STRINGSTRING
PARVA PARVA CORO1B CORO1B ENSUAMP00000006688 ENSUAMP00000006688 PAK1 PAK1 ENSUAMP00000007085 ENSUAMP00000007085 ENSUAMP00000007313 ENSUAMP00000007313 DAG1 DAG1 RHOC RHOC RHOB RHOB ITGB1BP1 ITGB1BP1 PIK3CA PIK3CA SNX2 SNX2 ITGB1 ITGB1 PLCG1 PLCG1 AJUBA AJUBA PHACTR4 PHACTR4 PLCE1 PLCE1 ABI1 ABI1 FGD1 FGD1 ENSUAMP00000005976 ENSUAMP00000005976 ENSUAMP00000027784 ENSUAMP00000027784 STMN2 STMN2 ARHGEF7 ARHGEF7 WASF1 WASF1 ENSUAMP00000027207 ENSUAMP00000027207 TWF2 TWF2 CFL1 CFL1 ENSUAMP00000026437 ENSUAMP00000026437 CDC42 CDC42 SHTN1 SHTN1 VASP VASP KPTN KPTN ENSUAMP00000025990 ENSUAMP00000025990 SH3RF1 SH3RF1 CIB1 CIB1 ENSUAMP00000025109 ENSUAMP00000025109 GDPD2 GDPD2 PARVB PARVB CTTN CTTN ENSUAMP00000023991 ENSUAMP00000023991 ACTG2 ACTG2 ENSUAMP00000022642 ENSUAMP00000022642 ENSUAMP00000022639 ENSUAMP00000022639 ENSUAMP00000022636 ENSUAMP00000022636 BCAR1 BCAR1 ENSUAMP00000022217 ENSUAMP00000022217 CIB3 CIB3 P4HB P4HB ENSUAMP00000021477 ENSUAMP00000021477 DPYSL3 DPYSL3 SLC39A6 SLC39A6 ENSUAMP00000021345 ENSUAMP00000021345 IQGAP2 IQGAP2 ENSUAMP00000020296 ENSUAMP00000020296 CARMIL2 CARMIL2 FLOT2 FLOT2 DPP4 DPP4 NF2 NF2 ENSUAMP00000019671 ENSUAMP00000019671 ACTA1 ACTA1 ENSUAMP00000018897 ENSUAMP00000018897 ROCK1 ROCK1 EPHA2 EPHA2 APC2 APC2 ENSUAMP00000018309 ENSUAMP00000018309 ACTA2 ACTA2 HAX1 HAX1 ENSUAMP00000017587 ENSUAMP00000017587 ENSUAMP00000017103 ENSUAMP00000017103 FAT1 FAT1 ENSUAMP00000027942 ENSUAMP00000027942 ENSUAMP00000028141 ENSUAMP00000028141 MYLK MYLK ENSUAMP00000028558 ENSUAMP00000028558 CORO6 CORO6 CDK5 CDK5 PKD2 PKD2 MYH10 MYH10 ACTR3 ACTR3 KITLG KITLG IGF2BP1 IGF2BP1 ENSUAMP00000030336 ENSUAMP00000030336 ITGAV ITGAV RAC1 RAC1 FSCN1 FSCN1 RAC2 RAC2 CORO1C CORO1C CARMIL3 CARMIL3 KCNA1 KCNA1 ENSUAMP00000031604 ENSUAMP00000031604 ENSUAMP00000031858 ENSUAMP00000031858 PABPC1 PABPC1 RAC3 RAC3 TSC1 TSC1 AMOT AMOT CCDC88A CCDC88A ARPC5 ARPC5 ENSUAMP00000032832 ENSUAMP00000032832 UNC5C UNC5C ALS2 ALS2 TESK1 TESK1 ENSUAMP00000033520 ENSUAMP00000033520 VILL VILL DBNL DBNL PTK2B PTK2B ACTC1 ACTC1 SNX1 SNX1 KCNA2 KCNA2 GSN GSN ENSUAMP00000003176 ENSUAMP00000003176 ENSUAMP00000003003 ENSUAMP00000003003 PALLD PALLD WASF2 WASF2 VIL1 VIL1 ENSUAMP00000000101 ENSUAMP00000000101 PPP1R9B PPP1R9B LIMK1 LIMK1 ENSUAMP00000035446 ENSUAMP00000035446 ACTR3C ACTR3C ENSUAMP00000035555 ENSUAMP00000035555 ENSUAMP00000035608 ENSUAMP00000035608 ENSUAMP00000035622 ENSUAMP00000035622 ENSUAMP00000035838 ENSUAMP00000035838 PIP5K1A PIP5K1A ENSUAMP00000036288 ENSUAMP00000036288 INPPL1 INPPL1 CAPG CAPG VAMP7 VAMP7 ENSUAMP00000037356 ENSUAMP00000037356 APC APC ARHGEF6 ARHGEF6 FSCN3 FSCN3 ENSUAMP00000016192 ENSUAMP00000016192 AIF1 AIF1 ENSUAMP00000014181 ENSUAMP00000014181 CYFIP1 CYFIP1 ARPC3 ARPC3 ACTN1 ACTN1 ENSUAMP00000013195 ENSUAMP00000013195 CORO1A CORO1A ENSUAMP00000012405 ENSUAMP00000012405 CAPRIN1 CAPRIN1 STX3 STX3 ENSUAMP00000011933 ENSUAMP00000011933 ENSUAMP00000011922 ENSUAMP00000011922 ILK ILK PDLIM4 PDLIM4 ENSUAMP00000034022 ENSUAMP00000034022 ARHGAP31 ARHGAP31 CDC42BPB CDC42BPB ENSUAMP00000034416 ENSUAMP00000034416 FLOT1 FLOT1 ABITRAM ABITRAM DGKZ DGKZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PARVAParvin alpha. (286 aa)
CORO1BCoronin; Belongs to the WD repeat coronin family. (655 aa)
ENSUAMP00000006688Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (473 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
ENSUAMP00000007085Uncharacterized protein. (131 aa)
ENSUAMP00000007313Uncharacterized protein. (67 aa)
DAG1Dystroglycan 1. (892 aa)
RHOCRas homolog family member C. (254 aa)
RHOBRas homolog family member B. (172 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (199 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
