STRINGSTRING
ENSUAMP00000028653 ENSUAMP00000028653 SLIT3 SLIT3 SLIT2 SLIT2 NME6 NME6 SEMA4C SEMA4C MYL2 MYL2 SH3BP4 SH3BP4 PHB PHB SESN2 SESN2 CCAR2 CCAR2 SMARCA2 SMARCA2 PML PML CGRRF1 CGRRF1 GDF9 GDF9 SEMA3D SEMA3D DCSTAMP DCSTAMP MYL10 MYL10 GJA1 GJA1 PPP1R9B PPP1R9B WNT3 WNT3 SEMA6C SEMA6C SOX17 SOX17 BMPR2 BMPR2 HYAL2 HYAL2 HYAL1 HYAL1 IFRD2 IFRD2 SEMA3B SEMA3B SEMA3F SEMA3F SERTAD3 SERTAD3 SERTAD1 SERTAD1 NDUFS3 NDUFS3 GDF2 GDF2 ENSUAMP00000000254 ENSUAMP00000000254 MSX1 MSX1 NDUFA13 NDUFA13 YJEFN3 YJEFN3 TP53 TP53 ENSUAMP00000001879 ENSUAMP00000001879 ENSUAMP00000002165 ENSUAMP00000002165 WNT11 WNT11 FHL1 FHL1 SPART SPART ENSUAMP00000004152 ENSUAMP00000004152 SFRP1 SFRP1 PTPRJ PTPRJ ENSUAMP00000006064 ENSUAMP00000006064 ENSUAMP00000006350 ENSUAMP00000006350 SEMA3E SEMA3E ENSUAMP00000006566 ENSUAMP00000006566 SEMA6D SEMA6D ENSUAMP00000006800 ENSUAMP00000006800 GNG4 GNG4 INHBA INHBA SEMA3G SEMA3G CDKN1B CDKN1B ST7L ST7L ENSUAMP00000009188 ENSUAMP00000009188 SERPINE2 SERPINE2 ST7 ST7 RBBP7 RBBP7 ENSUAMP00000010431 ENSUAMP00000010431 RYK RYK SEMA6A SEMA6A DNAJB2 DNAJB2 ENSUAMP00000011272 ENSUAMP00000011272 ENSUAMP00000011275 ENSUAMP00000011275 ENPP1 ENPP1 CCN3 CCN3 MINAR1 MINAR1 CYP27C1 CYP27C1 WNT3A WNT3A TGFB1 TGFB1 EAF2 EAF2 RERG RERG SPHK2 SPHK2 RTN4R RTN4R BCL6 BCL6 PLXNA3 PLXNA3 OSTN OSTN MUL1 MUL1 DCBLD2 DCBLD2 RB1 RB1 ENSUAMP00000015215 ENSUAMP00000015215 SEMA7A SEMA7A BMP10 BMP10 DIP2B DIP2B ENSUAMP00000016276 ENSUAMP00000016276 CYP27B1 CYP27B1 DDX3X DDX3X SEMA4A SEMA4A ACVRL1 ACVRL1 ACVR1B ACVR1B CRLF3 CRLF3 ADAM15 ADAM15 PTPRS PTPRS SMAD4 SMAD4 SMARCA4 SMARCA4 CIRBP CIRBP TSPYL2 TSPYL2 HRG HRG RACK1 RACK1 SEMA4D SEMA4D TGFB2 TGFB2 CDKN2AIP CDKN2AIP ENSUAMP00000021252 ENSUAMP00000021252 NAIF1 NAIF1 SIRT1 SIRT1 ENSUAMP00000021600 ENSUAMP00000021600 HNF4A HNF4A ULK1 ULK1 ENSUAMP00000022548 ENSUAMP00000022548 DCUN1D3 DCUN1D3 IP6K2 IP6K2 WT1 WT1 ENSUAMP00000023172 ENSUAMP00000023172 OSGIN2 OSGIN2 SEMA4G SEMA4G ENSUAMP00000023517 ENSUAMP00000023517 CDKN2D CDKN2D SEMA4F SEMA4F SEMA6B SEMA6B FRZB FRZB RTN4 RTN4 SEMA4B SEMA4B SEMA3C SEMA3C CDKN2C CDKN2C SMAD3 SMAD3 CCDC85B CCDC85B ENSUAMP00000026980 ENSUAMP00000026980 CDKN1A CDKN1A PSRC1 PSRC1 CDK5 CDK5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000028653Uncharacterized protein. (748 aa)
SLIT3Slit guidance ligand 3. (1441 aa)
SLIT2Slit guidance ligand 2. (1450 aa)
NME6Nucleoside diphosphate kinase. (186 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
MYL2Myosin light chain 2. (192 aa)
SH3BP4SH3 domain binding protein 4. (895 aa)
PHBProhibitin. (272 aa)
SESN2Sestrin 2. (463 aa)
CCAR2Cell cycle and apoptosis regulator 2. (918 aa)
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2. (1421 aa)
PMLPromyelocytic leukemia. (877 aa)
CGRRF1Cell growth regulator with ring finger domain 1. (332 aa)
GDF9Growth differentiation factor 9. (453 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
MYL10Myosin light chain 10. (215 aa)
GJA1Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli a [...] (382 aa)
PPP1R9BProtein phosphatase 1 regulatory subunit 9B. (820 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (949 aa)
SOX17SRY-box transcription factor 17. (406 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
HYAL2Hyaluronidase. (472 aa)
HYAL1Hyaluronidase. (435 aa)
IFRD2Interferon related developmental regulator 2. (441 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (773 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (662 aa)
SERTAD3SERTA domain containing 3. (198 aa)
SERTAD1SERTA domain containing 1. (236 aa)
NDUFS3NADH:ubiquinone oxidoreductase core subunit S3; Belongs to the complex I 30 kDa subunit family. (337 aa)
GDF2Growth differentiation factor 2. (429 aa)
ENSUAMP00000000254Uncharacterized protein. (305 aa)
MSX1Msh homeobox 1. (303 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
YJEFN3YjeF N-terminal domain-containing protein. (250 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ENSUAMP00000001879Protein kinase domain-containing protein. (335 aa)
ENSUAMP00000002165Sema domain-containing protein; Belongs to the semaphorin family. (424 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FHL1Four and a half LIM domains 1. (295 aa)
SPARTSpartin. (672 aa)
ENSUAMP00000004152Uncharacterized protein. (265 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
PTPRJProtein tyrosine phosphatase receptor type J. (1211 aa)
ENSUAMP00000006064Uncharacterized protein. (80 aa)
