	XRCC1	X-ray repair cross complementing 1. (630 aa)
	RELN	Reelin. (3263 aa)
	ENSUAMP00000012266	CTNNB1_binding domain-containing protein. (162 aa)
	ENSUAMP00000012260	Uncharacterized protein. (58 aa)
	GSK3B	Glycogen synthase kinase 3 beta. (335 aa)
	ENSUAMP00000012039	Uncharacterized protein. (457 aa)
	DCX	Doublecortin. (371 aa)
	DLX2	Distal-less homeobox 2. (333 aa)
	DLX1	Distal-less homeobox 1. (255 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	LHX5	LIM homeobox 5. (402 aa)
	TSKU	Tsukushi, small leucine rich proteoglycan. (351 aa)
	MFSD2A	Major facilitator superfamily domain containing 2A. (527 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	ENSUAMP00000000755	FAM75 domain-containing protein. (606 aa)
	ENSUAMP00000000782	DUF4599 domain-containing protein. (242 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	CDK5R1	Cyclin-dependent kinase 5 activator. (307 aa)
	NEUROD6	Neurogenic differentiation factor. (337 aa)
	KIRREL3	Kirre like nephrin family adhesion molecule 3. (775 aa)
	SEMA3E	Semaphorin 3E; Belongs to the semaphorin family. (775 aa)
	BTG2	BTG anti-proliferation factor 2. (162 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALK	CRK	ENSUAMP00000019646	ENSUAMP00000016663	Tyrosine-protein kinase receptor.	CRK proto-oncogene, adaptor protein.	0.435
ALK	CRKL	ENSUAMP00000019646	ENSUAMP00000008326	Tyrosine-protein kinase receptor.	CRK like proto-oncogene, adaptor protein.	0.483
ALK	ENSUAMP00000032923	ENSUAMP00000019646	ENSUAMP00000032923	Tyrosine-protein kinase receptor.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.558
ALK	NF1	ENSUAMP00000019646	ENSUAMP00000024136	Tyrosine-protein kinase receptor.	Neurofibromin 1.	0.441
BBS2	BBS4	ENSUAMP00000021587	ENSUAMP00000033668	Bardet-Biedl syndrome 2 protein homolog.	Uncharacterized protein.	0.999
BBS2	ENSUAMP00000018782	ENSUAMP00000021587	ENSUAMP00000018782	Bardet-Biedl syndrome 2 protein homolog.	BBS1 domain-containing protein.	0.999
BBS2	ENSUAMP00000030105	ENSUAMP00000021587	ENSUAMP00000030105	Bardet-Biedl syndrome 2 protein homolog.	Uncharacterized protein.	0.940
BBS2	SMO	ENSUAMP00000021587	ENSUAMP00000027495	Bardet-Biedl syndrome 2 protein homolog.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.645
BBS4	BBS2	ENSUAMP00000033668	ENSUAMP00000021587	Uncharacterized protein.	Bardet-Biedl syndrome 2 protein homolog.	0.999
BBS4	ENSUAMP00000018782	ENSUAMP00000033668	ENSUAMP00000018782	Uncharacterized protein.	BBS1 domain-containing protein.	0.999
BBS4	ENSUAMP00000030105	ENSUAMP00000033668	ENSUAMP00000030105	Uncharacterized protein.	Uncharacterized protein.	0.942
BBS4	SMO	ENSUAMP00000033668	ENSUAMP00000027495	Uncharacterized protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.623
CDK5	CDK5R1	ENSUAMP00000029542	ENSUAMP00000002336	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Cyclin-dependent kinase 5 activator.	0.992
CDK5	ENSUAMP00000018312	ENSUAMP00000029542	ENSUAMP00000018312	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.992
CDK5	GSK3B	ENSUAMP00000029542	ENSUAMP00000012083	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Glycogen synthase kinase 3 beta.	0.530
CDK5	PLXNA1	ENSUAMP00000029542	ENSUAMP00000007965	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Plexin A1.	0.601
CDK5	PLXNA3	ENSUAMP00000029542	ENSUAMP00000014470	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	Plexin A3.	0.590
CDK5R1	CDK5	ENSUAMP00000002336	ENSUAMP00000029542	Cyclin-dependent kinase 5 activator.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.992
CDK5R1	GSK3B	ENSUAMP00000002336	ENSUAMP00000012083	Cyclin-dependent kinase 5 activator.	Glycogen synthase kinase 3 beta.	0.481
CDK5R1	PLXNA1	ENSUAMP00000002336	ENSUAMP00000007965	Cyclin-dependent kinase 5 activator.	Plexin A1.	0.473