SNX2Sorting nexin 2. (540 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (771 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1256 aa)
AJUBAAjuba LIM protein. (548 aa)
PHACTR4Phosphatase and actin regulator. (706 aa)
PLCE1Phosphoinositide phospholipase C. (1942 aa)
ABI1Abl interactor 1. (480 aa)
FGD1FYVE, RhoGEF and PH domain containing 1. (948 aa)
ENSUAMP00000005976Uncharacterized protein. (94 aa)
ENSUAMP00000027784Uncharacterized protein. (255 aa)
STMN2Stathmin; Belongs to the stathmin family. (168 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7. (782 aa)
WASF1WASP family member 1. (530 aa)
ENSUAMP00000027207Uncharacterized protein. (201 aa)
TWF2Twinfilin actin binding protein 2. (349 aa)
CFL1Cofilin 1; Belongs to the actin-binding proteins ADF family. (166 aa)
ENSUAMP00000026437Rho-GAP domain-containing protein. (638 aa)
CDC42Cell division cycle 42. (191 aa)
SHTN1Shootin 1. (647 aa)
VASPVasodilator stimulated phosphoprotein. (359 aa)
KPTNKaptin, actin binding protein. (318 aa)
ENSUAMP00000025990Uncharacterized protein. (200 aa)
SH3RF1SH3 domain containing ring finger 1. (767 aa)
CIB1Calcium and integrin binding 1. (191 aa)
ENSUAMP00000025109Uncharacterized protein. (168 aa)
GDPD2Glycerophosphodiester phosphodiesterase domain containing 2. (539 aa)
PARVBParvin beta. (371 aa)
CTTNCortactin. (502 aa)
ENSUAMP00000023991Uncharacterized protein. (84 aa)
ACTG2Actin gamma 2, smooth muscle. (389 aa)
ENSUAMP00000022642Uncharacterized protein. (552 aa)
ENSUAMP00000022639Uncharacterized protein. (580 aa)
ENSUAMP00000022636Uncharacterized protein. (644 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (867 aa)
ENSUAMP00000022217Uncharacterized protein. (78 aa)
CIB3Calcium and integrin binding family member 3. (185 aa)
P4HBProtein disulfide-isomerase. (510 aa)
ENSUAMP00000021477SH3 domain-containing protein. (267 aa)
DPYSL3Dihydropyrimidinase like 3. (534 aa)
SLC39A6Solute carrier family 39 member 6. (735 aa)
ENSUAMP00000021345Sorting_nexin domain-containing protein. (106 aa)
IQGAP2IQ motif containing GTPase activating protein 2. (1614 aa)
ENSUAMP00000020296Uncharacterized protein. (87 aa)
CARMIL2Capping protein regulator and myosin 1 linker 2. (1381 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (515 aa)
DPP4Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (765 aa)
NF2Neurofibromin 2. (596 aa)
ENSUAMP00000019671Tubulin beta chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
ACTA1Actin alpha 1, skeletal muscle. (377 aa)
ENSUAMP00000018897Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (206 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1365 aa)
EPHA2EPH receptor A2. (966 aa)
APC2APC regulator of WNT signaling pathway 2. (2266 aa)
ENSUAMP00000018309Uncharacterized protein. (85 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (280 aa)
ENSUAMP00000017587Uncharacterized protein. (1246 aa)
ENSUAMP00000017103Uncharacterized protein. (159 aa)
FAT1FAT atypical cadherin 1. (2954 aa)
ENSUAMP00000027942Link domain-containing protein. (477 aa)
ENSUAMP00000028141Uncharacterized protein. (225 aa)
MYLKMyosin light chain kinase. (1485 aa)
ENSUAMP00000028558Uncharacterized protein. (222 aa)
CORO6Coronin; Belongs to the WD repeat coronin family. (471 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (897 aa)
MYH10Myosin heavy chain 10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2194 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
ENSUAMP00000030336Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Belongs to the podocalyxin family. (504 aa)
ITGAVIntegrin subunit alpha V; Belongs to the integrin alpha chain family. (1047 aa)
RAC1Rac family small GTPase 1. (229 aa)
FSCN1Fascin. (431 aa)
RAC2Rac family small GTPase 2. (192 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
