STRINGSTRING
ACTN2 ACTN2 ZMIZ1 ZMIZ1 PPRC1 PPRC1 MED17 MED17 NCOA2 NCOA2 MED1 MED1 ENSUAMP00000033090 ENSUAMP00000033090 ENSUAMP00000033087 ENSUAMP00000033087 CCAR2 CCAR2 ATXN7L3 ATXN7L3 ENSUAMP00000029322 ENSUAMP00000029322 ENSUAMP00000028373 ENSUAMP00000028373 ELK1 ELK1 ACTN4 ACTN4 CNOT9 CNOT9 PPARGC1A PPARGC1A PKN1 PKN1 NCOA3 NCOA3 TACC1 TACC1 ENSUAMP00000002355 ENSUAMP00000002355 BRD8 BRD8 ENY2 ENY2 SFR1 SFR1 ENSUAMP00000004053 ENSUAMP00000004053 CNOT6 CNOT6 ENY2-2 ENY2-2 SRA1 SRA1 ENSUAMP00000006869 ENSUAMP00000006869 PRKCB PRKCB NCOA1 NCOA1 PSMC3IP PSMC3IP SS18 SS18 DCAF6 DCAF6 BUD31 BUD31 NCOA7 NCOA7 CALCOCO1 CALCOCO1 SLC30A9 SLC30A9 ACTN1 ACTN1 TMF1 TMF1 NCOA6 NCOA6 TADA3 TADA3 ZMIZ2 ZMIZ2 WDR77 WDR77 RBM14 RBM14 ETS1 ETS1 HMGA1 HMGA1 CCAR1 CCAR1 ENSUAMP00000022273 ENSUAMP00000022273
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACTN2Actinin alpha 2. (894 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1044 aa)
PPRC1PPARG related coactivator 1. (1579 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (651 aa)
NCOA2Nuclear receptor coactivator 2. (945 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
ENSUAMP00000033090Uncharacterized protein. (2587 aa)
ENSUAMP00000033087AAA_12 domain-containing protein. (213 aa)
CCAR2Cell cycle and apoptosis regulator 2. (918 aa)
ATXN7L3Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] (408 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
ENSUAMP00000028373Uncharacterized protein. (68 aa)
ELK1ETS transcription factor ELK1. (435 aa)
ACTN4Actinin alpha 4. (970 aa)
CNOT9CCR4-NOT transcription complex subunit 9. (300 aa)
PPARGC1APPARG coactivator 1 alpha. (761 aa)
PKN1Protein kinase domain-containing protein. (739 aa)
NCOA3Nuclear receptor coactivator. (1431 aa)
TACC1Transforming acidic coiled-coil containing protein 1. (769 aa)
ENSUAMP00000002355Bromo domain-containing protein. (278 aa)
BRD8Bromo domain-containing protein. (936 aa)
ENY2Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (163 aa)
SFR1SWI5 dependent homologous recombination repair protein 1. (198 aa)
ENSUAMP00000004053Uncharacterized protein. (104 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (498 aa)
ENY2-2Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (101 aa)
SRA1Steroid receptor RNA activator 1. (244 aa)
ENSUAMP00000006869Uncharacterized protein. (392 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
NCOA1Nuclear receptor coactivator. (1441 aa)
PSMC3IPPSMC3 interacting protein. (217 aa)
SS18SS18 subunit of BAF chromatin remodeling complex. (367 aa)
DCAF6DDB1 and CUL4 associated factor 6. (840 aa)
BUD31BUD31 homolog. (144 aa)
NCOA7Nuclear receptor coactivator 7. (932 aa)
CALCOCO1Calcium binding and coiled-coil domain 1. (691 aa)
SLC30A9Solute carrier family 30 member 9. (570 aa)
ACTN1Actinin alpha 1. (914 aa)
TMF1TATA element modulatory factor 1. (1089 aa)
NCOA6Nuclear receptor coactivator 6. (2033 aa)
TADA3Transcriptional adaptor 3. (432 aa)
ZMIZ2Zinc finger MIZ-type containing 2. (922 aa)
WDR77WD repeat domain 77. (342 aa)
RBM14RNA binding motif protein 14. (618 aa)
ETS1ETS proto-oncogene 1, transcription factor. (531 aa)
HMGA1High mobility group AT-hook 1. (107 aa)
CCAR1Cell division cycle and apoptosis regulator 1. (1185 aa)
ENSUAMP00000022273AGC-kinase C-terminal domain-containing protein. (60 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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