ENSUAMP00000006350Uncharacterized protein. (85 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
ENSUAMP00000006566UDENN FLCN/SMCR8-type domain-containing protein. (579 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1086 aa)
ENSUAMP00000006800Uncharacterized protein. (97 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
INHBAInhibin subunit beta A. (424 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (712 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (200 aa)
ST7LSuppression of tumorigenicity 7 like. (556 aa)
ENSUAMP00000009188Sema domain-containing protein; Belongs to the semaphorin family. (541 aa)
SERPINE2Serpin family E member 2; Belongs to the serpin family. (232 aa)
ST7Suppression of tumorigenicity 7. (554 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (427 aa)
ENSUAMP00000010431Uncharacterized protein. (415 aa)
RYKReceptor like tyrosine kinase. (599 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (619 aa)
DNAJB2DnaJ heat shock protein family (Hsp40) member B2. (333 aa)
ENSUAMP00000011272FBPase domain-containing protein; Belongs to the FBPase class 1 family. (293 aa)
ENSUAMP00000011275FBPase domain-containing protein. (57 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase 1. (863 aa)
CCN3Cellular communication network factor 3. (353 aa)
MINAR1Membrane integral NOTCH2 associated receptor 1. (917 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
EAF2ELL associated factor 2. (249 aa)
RERGRAS like estrogen regulated growth inhibitor. (199 aa)
SPHK2Sphingosine kinase 2. (662 aa)
RTN4RReticulon 4 receptor. (472 aa)
BCL6BCL6 transcription repressor. (706 aa)
PLXNA3Plexin A3. (1794 aa)
OSTNOsteocrin. (132 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (252 aa)
DCBLD2Discoidin, CUB and LCCL domain containing 2. (782 aa)
RB1RB transcriptional corepressor 1. (870 aa)
ENSUAMP00000015215Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (467 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (663 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
DIP2BDisco interacting protein 2 homolog B. (1554 aa)
ENSUAMP00000016276Uncharacterized protein; Belongs to the DEAD box helicase family. (661 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (675 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (755 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
CRLF3Cytokine receptor like factor 3. (430 aa)
ADAM15ADAM metallopeptidase domain 15. (832 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1910 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4. (1614 aa)
CIRBPCold inducible RNA binding protein. (314 aa)
TSPYL2TSPY like 2; Belongs to the nucleosome assembly protein (NAP) family. (706 aa)
HRGHistidine rich glycoprotein. (557 aa)
RACK1Receptor for activated C kinase 1. (374 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (976 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
CDKN2AIPCDKN2A interacting protein. (571 aa)
ENSUAMP00000021252Uncharacterized protein. (409 aa)
NAIF1Nuclear apoptosis inducing factor 1. (327 aa)
SIRT1Sirtuin 1. (618 aa)
ENSUAMP00000021600Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (203 aa)
HNF4AHepatocyte nuclear factor 4 alpha. (474 aa)
ULK1Unc-51 like autophagy activating kinase 1. (974 aa)
ENSUAMP00000022548Uncharacterized protein. (342 aa)
DCUN1D3DCN1-like protein. (304 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (425 aa)
WT1WT1 transcription factor. (522 aa)
ENSUAMP00000023172Uncharacterized protein. (275 aa)
OSGIN2Oxidative stress induced growth inhibitor family member 2. (473 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (822 aa)
ENSUAMP00000023517Laminin N-terminal domain-containing protein. (378 aa)
CDKN2DCyclin dependent kinase inhibitor 2D. (166 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (762 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (764 aa)
FRZBFrizzled related protein. (298 aa)
RTN4Reticulon. (951 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (831 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (168 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
CCDC85BCoiled-coil domain containing 85B. (202 aa)
ENSUAMP00000026980Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (299 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
PSRC1Proline and serine rich coiled-coil 1. (357 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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