STRINGSTRING
TGM2 TGM2 ENSUAMP00000000316 ENSUAMP00000000316 ENSUAMP00000000397 ENSUAMP00000000397 ENSUAMP00000000563 ENSUAMP00000000563 ENSUAMP00000000600 ENSUAMP00000000600 ENSUAMP00000001020 ENSUAMP00000001020 ENSUAMP00000001245 ENSUAMP00000001245 TBX2 TBX2 NOG NOG PROX1 PROX1 ENSUAMP00000003003 ENSUAMP00000003003 ENSUAMP00000003258 ENSUAMP00000003258 RARG RARG LRRC1 LRRC1 SFRP1 SFRP1 ENSUAMP00000004918 ENSUAMP00000004918 TWSG1 TWSG1 ESR1 ESR1 ENSUAMP00000006989 ENSUAMP00000006989 DAG1 DAG1 TP63 TP63 PTCH1 PTCH1 PLXNA1 PLXNA1 FGF10 FGF10 CAV1 CAV1 ENSUAMP00000009377 ENSUAMP00000009377 TGFB1 TGFB1 ENSUAMP00000013585 ENSUAMP00000013585 FGL1 FGL1 ENSUAMP00000014159 ENSUAMP00000014159 FOXA1 FOXA1 EDAR EDAR CUL3 CUL3 SERPINB5 SERPINB5 FGF7 FGF7 TNF TNF AREG AREG TGFB3 TGFB3 SOSTDC1 SOSTDC1 ENSUAMP00000017830 ENSUAMP00000017830 ENSUAMP00000018330 ENSUAMP00000018330 EPHA2 EPHA2 FEM1B FEM1B MSN MSN ESRP2 ESRP2 ENSUAMP00000020564 ENSUAMP00000020564 ENSUAMP00000020568 ENSUAMP00000020568 TGFB2 TGFB2 ENSUAMP00000021186 ENSUAMP00000021186 ENSUAMP00000023517 ENSUAMP00000023517 SEMA3C SEMA3C LRP5 LRP5 ELF3 ELF3 SOX9 SOX9 ENSUAMP00000027148 ENSUAMP00000027148 CEBPB CEBPB STAT6 STAT6 ENSUAMP00000027842 ENSUAMP00000027842 ENSUAMP00000027843 ENSUAMP00000027843 HOXB13 HOXB13 BSX BSX BMP4 BMP4 CSF1 CSF1 SRC SRC SLC9A3R1 SLC9A3R1 IL6 IL6 BTRC BTRC NKX2-3 NKX2-3 GLI3 GLI3 KDM5B KDM5B ENSUAMP00000033009 ENSUAMP00000033009 PML PML HOXD13 HOXD13 RXFP1 RXFP1 NOTCH2 NOTCH2 MED1 MED1 NOTCH1 NOTCH1 TNC TNC DDR1 DDR1 PLAG1 PLAG1 FRS2 FRS2 VDR VDR PHB2 PHB2 ENSUAMP00000036961 ENSUAMP00000036961
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGM2Transglutaminase 2. (687 aa)
ENSUAMP00000000316Homeobox domain-containing protein. (280 aa)
ENSUAMP00000000397Paired domain-containing protein. (216 aa)
ENSUAMP00000000563Uncharacterized protein. (1604 aa)
ENSUAMP00000000600Uncharacterized protein. (130 aa)
ENSUAMP00000001020Uncharacterized protein. (147 aa)
ENSUAMP00000001245CTF/NF-I domain-containing protein. (195 aa)
TBX2T-box transcription factor 2. (697 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PROX1Prospero homeobox 1. (737 aa)
ENSUAMP00000003003Plexin_cytopl domain-containing protein. (490 aa)
ENSUAMP00000003258Uncharacterized protein. (246 aa)
RARGRetinoic acid receptor gamma. (458 aa)
LRRC1Leucine rich repeat containing 1. (435 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
ENSUAMP00000004918Homeobox domain-containing protein. (230 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (202 aa)
ESR1Estrogen receptor 1. (490 aa)
ENSUAMP00000006989CTF/NF-I domain-containing protein. (213 aa)
DAG1Dystroglycan 1. (892 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
PTCH1Patched 1. (1453 aa)
PLXNA1Plexin A1. (1852 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
ENSUAMP00000009377Uncharacterized protein. (170 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ENSUAMP00000013585Uncharacterized protein. (588 aa)
FGL1Fibrinogen like 1. (312 aa)
ENSUAMP00000014159Uncharacterized protein. (78 aa)
FOXA1Forkhead box A1. (472 aa)
EDAREctodysplasin A receptor. (475 aa)
CUL3Cullin 3; Belongs to the cullin family. (766 aa)
SERPINB5Serpin family B member 5; Belongs to the serpin family. (375 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
AREGAmphiregulin. (257 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
ENSUAMP00000017830Uncharacterized protein. (157 aa)
ENSUAMP00000018330Uncharacterized protein. (346 aa)
EPHA2EPH receptor A2. (966 aa)
FEM1BFem-1 homolog B. (627 aa)
MSNMoesin. (577 aa)
ESRP2Epithelial splicing regulatory protein 2. (699 aa)
ENSUAMP00000020564HHH_8 domain-containing protein. (107 aa)
ENSUAMP00000020568DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (181 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
ENSUAMP00000021186Uncharacterized protein. (404 aa)
ENSUAMP00000023517Laminin N-terminal domain-containing protein. (378 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
ELF3E74 like ETS transcription factor 3. (369 aa)
SOX9SRY-box transcription factor 9. (484 aa)
ENSUAMP00000027148Uncharacterized protein. (221 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
ENSUAMP00000027842Uncharacterized protein. (99 aa)
ENSUAMP00000027843Uncharacterized protein. (119 aa)
HOXB13Homeobox B13. (285 aa)
BSXBrain specific homeobox. (232 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CSF1Colony stimulating factor 1. (518 aa)
SRCTyrosine-protein kinase. (557 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (366 aa)
IL6Interleukin 6. (212 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
NKX2-3NK2 homeobox 3. (318 aa)
GLI3GLI family zinc finger 3. (1413 aa)
KDM5BLysine demethylase 5B. (1039 aa)
ENSUAMP00000033009Uncharacterized protein. (1337 aa)
PMLPromyelocytic leukemia. (877 aa)
HOXD13Homeobox D13. (333 aa)
RXFP1Relaxin family peptide receptor 1. (724 aa)
NOTCH2Notch receptor 2. (2374 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
NOTCH1Notch receptor 1. (2547 aa)
TNCTenascin C. (2201 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (936 aa)
PLAG1PLAG1 zinc finger. (499 aa)
FRS2Fibroblast growth factor receptor substrate 2. (507 aa)
VDRVitamin D receptor. (427 aa)
PHB2Prohibitin. (297 aa)
ENSUAMP00000036961Uncharacterized protein. (86 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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