CARMIL3Capping protein regulator and myosin 1 linker 3. (1356 aa)
KCNA1Potassium voltage-gated channel subfamily A member 1; Belongs to the potassium channel family. (495 aa)
ENSUAMP00000031604Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1428 aa)
ENSUAMP00000031858Uncharacterized protein. (203 aa)
PABPC1Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (636 aa)
RAC3Rac family small GTPase 3. (202 aa)
TSC1TSC complex subunit 1. (1168 aa)
AMOTAngiomotin. (1058 aa)
CCDC88ACoiled-coil domain containing 88A. (1342 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
ENSUAMP00000032832Uncharacterized protein. (168 aa)
UNC5CUnc-5 netrin receptor C. (927 aa)
ALS2Alsin Rho guanine nucleotide exchange factor ALS2. (1644 aa)
TESK1Testis associated actin remodelling kinase 1. (628 aa)
ENSUAMP00000033520Death domain-containing protein. (248 aa)
VILLVillin like. (860 aa)
DBNLDrebrin like. (438 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (969 aa)
ACTC1Actin alpha cardiac muscle 1. (381 aa)
SNX1Sorting nexin 1. (304 aa)
KCNA2Potassium voltage-gated channel subfamily A member 2; Belongs to the potassium channel family. (499 aa)
GSNGelsolin. (742 aa)
ENSUAMP00000003176Uncharacterized protein. (335 aa)
ENSUAMP00000003003Plexin_cytopl domain-containing protein. (490 aa)
PALLDPalladin, cytoskeletal associated protein. (993 aa)
WASF2WASP family member 2. (461 aa)
VIL1Villin 1. (801 aa)
ENSUAMP00000000101HP domain-containing protein. (160 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (820 aa)
LIMK1LIM domain kinase 1. (580 aa)
ENSUAMP00000035446Uncharacterized protein. (259 aa)
ACTR3CUncharacterized protein; Belongs to the actin family. (323 aa)
ENSUAMP00000035555WH2 domain-containing protein. (207 aa)
ENSUAMP00000035608Uncharacterized protein. (85 aa)
ENSUAMP00000035622Uncharacterized protein. (662 aa)
ENSUAMP00000035838WH1 domain-containing protein. (92 aa)
PIP5K1APhosphatidylinositol-4-phosphate 5-kinase type 1 alpha. (549 aa)
ENSUAMP00000036288Ig-like domain-containing protein. (304 aa)
INPPL1Inositol polyphosphate phosphatase like 1. (1261 aa)
CAPGCapping actin protein, gelsolin like. (349 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
ENSUAMP00000037356Uncharacterized protein. (137 aa)
APCAPC regulator of WNT signaling pathway. (2832 aa)
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor 6. (782 aa)
FSCN3Fascin. (497 aa)
ENSUAMP00000016192Integrin beta; Belongs to the integrin beta chain family. (786 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
ENSUAMP00000014181Uncharacterized protein. (208 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1242 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (170 aa)
ACTN1Actinin alpha 1. (914 aa)
ENSUAMP00000013195Uncharacterized protein. (443 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
ENSUAMP00000012405Uncharacterized protein. (110 aa)
CAPRIN1Cell cycle associated protein 1. (709 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (289 aa)
ENSUAMP00000011933WH1 domain-containing protein. (160 aa)
ENSUAMP00000011922VASP_tetra domain-containing protein. (53 aa)
ILKIntegrin linked kinase. (503 aa)
PDLIM4PDZ and LIM domain 4. (229 aa)
ENSUAMP00000034022Uncharacterized protein. (97 aa)
ARHGAP31Rho GTPase activating protein 31. (1449 aa)
CDC42BPBCDC42 binding protein kinase beta; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1803 aa)
ENSUAMP00000034416Non-specific serine/threonine protein kinase. (686 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
ABITRAMActin binding transcription modulator. (181 aa)
DGKZDiacylglycerol kinase. (946 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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