(20 nodes) Macrophage differentiation network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	L3MBTL3	L3MBTL histone methyl-lysine binding protein 3. (780 aa)
	GAB3	GRB2 associated binding protein 3. (562 aa)
	CSF1	Colony stimulating factor 1. (518 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SOCS1	Suppressor of cytokine signaling 1. (214 aa)
	GBA	Glucosylceramidase. (540 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (161 aa)
	SIRT1	Sirtuin 1. (618 aa)
	VEGFA	Vascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (516 aa)
	NRROS	Negative regulator of reactive oxygen species. (692 aa)
	TSPAN2	Tetraspanin. (225 aa)
	ZBTB46	Zinc finger and BTB domain containing 46. (580 aa)
	EIF2AK1	Eukaryotic translation initiation factor 2 alpha kinase 1. (632 aa)
	CSF2	Colony stimulating factor 2. (155 aa)
	ENSUAMP00000008343	Uncharacterized protein. (163 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (395 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (481 aa)
	APP	Amyloid beta precursor protein. (735 aa)
	CEBPE	CCAAT/enhancer-binding protein. (281 aa)
	NKX2-3	NK2 homeobox 3. (318 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP10	CASP8	ENSUAMP00000007994	ENSUAMP00000007996	Caspase 10; Belongs to the peptidase C14A family.	Caspase 8; Belongs to the peptidase C14A family.	0.983
CASP8	CASP10	ENSUAMP00000007996	ENSUAMP00000007994	Caspase 8; Belongs to the peptidase C14A family.	Caspase 10; Belongs to the peptidase C14A family.	0.983
CSF1	CSF2	ENSUAMP00000028977	ENSUAMP00000008358	Colony stimulating factor 1.	Colony stimulating factor 2.	0.711
CSF1	ENSUAMP00000008343	ENSUAMP00000028977	ENSUAMP00000008343	Colony stimulating factor 1.	Uncharacterized protein.	0.711
CSF1	IL15	ENSUAMP00000028977	ENSUAMP00000025693	Colony stimulating factor 1.	Interleukin; Belongs to the IL-15/IL-21 family.	0.555
CSF2	CSF1	ENSUAMP00000008358	ENSUAMP00000028977	Colony stimulating factor 2.	Colony stimulating factor 1.	0.711
CSF2	IL15	ENSUAMP00000008358	ENSUAMP00000025693	Colony stimulating factor 2.	Interleukin; Belongs to the IL-15/IL-21 family.	0.617
ENSUAMP00000008343	CSF1	ENSUAMP00000008343	ENSUAMP00000028977	Uncharacterized protein.	Colony stimulating factor 1.	0.711
ENSUAMP00000008343	IL15	ENSUAMP00000008343	ENSUAMP00000025693	Uncharacterized protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.617
IL15	CSF1	ENSUAMP00000025693	ENSUAMP00000028977	Interleukin; Belongs to the IL-15/IL-21 family.	Colony stimulating factor 1.	0.555
IL15	CSF2	ENSUAMP00000025693	ENSUAMP00000008358	Interleukin; Belongs to the IL-15/IL-21 family.	Colony stimulating factor 2.	0.617
IL15	ENSUAMP00000008343	ENSUAMP00000025693	ENSUAMP00000008343	Interleukin; Belongs to the IL-15/IL-21 family.	Uncharacterized protein.	0.617